5ZXH

The structure of MT189-tubulin complex

?

Functional Information from GO Data

ChainGOidnamespacecontents
E0005737cellular_componentcytoplasm
E0005794cellular_componentGolgi apparatus
E0030426cellular_componentgrowth cone
E0043005cellular_componentneuron projection
E0015631molecular_functiontubulin binding
E0007019biological_processmicrotubule depolymerization
E0031175biological_processneuron projection development
E0051493biological_processregulation of cytoskeleton organization
E0031110biological_processregulation of microtubule polymerization or depolymerization
A0005737cellular_componentcytoplasm
A0005874cellular_componentmicrotubule
A0005525molecular_functionGTP binding
A0003924molecular_functionGTPase activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0000226biological_processmicrotubule cytoskeleton organization
A0007017biological_processmicrotubule-based process
A0000278biological_processmitotic cell cycle
C0005737cellular_componentcytoplasm
C0005874cellular_componentmicrotubule
C0005525molecular_functionGTP binding
C0003924molecular_functionGTPase activity
C0005200molecular_functionstructural constituent of cytoskeleton
C0000226biological_processmicrotubule cytoskeleton organization
C0007017biological_processmicrotubule-based process
C0000278biological_processmitotic cell cycle
B0005737cellular_componentcytoplasm
B0005874cellular_componentmicrotubule
B0015630cellular_componentmicrotubule cytoskeleton
B0005525molecular_functionGTP binding
B0003924molecular_functionGTPase activity
B0046982molecular_functionprotein heterodimerization activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0000226biological_processmicrotubule cytoskeleton organization
B0007017biological_processmicrotubule-based process
B0000278biological_processmitotic cell cycle
B0001764biological_processneuron migration
B1902669biological_processpositive regulation of axon guidance
D0005737cellular_componentcytoplasm
D0005874cellular_componentmicrotubule
D0015630cellular_componentmicrotubule cytoskeleton
D0005525molecular_functionGTP binding
D0003924molecular_functionGTPase activity
D0046982molecular_functionprotein heterodimerization activity
D0005200molecular_functionstructural constituent of cytoskeleton
D0000226biological_processmicrotubule cytoskeleton organization
D0007017biological_processmicrotubule-based process
D0000278biological_processmitotic cell cycle
D0001764biological_processneuron migration
D1902669biological_processpositive regulation of axon guidance
F0005623cellular_componentcell
F0000166molecular_functionnucleotide binding
F0004835molecular_functiontubulin-tyrosine ligase activity
F0018166biological_processC-terminal protein-tyrosinylation
F0000226biological_processmicrotubule cytoskeleton organization
F0045931biological_processpositive regulation of mitotic cell cycle
F0030516biological_processregulation of axon extension
F0090235biological_processregulation of metaphase plate congression
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC123binding site for residue GTP A 501
ChainResidue
AGLY10
AGLN11
AALA12
AGLN15
AASP98
AALA99
AASN101
ASER140
AGLY143
AGLY144
ATHR145
AGLY146
AVAL177
AGLU183
AASN206
ATYR224
AASN228
AILE231
AMG502
AHOH603
AHOH604
AHOH606
BLYS252

AC25binding site for residue MG A 502
ChainResidue
AGTP501
AHOH602
AHOH604
AHOH606
BHOH601

AC34binding site for residue CA A 503
ChainResidue
AASP39
ATHR41
AGLY44
AGLU55

AC417binding site for residue GDP B 501
ChainResidue
BGLY10
BGLN11
BCYS12
BGLN15
BSER138
BGLY141
BGLY142
BTHR143
BGLY144
BPRO171
BVAL175
BASP177
BGLU181
BASN204
BTYR222
BASN226
BMG502

AC53binding site for residue MG B 502
ChainResidue
BGLN11
BASP177
BGDP501

AC67binding site for residue MES B 503
ChainResidue
BARG156
BPRO160
BASP161
BARG162
BASN195
BASP197
BARG251

AC71binding site for residue CA B 504
ChainResidue
BGLU111

AC87binding site for residue MES B 505
ChainResidue
BPHE294
BASP295
BSER296
BPRO305
BARG306
BTYR310
BASN337

AC916binding site for residue 9LX B 506
ChainResidue
ATHR179
AVAL181
BVAL236
BCYS239
BLEU246
BASP249
BLEU253
BASN256
BMET257
BVAL313
BALA314
BVAL316
BASN348
BLYS350
BTHR351
BALA352

