5ZON

Histidinol phosphate phosphatase from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0004401	molecular_function	histidinol-phosphatase activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008652	biological_process	amino acid biosynthetic process
A	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
A	0010125	biological_process	mycothiol biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000105	biological_process	L-histidine biosynthetic process
B	0004401	molecular_function	histidinol-phosphatase activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008652	biological_process	amino acid biosynthetic process
B	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
B	0010125	biological_process	mycothiol biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0042578	molecular_function	phosphoric ester hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000105	biological_process	L-histidine biosynthetic process
C	0004401	molecular_function	histidinol-phosphatase activity
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008652	biological_process	amino acid biosynthetic process
C	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
C	0010125	biological_process	mycothiol biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0042578	molecular_function	phosphoric ester hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000105	biological_process	L-histidine biosynthetic process
D	0004401	molecular_function	histidinol-phosphatase activity
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008652	biological_process	amino acid biosynthetic process
D	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
D	0010125	biological_process	mycothiol biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ZN A 301

Chain	Residue
A	ASP44
A	GLU67
A	GLU68
A	ASP83
A	ILE85
A	PO4303
A	HOH441

---

site_id	AC2
Number of Residues	7
Details	binding site for residue ZN A 302

Chain	Residue
A	ASP86
A	ASP213
A	PO4303
A	HOH435
A	HOH487
A	GLU67
A	ASP83

---

site_id	AC3
Number of Residues	12
Details	binding site for residue PO4 A 303

Chain	Residue
A	ASP44
A	GLU67
A	ASP83
A	ILE85
A	ASP86
A	GLY87
A	THR88
A	ZN301
A	ZN302
A	HOH435
A	HOH487
A	HOH511

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PO4 B 301

Chain	Residue
A	SER161
B	ARG183
B	ARG185
B	HOH419
B	HOH433
B	HOH489

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN B 302

Chain	Residue
B	ASP86
B	ASP189
B	ASP213
B	PO4304
B	HOH429

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 303

Chain	Residue
B	ASP83
B	ASP86
B	ASP213
B	PO4304

---

site_id	AC7
Number of Residues	11
Details	binding site for residue PO4 B 304

Chain	Residue
B	ILE85
B	ASP86
B	GLY87
B	THR88
B	ASP189
B	ASP213
B	ZN302
B	ZN303
B	HOH403
B	HOH427
B	HOH508

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PO4 B 305

Chain	Residue
A	ARG183
A	ARG185
B	SER161
B	HOH402
B	HOH482

---

site_id	AC9
Number of Residues	7
Details	binding site for residue ZN C 301

Chain	Residue
C	GLU67
C	ASP83
C	ASP86
C	ASP213
C	PO4304
C	HOH449
C	HOH508

---

site_id	AD1
Number of Residues	7
Details	binding site for residue ZN C 302

Chain	Residue
C	ASP44
C	GLU67
C	GLU68
C	ASP83
C	ILE85
C	PO4304
C	HOH422

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PO4 C 303

Chain	Residue
C	SER161
C	HOH415
C	HOH537
D	ARG185

---

site_id	AD3
Number of Residues	13
Details	binding site for residue PO4 C 304

Chain	Residue
C	ASP44
C	GLU67
C	ASP83
C	ILE85
C	ASP86
C	GLY87
C	THR88
C	ZN301
C	ZN302
C	HOH408
C	HOH422
C	HOH508
C	HOH513

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL C 305

Chain	Residue
A	THR73
A	HOH409
C	ARG23
C	ASP42
C	LEU254
C	ASN258
C	HOH420

---

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL C 306

Chain	Residue
C	HOH457
C	ALA166
C	GLY169
C	ARG171
C	GLU172

---

site_id	AD6
Number of Residues	5
Details	binding site for residue ZN D 301

Chain	Residue
D	ASP86
D	ASP189
D	ASP213
D	PO4303
D	HOH411

---

site_id	AD7
Number of Residues	5
Details	binding site for residue ZN D 302

Chain	Residue
D	ASP83
D	ASP86
D	ASP213
D	HOH411
D	HOH454

---

site_id	AD8
Number of Residues	8
Details	binding site for residue PO4 D 303

Chain	Residue
D	ASP86
D	GLY87
D	THR88
D	LYS89
D	ASP189
D	ZN301
D	HOH411
D	HOH431

---

site_id	AD9
Number of Residues	5
Details	binding site for residue PO4 D 304

Chain	Residue
C	ARG183
C	ARG185
D	SER161
D	HOH403
D	HOH498

---

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	14
Details	IMP_1 Inositol monophosphatase family signature 1. WiVDPIDGTknFvR

Chain	Residue	Details
A	TRP80-ARG93

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---