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5ZML

Stapled-peptides tailored against initiation of translation

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue NO3 A 901
ChainResidue
ALYS95
ALYS106
AASP147
AVAL149
ACYS150
ATHR168
AHOH1038

site_idAC2
Number of Residues6
Detailsbinding site for residue EDO A 902
ChainResidue
ASER92
APRO100
AHOH1009
AHOH1122
APHE48
AASP90

site_idAC3
Number of Residues3
Detailsbinding site for residue EDO A 903
ChainResidue
ATHR116
AGLN121
AHOH1007

site_idAC4
Number of Residues7
Detailsbinding site for residue EDO A 904
ChainResidue
AARG122
AARG123
ASER124
AASP125
ALEU126
AASP127
AARG128

site_idAC5
Number of Residues13
Detailsbinding site for residues MK8 B 8 and MK8 B 12
ChainResidue
AHIS178
AARG181
AVAL182
AGLU185
BSER6
BARG7
BGLN9
BLEU10
BLEU11
BPHE13
BARG14
BARG15
BHOH109

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11879179, ECO:0000269|PubMed:12975586, ECO:0000269|PubMed:16271312
ChainResidueDetails
ATRP56
ATRP102
AARG157
ATHR205

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: (Microbial infection) Interaction with potato virus Y VPg => ECO:0000269|PubMed:31712417
ChainResidueDetails
ALYS159

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323
ChainResidueDetails
ASER209

226707

PDB entries from 2024-10-30

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