5ZJM

Crystal structure of N-acetylneuraminate lyase from Fusobacterium nucleatum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008747	molecular_function	N-acetylneuraminate lyase activity
A	0016829	molecular_function	lyase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008747	molecular_function	N-acetylneuraminate lyase activity
B	0016829	molecular_function	lyase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0008747	molecular_function	N-acetylneuraminate lyase activity
C	0016829	molecular_function	lyase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0008747	molecular_function	N-acetylneuraminate lyase activity
D	0016829	molecular_function	lyase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 301

Chain	Residue
A	ASN13
A	ILE18
A	ASN19
A	GLU20
A	LYS21

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO B 301

Chain	Residue
B	LYS21
B	ASN13
B	ILE18
B	ASN19
B	GLU20

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO C 301

Chain	Residue
C	ASN13
C	ILE18
C	ASN19
C	GLU20
C	LYS21

---

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. GLYvgGSTGENfmisteE

Chain	Residue	Details
A	GLY38-GLU55

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site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YSIPflTgvnMslsqfgelfenek.IiGVKFT

Chain	Residue	Details
A	TYR133-THR163

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01237

Chain	Residue	Details
A	TYR133
B	TYR133
C	TYR133
D	TYR133

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000305|PubMed:30387778

Chain	Residue	Details
A	LYS161
B	LYS161
C	LYS161
D	LYS161

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01237

Chain	Residue	Details
A	SER44
B	THR163
B	GLY185
B	ASP187
B	GLU188
B	SER204
C	SER44
C	THR45
C	THR163
C	GLY185
C	ASP187
A	THR45
C	GLU188
C	SER204
D	SER44
D	THR45
D	THR163
D	GLY185
D	ASP187
D	GLU188
D	SER204
A	THR163
A	GLY185
A	ASP187
A	GLU188
A	SER204
B	SER44
B	THR45

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