5ZX5

3.3 angstrom structure of mouse TRPM7 with EDTA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0051262	biological_process	protein tetramerization
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0051262	biological_process	protein tetramerization
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0051262	biological_process	protein tetramerization
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0051262	biological_process	protein tetramerization
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue Y01 A 1301

Chain	Residue
A	SER1013
A	PHE1014
A	TYR1080
B	TYR923
B	LEU977
B	VAL990
B	MET991
B	GLY994

---

site_id	AC2
Number of Residues	9
Details	binding site for residue Y01 A 1302

Chain	Residue
A	LEU977
A	VAL990
A	MET991
A	GLY994
A	VAL1110
A	GLN1114
D	SER1013
D	PHE1014
A	TYR923

---

site_id	AC3
Number of Residues	8
Details	binding site for residue Y01 A 1303

Chain	Residue
A	LEU1012
A	TRP1030
A	ALA1033
B	MET868
B	THR871
B	PHE872
B	TYR973
B	Y011302

---

site_id	AC4
Number of Residues	9
Details	binding site for residue Y01 A 1304

Chain	Residue
A	LEU864
A	MET868
A	THR871
A	PHE872
A	TYR973
A	Y011305
D	SER1029
D	TRP1030
D	ALA1033

---

site_id	AC5
Number of Residues	9
Details	binding site for residue Y01 A 1305

Chain	Residue
A	PHE856
A	TRP857
A	PHE979
A	LEU980
A	VAL982
A	ASN983
A	Y011304
D	LEU1009
D	LEU1012

---

site_id	AC6
Number of Residues	8
Details	binding site for residue Y01 B 1301

Chain	Residue
B	SER1013
B	LEU1076
B	TYR1080
C	PHE924
C	LEU977
C	VAL990
C	MET991
C	LYS995

---

site_id	AC7
Number of Residues	8
Details	binding site for residue Y01 B 1302

Chain	Residue
A	VAL1005
A	LEU1012
A	Y011303
B	TRP857
B	LEU864
B	LEU980
B	VAL982
B	ASN983

---

site_id	AC8
Number of Residues	8
Details	binding site for residue Y01 C 1301

Chain	Residue
B	SER1029
B	TRP1030
B	ALA1033
C	MET868
C	THR871
C	PHE872
C	TYR973
C	Y011302

---

site_id	AC9
Number of Residues	6
Details	binding site for residue Y01 C 1302

Chain	Residue
B	ALA1008
B	LEU1012
C	PHE856
C	PHE979
C	VAL982
C	Y011301

---

site_id	AD1
Number of Residues	6
Details	binding site for residue Y01 D 1301

Chain	Residue
C	SER1013
C	VAL1079
D	TYR923
D	VAL990
D	MET991
D	GLY994

---

site_id	AD2
Number of Residues	8
Details	binding site for residue Y01 D 1302

Chain	Residue
C	PRO1028
C	SER1029
C	TRP1030
C	ALA1033
D	THR871
D	PHE872
D	TYR973
D	Y011303

---

site_id	AD3
Number of Residues	8
Details	binding site for residue Y01 D 1303

Chain	Residue
C	LEU1012
D	TRP747
D	PHE856
D	TRP857
D	PHE979
D	VAL982
D	ASN983
D	Y011302

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	92
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	92
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	160
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"37156763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SI2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q96QT4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q96QT4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22222377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---