AD123binding site for residue GTP C 501
ChainResidue
CGLN11
CALA12
CGLN15
CASP98
CALA99
CALA100
CASN101
CSER140
CGLY143
CGLY144
CTHR145
CGLY146
CVAL177
CGLU183
CASN206
CTYR224
CASN228
CILE231
CMG502
CHOH601
CHOH602
CHOH604
DLYS252

AD25binding site for residue MG C 502
ChainResidue
CGTP501
CHOH601
CHOH602
CHOH603
CHOH604

AD34binding site for residue CA C 503
ChainResidue
CASP39
CTHR41
CGLY44
CGLU55

AD418binding site for residue GTP D 501
ChainResidue
DGLY10
DGLN11
DCYS12
DALA97
DGLY98
DASN99
DSER138
DGLY141
DGLY142
DTHR143
DGLY144
DVAL175
DSER176
DGLU181
DASN204
DTYR222
DASN226
DMG502

AD51binding site for residue MG D 502
ChainResidue
DGTP501

AD615binding site for residue 9LX D 503
ChainResidue
CTHR179
CVAL181
DVAL236
DCYS239
DLEU240
DLEU246
DASP249
DLYS252
DLEU253
DASN256
DVAL313
DVAL316
DLYS350
DTHR351
DALA352

AD716binding site for residue ACP F 401
ChainResidue
FLYS74
FLYS150
FGLN183
FLYS184
FLEU186
FLYS198
FASP200
FARG202
FARG222
FTHR241
FASN242
FASP318
FMET320
FILE330
FGLU331
FASN333

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
GTP_5zxh_A_50131GUANOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
AVAL9-ALA12GTP: GUANOSINE-5'-TRIPHOSPHATE
AGLN15-ILE16GTP: GUANOSINE-5'-TRIPHOSPHATE
AASP69GTP: GUANOSINE-5'-TRIPHOSPHATE
AASP98-ASN102GTP: GUANOSINE-5'-TRIPHOSPHATE
ASER140GTP: GUANOSINE-5'-TRIPHOSPHATE
AGLY142-GLY146GTP: GUANOSINE-5'-TRIPHOSPHATE
AILE171GTP: GUANOSINE-5'-TRIPHOSPHATE
APRO173-ALA174GTP: GUANOSINE-5'-TRIPHOSPHATE
AVAL177-THR179GTP: GUANOSINE-5'-TRIPHOSPHATE
AGLU183GTP: GUANOSINE-5'-TRIPHOSPHATE
AASN206GTP: GUANOSINE-5'-TRIPHOSPHATE
ATYR224GTP: GUANOSINE-5'-TRIPHOSPHATE
ALEU227-ASN228GTP: GUANOSINE-5'-TRIPHOSPHATE
AILE231GTP: GUANOSINE-5'-TRIPHOSPHATE
BLYS252GTP: GUANOSINE-5'-TRIPHOSPHATE

9LX_5zxh_B_506282-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol binding site
ChainResidueligand
ASER178-VAL1819LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BTYR2009LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BGLY235-THR2379LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BCYS239-LEU2409LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BLEU2469LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BALA248-LEU2509LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BLYS252-LEU2539LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BASN256-MET2579LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BTHR312-VAL3169LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BASN3489LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BLYS350-ALA3529LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
BILE3689LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol

MES_5zxh_B_503122-(N-MORPHOLINO)-ETHANESULFONIC ACID binding site
ChainResidueligand
ATRP407MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BARG156MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BPRO160-MET164MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BGLU194-ASP197MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BARG251MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

