5ZGI

Crystal structure of NDM-1 at pH6.5 (Succinate) with 1 molecule per asymmetric unit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS120
A	HIS122
A	HIS189
A	OH303

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site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 302

Chain	Residue
A	ASP124
A	CYS208
A	HIS250
A	OH303
A	SIN306

---

site_id	AC3
Number of Residues	8
Details	binding site for residue OH A 303

Chain	Residue
A	HIS120
A	HIS122
A	ASP124
A	HIS189
A	CYS208
A	ZN301
A	ZN302
A	SIN306

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 304

Chain	Residue
A	THR94
A	GLN123
A	HOH430
A	HOH441

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 305

Chain	Residue
A	LYS106
A	ASN110
A	LEU111
A	PRO112
A	HOH410
A	HOH435

---

site_id	AC6
Number of Residues	9
Details	binding site for residue SIN A 306

Chain	Residue
A	ASP124
A	HIS189
A	ASN220
A	HIS250
A	ZN302
A	OH303
A	HOH530
A	HOH540
A	HOH601

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 307

Chain	Residue
A	HIS133
A	GLY237
A	ARG256
A	ILE259
A	HOH444
A	HOH455

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530

Chain	Residue	Details
A	ASP124
A	HIS189
A	CYS208
A	HIS250
A	HIS120
A	HIS122

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22713171

Chain	Residue	Details
A	ASN220
A	LYS211

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