Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
A | 0051287 | molecular_function | NAD binding |
A | 0070403 | molecular_function | NAD+ binding |
B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
B | 0051287 | molecular_function | NAD binding |
B | 0070403 | molecular_function | NAD+ binding |
C | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
C | 0051287 | molecular_function | NAD binding |
C | 0070403 | molecular_function | NAD+ binding |
D | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
D | 0051287 | molecular_function | NAD binding |
D | 0070403 | molecular_function | NAD+ binding |
E | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
E | 0051287 | molecular_function | NAD binding |
E | 0070403 | molecular_function | NAD+ binding |
F | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
F | 0051287 | molecular_function | NAD binding |
F | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 401 |
Chain | Residue |
A | CYS256 |
A | CYS259 |
A | CYS280 |
A | CYS283 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 401 |
Chain | Residue |
B | CYS256 |
B | CYS259 |
B | CYS280 |
B | CYS283 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN C 401 |
Chain | Residue |
C | CYS259 |
C | CYS280 |
C | CYS283 |
C | CYS256 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN D 401 |
Chain | Residue |
D | CYS256 |
D | CYS259 |
D | CYS280 |
D | CYS283 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN E 401 |
Chain | Residue |
E | CYS256 |
E | CYS259 |
E | CYS280 |
E | CYS283 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for Di-peptide ALA G 15 and KHB G 16 |
Chain | Residue |
A | PHE180 |
A | GLN228 |
A | HIS248 |
A | VAL292 |
A | PHE293 |
A | PHE294 |
A | GLY295 |
A | GLU296 |
A | GLU325 |
G | GLY14 |
G | ARG17 |
site_id | AC7 |
Number of Residues | 14 |
Details | binding site for Di-peptide KHB G 16 and ARG G 17 |
Chain | Residue |
A | PHE180 |
A | GLN228 |
A | HIS248 |
A | VAL292 |
A | PHE293 |
A | PHE294 |
A | GLY295 |
A | GLU296 |
A | VAL324 |
A | GLU325 |
G | GLY13 |
G | GLY14 |
G | ALA15 |
G | HIS18 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for Di-peptide ALA H 15 and KHB H 16 |
Chain | Residue |
B | PHE180 |
B | GLN228 |
B | ILE230 |
B | HIS248 |
B | VAL292 |
B | PHE293 |
B | PHE294 |
B | GLY295 |
B | GLU296 |
B | GLU325 |
H | GLY14 |
H | ARG17 |
site_id | AC9 |
Number of Residues | 15 |
Details | binding site for Di-peptide KHB H 16 and ARG H 17 |
Chain | Residue |
B | PHE180 |
B | GLN228 |
B | ILE230 |
B | HIS248 |
B | VAL292 |
B | PHE293 |
B | PHE294 |
B | GLY295 |
B | GLU296 |
B | VAL324 |
B | GLU325 |
H | LYS12 |
H | GLY13 |
H | ALA15 |
H | HIS18 |
site_id | AD1 |
Number of Residues | 14 |
Details | binding site for Di-peptide ALA I 15 and KHB I 16 |
Chain | Residue |
C | PHE180 |
C | GLN228 |
C | ILE230 |
C | HIS248 |
C | VAL292 |
C | PHE293 |
C | PHE294 |
C | GLY295 |
C | GLU296 |
C | VAL324 |
C | GLU325 |
I | GLY14 |
I | ARG17 |
I | HOH101 |
site_id | AD2 |
Number of Residues | 15 |
Details | binding site for Di-peptide KHB I 16 and ARG I 17 |
Chain | Residue |
