5ZKO

Crystal structure of the CRTC2-CREB-CRE complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0008140	molecular_function	cAMP response element binding protein binding
G	0032793	biological_process	positive regulation of CREB transcription factor activity
G	0051289	biological_process	protein homotetramerization
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0008140	molecular_function	cAMP response element binding protein binding
H	0032793	biological_process	positive regulation of CREB transcription factor activity
H	0051289	biological_process	protein homotetramerization

Functional Information from PROSITE/UniProt

site_id	PS00036
Number of Residues	15
Details	BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. Rlm.KNReAAREcRRK

Chain	Residue	Details
A	ARG289-LYS303

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Region: {"description":"Leucine-zipper","evidences":[{"source":"PROSITE-ProRule","id":"PRU00978","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Required for binding TORCs"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"12552083","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Asymmetric dimethylarginine; by PRMT6","evidences":[{"source":"PubMed","id":"24570487","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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