Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5ZDQ

Crystal structure of cyanide-insensitive alternative oxidase from Trypanosoma brucei with COLLETOCHLORIN B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0008199	molecular_function	ferric iron binding
A	0009916	molecular_function	alternative oxidase activity
A	0010230	biological_process	alternative respiration
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0043229	cellular_component	intracellular organelle
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0008199	molecular_function	ferric iron binding
B	0009916	molecular_function	alternative oxidase activity
B	0010230	biological_process	alternative respiration
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0043229	cellular_component	intracellular organelle
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0008199	molecular_function	ferric iron binding
C	0009916	molecular_function	alternative oxidase activity
C	0010230	biological_process	alternative respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0043229	cellular_component	intracellular organelle
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0008199	molecular_function	ferric iron binding
D	0009916	molecular_function	alternative oxidase activity
D	0010230	biological_process	alternative respiration
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0043229	cellular_component	intracellular organelle
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue FE A 501

Chain	Residue
A	GLU123
A	GLU162
A	HIS165
A	GLU266
A	FE502
A	OH503

site_id	AC2
Number of Residues	6
Details	binding site for residue FE A 502

Chain	Residue
A	FE501
A	OH503
A	HOH633
A	GLU162
A	GLU213
A	GLU266

site_id	AC3
Number of Residues	8
Details	binding site for residue OH A 503

Chain	Residue
A	GLU123
A	ALA126
A	GLU162
A	GLU213
A	GLU266
A	FE501
A	FE502
A	RNB504

site_id	AC4
Number of Residues	11
Details	binding site for residue RNB A 504

Chain	Residue
A	VAL92
A	ARG96
A	ARG118
A	LEU122
A	GLU123
A	LEU212
A	GLU215
A	ALA216
A	THR219
A	OH503
A	HOH633

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 505

Chain	Residue
A	ARG173
A	PRO175
A	GLY176
A	LEU179
A	HOH627

site_id	AC6
Number of Residues	6
Details	binding site for residue FE B 501

Chain	Residue
B	GLU123
B	GLU162
B	HIS165
B	GLU266
B	FE502
B	OH503

site_id	AC7
Number of Residues	6
Details	binding site for residue FE B 502

Chain	Residue
B	GLU162
B	GLU213
B	GLU266
B	FE501
B	OH503
B	HOH614

site_id	AC8
Number of Residues	7
Details	binding site for residue OH B 503

Chain	Residue
B	GLU123
B	ALA126
B	GLU162
B	GLU266
B	FE501
B	FE502
B	RNB504

site_id	AC9
Number of Residues	7
Details	binding site for residue RNB B 504

Chain	Residue
B	ARG96
B	ARG118
B	LEU122
B	LEU212
B	GLU215
B	THR219
B	OH503

site_id	AD1
Number of Residues	6
Details	binding site for residue FE C 501

Chain	Residue
C	GLU123
C	GLU162
C	HIS165
C	GLU266
C	FE502
C	OH503

site_id	AD2
Number of Residues	6
Details	binding site for residue FE C 502

Chain	Residue
C	GLU162
C	GLU213
C	GLU266
C	FE501
C	OH503
C	HOH612

site_id	AD3
Number of Residues	7
Details	binding site for residue OH C 503

Chain	Residue
C	GLU123
C	ALA126
C	GLU162
C	GLU266
C	FE501
C	FE502
C	RNB504

site_id	AD4
Number of Residues	12
Details	binding site for residue RNB C 504

Chain	Residue
C	PHE99
C	ARG118
C	CYS119
C	LEU122
C	GLU123
C	LEU212
C	GLU215
C	ALA216
C	THR219
C	TYR220
C	OH503
C	HOH612

site_id	AD5
Number of Residues	6
Details	binding site for residue FE D 501

Chain	Residue
D	GLU123
D	GLU162
D	HIS165
D	GLU266
D	FE502
D	OH503

site_id	AD6
Number of Residues	6
Details	binding site for residue FE D 502

Chain	Residue
D	GLU162
D	GLU213
D	GLU266
D	FE501
D	OH503
D	HOH630

site_id	AD7
Number of Residues	7
Details	binding site for residue OH D 503

Chain	Residue
D	GLU123
D	ALA126
D	GLU162
D	GLU266
D	FE501
D	FE502
D	RNB504

site_id	AD8
Number of Residues	11
Details	binding site for residue RNB D 504

Chain	Residue
D	VAL92
D	ARG96
D	ARG118
D	LEU122
D	GLU123
D	LEU212
D	GLU215
D	ALA216
D	THR219
D	OH503
D	HOH630

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 D 505

Chain	Residue
D	SER117
D	ARG173
D	PRO175
D	GLY176
D	LEU179

site_id	AE1
Number of Residues	2
Details	binding site for residue GOL D 506

Chain	Residue
D	ASN286
D	HOH642

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	VAL115-MET135
A	VAL181-SER201
B	VAL115-MET135
B	VAL181-SER201
C	VAL115-MET135
C	VAL181-SER201
D	VAL115-MET135
D	VAL181-SER201

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:23487766, ECO:0007744\|PDB:3W54

Chain	Residue	Details
A	GLU123
B	GLU213
B	GLU266
B	HIS269
C	GLU123
C	GLU162
C	HIS165
C	GLU213
C	GLU266
C	HIS269
D	GLU123
A	GLU162
D	GLU162
D	HIS165
D	GLU213
D	GLU266
D	HIS269
A	HIS165
A	GLU213
A	GLU266
A	HIS269
B	GLU123
B	GLU162
B	HIS165

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)