Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004503 | molecular_function | tyrosinase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004503 | molecular_function | tyrosinase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0004503 | molecular_function | tyrosinase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0004503 | molecular_function | tyrosinase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue CIT A 601 |
| Chain | Residue |
| A | LYS239 |
| A | LYS463 |
| A | ALA485 |
| A | HIS486 |
| A | THR255 |
| A | ALA258 |
| A | SER259 |
| A | ASN262 |
| A | VAL269 |
| A | THR270 |
| A | PRO271 |
| A | SER274 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | TYR62 |
| A | TYR77 |
| A | GLY79 |
| A | TYR168 |
| A | ARG468 |
| A | VAL471 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | PRO358 |
| A | GLY359 |
| A | PHE360 |
| A | GLU364 |
| A | PRO371 |
| A | ASN373 |
| A | HOH804 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | GLY23 |
| A | GLU24 |
| A | LYS25 |
| A | LYS26 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | TYR174 |
| A | VAL175 |
| A | VAL177 |
| A | HOH702 |
| A | HOH780 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CU A 606 |
| Chain | Residue |
| A | HIS56 |
| A | CYS82 |
| A | HIS84 |
| A | HIS93 |
| A | O608 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CU A 607 |
| Chain | Residue |
| A | HIS276 |
| A | HIS280 |
| A | PHE315 |
| A | HIS319 |
| A | O608 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue O A 608 |
| Chain | Residue |
| A | HIS56 |
| A | HIS84 |
| A | HIS93 |
| A | HIS276 |
| A | HIS280 |
| A | ASN306 |
| A | HIS319 |
| A | CU606 |
| A | CU607 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue CIT B 601 |
| Chain | Residue |
| B | LYS239 |
| B | THR255 |
| B | ALA258 |
| B | SER259 |
| B | ASN262 |
| B | THR270 |
| B | PRO271 |
| B | SER274 |
| B | LYS463 |
| B | ALA485 |
| B | HIS486 |
| B | HOH767 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | ARG14 |
| B | LYS125 |
| B | HOH763 |
| B | HOH801 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | GLY359 |
| B | GLU364 |
| B | PRO371 |
| B | ASN373 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| A | ARG393 |
| B | LYS195 |
| C | GLU192 |
| C | LYS195 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | TYR77 |
| B | GLY79 |
| B | TYR168 |
| B | ARG468 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CU B 606 |
| Chain | Residue |
| B | HIS276 |
| B | HIS280 |
| B | PHE315 |
| B | HIS319 |
| B | O608 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CU B 607 |
| Chain | Residue |
| B | HIS56 |
| B | CYS82 |
| B | HIS84 |
| B | HIS93 |
| B | O608 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue O B 608 |
| Chain | Residue |
| B | HIS56 |
| B | HIS84 |
| B | HIS276 |
| B | HIS280 |
| B | HIS319 |
| B | CU606 |
| B | CU607 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue CIT C 601 |
| Chain | Residue |
| C | THR255 |
| C | SER259 |
| C | ASN262 |
| C | THR270 |
| C | PRO271 |
| C | SER274 |
| C | LYS463 |
| C | ALA485 |
| C | HIS486 |
| C | HOH775 |
| C | LYS239 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 602 |
| Chain | Residue |
| C | HIS197 |
| C | LYS200 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 603 |
| Chain | Residue |
| C | GLN435 |
| C | GLN437 |
| C | HIS508 |
| C | GLY510 |
| C | GLY511 |
| C | ALA520 |
| C | HOH727 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue CU C 604 |
| Chain | Residue |
| C | HIS276 |
| C | HIS280 |
| C | PHE315 |
| C | HIS319 |
| C | O606 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue CU C 605 |
| Chain | Residue |
| C | HIS56 |
| C | CYS82 |
| C | HIS84 |
| C | HIS93 |
| C | O606 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue O C 606 |
| Chain | Residue |
| C | HIS84 |
| C | HIS93 |
| C | HIS276 |
| C | HIS280 |
| C | HIS319 |
| C | CU604 |
| C | CU605 |
| site_id | AE5 |
| Number of Residues | 11 |
| Details | binding site for residue CIT D 601 |
| Chain | Residue |
| D | LYS239 |
| D | THR255 |
| D | ALA258 |
| D | SER259 |
| D | ASN262 |
| D | THR270 |
| D | PRO271 |
| D | SER274 |
| D | LYS463 |
| D | ALA485 |
| D | HIS486 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 602 |
| Chain | Residue |
| C | SER419 |
| D | GLY23 |
| D | GLU24 |
| D | LYS25 |
| D | LYS26 |
| D | HOH712 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 603 |
| Chain | Residue |
| D | GLY359 |
| D | GLU364 |
| D | PRO371 |
| D | ASN373 |
| D | HOH727 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 604 |
| Chain | Residue |
| D | ALA156 |
| D | LEU157 |
| D | SER158 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 605 |
| Chain | Residue |
| D | LYS172 |
| D | TYR174 |
| D | VAL175 |
| D | HOH742 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue CU D 606 |
| Chain | Residue |
| D | HIS56 |
| D | CYS82 |
| D | HIS84 |
| D | HIS93 |
| D | O608 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 607 |
| Chain | Residue |
| D | HIS276 |
| D | HIS280 |
| D | HIS319 |
| D | O608 |
| site_id | AF3 |
| Number of Residues | 9 |
| Details | binding site for residue O D 608 |
| Chain | Residue |
| D | HIS56 |
| D | HIS84 |
| D | HIS93 |
| D | HIS276 |
| D | HIS280 |
| D | ASN306 |
| D | HIS319 |
| D | CU606 |
| D | CU607 |
| site_id | AF4 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide CYS B 82 and HIS B 84 |
| Chain | Residue |
| B | HIS56 |
| B | TRP78 |
| B | GLY80 |
| B | TYR81 |
| B | ASN83 |
| B | GLY85 |
| B | ASN86 |
| B | TRP92 |
| B | HIS93 |
| B | GLU273 |
| B | ASN306 |
| B | SER353 |
| B | GLN354 |
| B | CU607 |
| B | O608 |
| site_id | AF5 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide CYS C 82 and HIS C 84 |
| Chain | Residue |
| C | HIS56 |
| C | TRP78 |
| C | GLY80 |
| C | TYR81 |
| C | ASN83 |
| C | GLY85 |
| C | ASN86 |
| C | TRP92 |
| C | HIS93 |
| C | GLU273 |
| C | GLN354 |
| C | THR357 |
| C | CU605 |
| C | O606 |
| site_id | AF6 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide CYS D 82 and HIS D 84 |
| Chain | Residue |
| D | HIS56 |
| D | TRP78 |
| D | GLY80 |
| D | TYR81 |
| D | ASN83 |
| D | GLY85 |
| D | ASN86 |
| D | TRP92 |
| D | HIS93 |
| D | GLU273 |
| D | ASN306 |
| D | SER353 |
| D | GLN354 |
| D | THR357 |
| D | CU606 |
| D | O608 |
Functional Information from PROSITE/UniProt
| site_id | PS00497 |
| Number of Residues | 18 |
| Details | TYROSINASE_1 Tyrosinase CuA-binding region signature. Hgnvl.FPtWHRmyVyklE |
| Chain | Residue | Details |
| A | HIS84-GLU101 | |
| site_id | PS00498 |
| Number of Residues | 12 |
| Details | TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPiFFfhHcnvD |
| Chain | Residue | Details |
| A | ASP312-ASP323 | |