I | HIS18 |
I | HOH101 |
C | PHE180 |
C | GLN228 |
C | ILE230 |
C | HIS248 |
C | VAL292 |
C | PHE293 |
C | PHE294 |
C | GLY295 |
C | GLU296 |
C | VAL324 |
C | GLU325 |
I | GLY13 |
I | ALA15 |
site_id | AD3 |
Number of Residues | 13 |
Details | binding site for Di-peptide ALA J 15 and KHB J 16 |
Chain | Residue |
E | PHE180 |
E | GLN228 |
E | ILE230 |
E | HIS248 |
E | VAL292 |
E | PHE293 |
E | PHE294 |
E | GLY295 |
E | GLU296 |
E | VAL324 |
E | GLU325 |
J | GLY14 |
J | ARG17 |
site_id | AD4 |
Number of Residues | 13 |
Details | binding site for Di-peptide KHB J 16 and ARG J 17 |
Chain | Residue |
E | PHE180 |
E | GLN228 |
E | ILE230 |
E | HIS248 |
E | VAL292 |
E | PHE293 |
E | PHE294 |
E | GLY295 |
E | GLU296 |
E | VAL324 |
E | GLU325 |
J | ALA15 |
J | HIS18 |
site_id | AD5 |
Number of Residues | 11 |
Details | binding site for Di-peptide ALA K 15 and KHB K 16 |
Chain | Residue |
D | PHE180 |
D | GLN228 |
D | HIS248 |
D | VAL292 |
D | PHE293 |
D | PHE294 |
D | GLY295 |
D | GLU296 |
D | GLU325 |
K | GLY14 |
K | ARG17 |
site_id | AD6 |
Number of Residues | 11 |
Details | binding site for Di-peptide KHB K 16 and ARG K 17 |
Chain | Residue |
D | PHE180 |
D | GLN228 |
D | HIS248 |
D | VAL292 |
D | PHE293 |
D | PHE294 |
D | GLY295 |
D | GLU296 |
D | GLU325 |
K | ALA15 |
K | HIS18 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for Di-peptide ALA L 15 and KHB L 16 |
Chain | Residue |
F | PHE294 |
F | GLY295 |
F | GLU296 |
F | GLU325 |
L | GLY14 |
L | ARG17 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for Di-peptide KHB L 16 and ARG L 17 |
Chain | Residue |
F | PHE294 |
F | GLY295 |
F | GLU296 |
F | VAL324 |
F | GLU325 |
L | ALA15 |
L | HIS18 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | DNA_BIND: |
Chain | Residue | Details |
G | KHB16-LYS20 | |
H | KHB16-LYS20 | |
I | KHB16-LYS20 | |
J | KHB16-LYS20 | |
K | KHB16-LYS20 | |
L | KHB16-LYS20 | |
Chain | Residue | Details |
G | LYS12 | |
C | GLN228 | |
C | GLY319 | |
C | ASN344 | |
D | GLY145 | |
D | GLN228 | |
D | GLY319 | |
D | ASN344 | |
E | GLY145 | |
E | GLN228 | |
E | GLY319 | |
H | LYS12 | |
E | ASN344 | |
F | GLY145 | |
F | GLN228 | |
F | GLY319 | |
F | ASN344 | |
I | LYS12 | |
J | LYS12 | |
K | LYS12 | |
L | LYS12 | |
B | GLY319 | |
B | ASN344 | |
C | GLY145 | |
Chain | Residue | Details |
G | KHB16 | |
C | CYS259 | |
C | CYS280 | |
C | CYS283 | |
D | CYS256 | |
D | CYS259 | |
D | CYS280 | |
D | CYS283 | |
E | CYS256 | |
E | CYS259 | |
E | CYS280 | |
H | KHB16 | |
E | CYS283 | |
F | CYS256 | |
F | CYS259 | |
F | CYS280 | |
F | CYS283 | |
I | KHB16 | |
J | KHB16 | |
K | KHB16 | |
L | KHB16 | |
B | CYS280 | |
B | CYS283 | |
C | CYS256 | |
Chain | Residue | Details |
G | LYS20 | |
H | LYS20 | |
I | LYS20 | |
J | LYS20 | |
K | LYS20 | |
L | LYS20 | |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
Chain | Residue | Details |
G | LYS12 | |
H | LYS12 | |
I | LYS12 | |
J | LYS12 | |
K | LYS12 | |
L | LYS12 | |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
K | LYS20 | |
L | LYS20 | |
G | LYS20 | |
H | LYS20 | |
I | LYS20 | |
J | LYS20 | |