5ZX5

3.3 angstrom structure of mouse TRPM7 with EDTA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0051262	biological_process	protein tetramerization
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0051262	biological_process	protein tetramerization
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0051262	biological_process	protein tetramerization
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0051262	biological_process	protein tetramerization
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue Y01 A 1301

Chain	Residue
A	SER1013
A	PHE1014
A	TYR1080
B	TYR923
B	LEU977
B	VAL990
B	MET991
B	GLY994

---

site_id	AC2
Number of Residues	9
Details	binding site for residue Y01 A 1302

Chain	Residue
A	LEU977
A	VAL990
A	MET991
A	GLY994
A	VAL1110
A	GLN1114
D	SER1013
D	PHE1014
A	TYR923

---

site_id	AC3
Number of Residues	8
Details	binding site for residue Y01 A 1303

Chain	Residue
A	LEU1012
A	TRP1030
A	ALA1033
B	MET868
B	THR871
B	PHE872
B	TYR973
B	Y011302

---

site_id	AC4
Number of Residues	9
Details	binding site for residue Y01 A 1304

Chain	Residue
A	LEU864
A	MET868
A	THR871
A	PHE872
A	TYR973
A	Y011305
D	SER1029
D	TRP1030
D	ALA1033

---

site_id	AC5
Number of Residues	9
Details	binding site for residue Y01 A 1305

Chain	Residue
A	PHE856
A	TRP857
A	PHE979
A	LEU980
A	VAL982
A	ASN983
A	Y011304
D	LEU1009
D	LEU1012

---

site_id	AC6
Number of Residues	8
Details	binding site for residue Y01 B 1301

Chain	Residue
B	SER1013
B	LEU1076
B	TYR1080
C	PHE924
C	LEU977
C	VAL990
C	MET991
C	LYS995

---

site_id	AC7
Number of Residues	8
Details	binding site for residue Y01 B 1302

Chain	Residue
A	VAL1005
A	LEU1012
A	Y011303
B	TRP857
B	LEU864
B	LEU980
B	VAL982
B	ASN983

---

site_id	AC8
Number of Residues	8
Details	binding site for residue Y01 C 1301

Chain	Residue
B	SER1029
B	TRP1030
B	ALA1033
C	MET868
C	THR871
C	PHE872
C	TYR973
C	Y011302

---

site_id	AC9
Number of Residues	6
Details	binding site for residue Y01 C 1302

Chain	Residue
B	ALA1008
B	LEU1012
C	PHE856
C	PHE979
C	VAL982
C	Y011301

---

site_id	AD1
Number of Residues	6
Details	binding site for residue Y01 D 1301

Chain	Residue
C	SER1013
C	VAL1079
D	TYR923
D	VAL990
D	MET991
D	GLY994

---

site_id	AD2
Number of Residues	8
Details	binding site for residue Y01 D 1302

Chain	Residue
C	PRO1028
C	SER1029
C	TRP1030
C	ALA1033
D	THR871
D	PHE872
D	TYR973
D	Y011303

---

site_id	AD3
Number of Residues	8
Details	binding site for residue Y01 D 1303

Chain	Residue
C	LEU1012
D	TRP747
D	PHE856
D	TRP857
D	PHE979
D	VAL982
D	ASN983
D	Y011302

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ASN756-TYR776
B	LEU963-ASN983
B	MET996-VAL1016
B	PHE1075-PHE1095
C	ASN756-TYR776
C	PHE856-VAL876
C	TRP919-PHE939
C	LEU963-ASN983
C	MET996-VAL1016
C	PHE1075-PHE1095
D	ASN756-TYR776
A	PHE856-VAL876
D	PHE856-VAL876
D	TRP919-PHE939
D	LEU963-ASN983
D	MET996-VAL1016
D	PHE1075-PHE1095
A	TRP919-PHE939
A	LEU963-ASN983
A	MET996-VAL1016
A	PHE1075-PHE1095
B	ASN756-TYR776
B	PHE856-VAL876
B	TRP919-PHE939

---

site_id	SWS_FT_FI2
Number of Residues	540
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	LYS777-LYS855
C	GLY940-ARG962
C	PRO1017-ASP1035
C	ALA1057-PRO1074
D	LYS777-LYS855
D	GLY940-ARG962
D	PRO1017-ASP1035
D	ALA1057-PRO1074
A	GLY940-ARG962
A	PRO1017-ASP1035
A	ALA1057-PRO1074
B	LYS777-LYS855
B	GLY940-ARG962
B	PRO1017-ASP1035
B	ALA1057-PRO1074
C	LYS777-LYS855

---

site_id	SWS_FT_FI3
Number of Residues	208
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS877-VAL918
A	GLN984-LYS995
B	LYS877-VAL918
B	GLN984-LYS995
C	LYS877-VAL918
C	GLN984-LYS995
D	LYS877-VAL918
D	GLN984-LYS995

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	INTRAMEM: Pore-forming => ECO:0000255

Chain	Residue	Details
A	ILE1036-CYS1056
B	ILE1036-CYS1056
C	ILE1036-CYS1056
D	ILE1036-CYS1056

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96QT4

Chain	Residue	Details
A	SER101
B	SER101
C	SER101
D	SER101

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:22222377

Chain	Residue	Details
A	SER1224
B	SER1224
C	SER1224
D	SER1224

---