5ZLM

Mutation in the trinuclear site of CotA-laccase: H491C mutant, PH 8.0

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0030435	biological_process	sporulation resulting in formation of a cellular spore
A	0046872	molecular_function	metal ion binding
A	0047705	molecular_function	bilirubin oxidase activity
A	0052716	molecular_function	hydroquinone:oxygen oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CU A 601

Chain	Residue
A	HIS419
A	CYS492
A	HIS497
A	MET502

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CU A 602

Chain	Residue
A	HIS105
A	HIS107
A	HIS422
A	HIS424
A	HOH932

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CU A 603

Chain	Residue
A	HIS107
A	HIS153
A	HIS493
A	HOH1168

---

site_id	AC4
Number of Residues	10
Details	binding site for residue GOL A 604

Chain	Residue
A	ASP113
A	ASP114
A	TYR118
A	ALA121
A	TYR133
A	LYS135
A	ARG487
A	EDO613
A	HOH806
A	HOH1055

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 605

Chain	Residue
A	ASN75
A	LEU76
A	PRO77
A	LYS125
A	GLN367
A	ASN368
A	HOH741
A	HOH764

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 606

Chain	Residue
A	GLU188
A	GLU244
A	TYR250
A	HOH712
A	HOH721
A	HOH1106

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 607

Chain	Residue
A	PHE292
A	SER293
A	TYR300
A	PRO457
A	SER459
A	HOH780
A	HOH977

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 608

Chain	Residue
A	ASP268
A	ALA317
A	PRO328
A	ASN333
A	HOH723
A	HOH727
A	HOH994

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 609

Chain	Residue
A	GLY108
A	ALA148
A	LEU150
A	ASP279
A	GLY280
A	SER427
A	ASP465
A	HOH896

---

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO A 610

Chain	Residue
A	ASN74
A	LEU76
A	PRO77
A	SER78
A	VAL100
A	SER124
A	LYS125
A	HOH1140

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 611

Chain	Residue
A	LYS25
A	TYR69
A	THR307
A	ALA308
A	TYR309
A	GLU310
A	HOH918

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 612

Chain	Residue
A	ARG136
A	GLU137
A	VAL138
A	PRO247
A	LEU343
A	HOH742
A	HOH1065

---

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO A 613

Chain	Residue
A	ASP113
A	ASP114
A	LYS135
A	LEU343
A	GOL604
A	EDO614
A	HOH788

---

site_id	AD5
Number of Residues	7
Details	binding site for residue EDO A 614

Chain	Residue
A	PRO112
A	ASP113
A	TYR484
A	SER485
A	TYR488
A	EDO613
A	HOH749

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Domain: {"description":"Plastocyanin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	77
Details	Domain: {"description":"Plastocyanin-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Domain: {"description":"Plastocyanin-like 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	131
Details	Domain: {"description":"Plastocyanin-like 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"description":"type 2 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"description":"type 3 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Plays a crucial role in the protonation steps","evidences":[{"source":"PubMed","id":"22481612","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Site: {"description":"Plays a crucial role in the protonation steps","evidences":[{"source":"PubMed","id":"20200715","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22481612","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---