5ZML
Stapled-peptides tailored against initiation of translation
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue NO3 A 901 |
| Chain | Residue |
| A | LYS95 |
| A | LYS106 |
| A | ASP147 |
| A | VAL149 |
| A | CYS150 |
| A | THR168 |
| A | HOH1038 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 902 |
| Chain | Residue |
| A | SER92 |
| A | PRO100 |
| A | HOH1009 |
| A | HOH1122 |
| A | PHE48 |
| A | ASP90 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 903 |
| Chain | Residue |
| A | THR116 |
| A | GLN121 |
| A | HOH1007 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 904 |
| Chain | Residue |
| A | ARG122 |
| A | ARG123 |
| A | SER124 |
| A | ASP125 |
| A | LEU126 |
| A | ASP127 |
| A | ARG128 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residues MK8 B 8 and MK8 B 12 |
| Chain | Residue |
| A | HIS178 |
| A | ARG181 |
| A | VAL182 |
| A | GLU185 |
| B | SER6 |
| B | ARG7 |
| B | GLN9 |
| B | LEU10 |
| B | LEU11 |
| B | PHE13 |
| B | ARG14 |
| B | ARG15 |
| B | HOH109 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"11154262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25923732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7665584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7782323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