GDP_5zxh_B_50130GUANOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
BALA9-GLY13GDP: GUANOSINE-5'-DIPHOSPHATE
BGLN15-ILE16GDP: GUANOSINE-5'-DIPHOSPHATE
BASP67GDP: GUANOSINE-5'-DIPHOSPHATE
BALA97GDP: GUANOSINE-5'-DIPHOSPHATE
BASN99GDP: GUANOSINE-5'-DIPHOSPHATE
BSER138GDP: GUANOSINE-5'-DIPHOSPHATE
BGLY140-SER145GDP: GUANOSINE-5'-DIPHOSPHATE
BVAL169GDP: GUANOSINE-5'-DIPHOSPHATE
BPRO171-SER172GDP: GUANOSINE-5'-DIPHOSPHATE
BVAL175-ASP177GDP: GUANOSINE-5'-DIPHOSPHATE
BGLU181GDP: GUANOSINE-5'-DIPHOSPHATE
BASN204GDP: GUANOSINE-5'-DIPHOSPHATE
BLEU207GDP: GUANOSINE-5'-DIPHOSPHATE
BTYR222GDP: GUANOSINE-5'-DIPHOSPHATE
BLEU225-ASN226GDP: GUANOSINE-5'-DIPHOSPHATE
BVAL229GDP: GUANOSINE-5'-DIPHOSPHATE

MES_5zxh_B_505112-(N-MORPHOLINO)-ETHANESULFONIC ACID binding site
ChainResidueligand
BPHE294-SER296MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BASP304-ARG306MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BTYR310MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BVAL333MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BASN337MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
BTYR340-PHE341MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

GTP_5zxh_C_50132GUANOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
CVAL9-ALA12GTP: GUANOSINE-5'-TRIPHOSPHATE
CGLN15-ILE16GTP: GUANOSINE-5'-TRIPHOSPHATE
CASP69GTP: GUANOSINE-5'-TRIPHOSPHATE
CASP98-ASN102GTP: GUANOSINE-5'-TRIPHOSPHATE
CSER140GTP: GUANOSINE-5'-TRIPHOSPHATE
CGLY142-SER147GTP: GUANOSINE-5'-TRIPHOSPHATE
CILE171GTP: GUANOSINE-5'-TRIPHOSPHATE
CPRO173-ALA174GTP: GUANOSINE-5'-TRIPHOSPHATE
CVAL177-THR179GTP: GUANOSINE-5'-TRIPHOSPHATE
CGLU183GTP: GUANOSINE-5'-TRIPHOSPHATE
CASN206GTP: GUANOSINE-5'-TRIPHOSPHATE
CTYR224GTP: GUANOSINE-5'-TRIPHOSPHATE
CLEU227-ASN228GTP: GUANOSINE-5'-TRIPHOSPHATE
CILE231GTP: GUANOSINE-5'-TRIPHOSPHATE
DLYS252GTP: GUANOSINE-5'-TRIPHOSPHATE

9LX_5zxh_D_503282-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol binding site
ChainResidueligand
CSER178-VAL1819LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DTYR2009LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DVAL2369LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DCYS239-LEU2409LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DLEU2469LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DALA248-LEU2509LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DLYS252-LEU2539LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DASN256-MET2579LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DTHR312-VAL3169LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DASN347-ALA3529LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
DILE3689LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol

GTP_5zxh_D_50131GUANOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
DGLY10-GLY13GTP: GUANOSINE-5'-TRIPHOSPHATE
DGLN15-ILE16GTP: GUANOSINE-5'-TRIPHOSPHATE
DASP67GTP: GUANOSINE-5'-TRIPHOSPHATE
DGLY96-ASN100GTP: GUANOSINE-5'-TRIPHOSPHATE
DSER138GTP: GUANOSINE-5'-TRIPHOSPHATE
DGLY140-SER145GTP: GUANOSINE-5'-TRIPHOSPHATE
DVAL169GTP: GUANOSINE-5'-TRIPHOSPHATE
DPRO171-SER172GTP: GUANOSINE-5'-TRIPHOSPHATE
DVAL175-SER176GTP: GUANOSINE-5'-TRIPHOSPHATE
DGLU181GTP: GUANOSINE-5'-TRIPHOSPHATE
DASN204GTP: GUANOSINE-5'-TRIPHOSPHATE
DLEU207GTP: GUANOSINE-5'-TRIPHOSPHATE
DTYR222GTP: GUANOSINE-5'-TRIPHOSPHATE
DLEU225-ASN226GTP: GUANOSINE-5'-TRIPHOSPHATE
DVAL229GTP: GUANOSINE-5'-TRIPHOSPHATE

ACP_5zxh_F_40122PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER binding site
ChainResidueligand
FLYS74ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FPRO95ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FILE148ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FLYS150ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FGLN183-LEU186ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FLYS198-ASP200ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FARG202ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FARG222ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FHIS239-ASN242ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FASP318ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FMET320ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FILE330-GLU331ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FASN333ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails