5ZON
Histidinol phosphate phosphatase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0004401 | molecular_function | histidinol-phosphatase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| A | 0010125 | biological_process | mycothiol biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0004401 | molecular_function | histidinol-phosphatase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| B | 0010125 | biological_process | mycothiol biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000105 | biological_process | L-histidine biosynthetic process |
| C | 0004401 | molecular_function | histidinol-phosphatase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| C | 0010125 | biological_process | mycothiol biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016791 | molecular_function | phosphatase activity |
| C | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000105 | biological_process | L-histidine biosynthetic process |
| D | 0004401 | molecular_function | histidinol-phosphatase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| D | 0010125 | biological_process | mycothiol biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016791 | molecular_function | phosphatase activity |
| D | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | ASP44 |
| A | GLU67 |
| A | GLU68 |
| A | ASP83 |
| A | ILE85 |
| A | PO4303 |
| A | HOH441 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | ASP86 |
| A | ASP213 |
| A | PO4303 |
| A | HOH435 |
| A | HOH487 |
| A | GLU67 |
| A | ASP83 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 A 303 |
| Chain | Residue |
| A | ASP44 |
| A | GLU67 |
| A | ASP83 |
| A | ILE85 |
| A | ASP86 |
| A | GLY87 |
| A | THR88 |
| A | ZN301 |
| A | ZN302 |
| A | HOH435 |
| A | HOH487 |
| A | HOH511 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| A | SER161 |
| B | ARG183 |
| B | ARG185 |
| B | HOH419 |
| B | HOH433 |
| B | HOH489 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | ASP86 |
| B | ASP189 |
| B | ASP213 |
| B | PO4304 |
| B | HOH429 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | ASP83 |
| B | ASP86 |
| B | ASP213 |
| B | PO4304 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 B 304 |
| Chain | Residue |
| B | ILE85 |
| B | ASP86 |
| B | GLY87 |
| B | THR88 |
| B | ASP189 |
| B | ASP213 |
| B | ZN302 |
| B | ZN303 |
| B | HOH403 |
| B | HOH427 |
| B | HOH508 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 B 305 |
| Chain | Residue |
| A | ARG183 |
| A | ARG185 |
| B | SER161 |
| B | HOH402 |
| B | HOH482 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | GLU67 |
| C | ASP83 |
| C | ASP86 |
| C | ASP213 |
| C | PO4304 |
| C | HOH449 |
| C | HOH508 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN C 302 |
| Chain | Residue |
| C | ASP44 |
| C | GLU67 |
| C | GLU68 |
| C | ASP83 |
| C | ILE85 |
| C | PO4304 |
| C | HOH422 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 C 303 |
| Chain | Residue |
| C | SER161 |
| C | HOH415 |
| C | HOH537 |
| D | ARG185 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for residue PO4 C 304 |
| Chain | Residue |
| C | ASP44 |
| C | GLU67 |
| C | ASP83 |
| C | ILE85 |
| C | ASP86 |
| C | GLY87 |
| C | THR88 |
| C | ZN301 |
| C | ZN302 |
| C | HOH408 |
| C | HOH422 |
| C | HOH508 |
| C | HOH513 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 305 |
| Chain | Residue |
| A | THR73 |
| A | HOH409 |
| C | ARG23 |
| C | ASP42 |
| C | LEU254 |
| C | ASN258 |
| C | HOH420 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 306 |
| Chain | Residue |
| C | HOH457 |
| C | ALA166 |
| C | GLY169 |
| C | ARG171 |
| C | GLU172 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | ASP86 |
| D | ASP189 |
| D | ASP213 |
| D | PO4303 |
| D | HOH411 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 302 |
| Chain | Residue |
| D | ASP83 |
| D | ASP86 |
| D | ASP213 |
| D | HOH411 |
| D | HOH454 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 D 303 |
| Chain | Residue |
| D | ASP86 |
| D | GLY87 |
| D | THR88 |
| D | LYS89 |
| D | ASP189 |
| D | ZN301 |
| D | HOH411 |
| D | HOH431 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 304 |
| Chain | Residue |
| C | ARG183 |
| C | ARG185 |
| D | SER161 |
| D | HOH403 |
| D | HOH498 |
Functional Information from PROSITE/UniProt
| site_id | PS00629 |
| Number of Residues | 14 |
| Details | IMP_1 Inositol monophosphatase family signature 1. WiVDPIDGTknFvR |
| Chain | Residue | Details |
| A | TRP80-ARG93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU67 | |
| B | ASP86 | |
| B | ARG185 | |
| B | ASP213 | |
| C | GLU67 | |
| C | ASP83 | |
| C | ILE85 | |
| C | ASP86 | |
| C | ARG185 | |
| C | ASP213 | |
| D | GLU67 | |
| A | ASP83 | |
| D | ASP83 | |
| D | ILE85 | |
| D | ASP86 | |
| D | ARG185 | |
| D | ASP213 | |
| A | ILE85 | |
| A | ASP86 | |
| A | ARG185 | |
| A | ASP213 | |
| B | GLU67 | |
| B | ASP83 | |
| B | ILE85 |
