Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004798 | molecular_function | dTMP kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004798 | molecular_function | dTMP kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ADP A 201 |
| Chain | Residue |
| A | LEU11 |
| A | LEU180 |
| A | GLU182 |
| A | CA206 |
| A | HOH305 |
| A | HOH320 |
| A | HOH326 |
| A | HOH333 |
| A | HOH347 |
| A | GLY13 |
| A | SER14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | THR18 |
| A | GLN54 |
| A | ALA178 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CA A 202 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 203 |
| Chain | Residue |
| A | GLN19 |
| A | LEU23 |
| A | ILE189 |
| A | HOH374 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 204 |
| Chain | Residue |
| A | GLU61 |
| A | ARG104 |
| A | GLU148 |
| A | HOH302 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 205 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 206 |
| Chain | Residue |
| A | THR17 |
| A | ADP201 |
| A | HOH305 |
| A | HOH320 |
| A | HOH330 |
| A | HOH366 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 207 |
| Chain | Residue |
| A | TYR62 |
| A | SER66 |
| A | ARG69 |
| A | LEU93 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 208 |
| Chain | Residue |
| A | GLU39 |
| A | PRO40 |
| A | PHE65 |
| A | ASP68 |
| A | ARG69 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 209 |
| Chain | Residue |
| A | THR7 |
| A | GLU9 |
| A | TYR92 |
| A | ASP94 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 210 |
| Chain | Residue |
| A | GLY10 |
| A | LEU11 |
| A | LEU130 |
| A | ASP131 |
| A | LEU132 |
| A | HOH332 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 211 |
| Chain | Residue |
| A | GLU169 |
| A | PRO170 |
| A | GLY171 |
| A | ARG172 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 212 |
| Chain | Residue |
| A | LEU176 |
| A | ASP177 |
| A | LEU180 |
| A | HOH392 |
| site_id | AD4 |
| Number of Residues | 15 |
| Details | binding site for residue TMP A 213 |
| Chain | Residue |
| A | ASP12 |
| A | GLU39 |
| A | PRO40 |
| A | ARG48 |
| A | PHE65 |
| A | ARG69 |
| A | ARG91 |
| A | SER95 |
| A | SER96 |
| A | TYR99 |
| A | GLN100 |
| A | HOH303 |
| A | HOH307 |
| A | HOH320 |
| A | HOH330 |
| site_id | AD5 |
| Number of Residues | 20 |
| Details | binding site for residue ADP B 201 |
| Chain | Residue |
| A | GLY105 |
| A | HOH324 |
| B | LEU11 |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| B | THR18 |
| B | LEU138 |
| B | LEU180 |
| B | PRO181 |
| B | GLU182 |
| B | CA202 |
| B | HOH304 |
| B | HOH315 |
| B | HOH332 |
| B | HOH341 |
| B | HOH345 |
| B | HOH351 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 202 |
| Chain | Residue |
| B | HOH332 |
| B | HOH341 |
| B | HOH355 |
| B | THR17 |
| B | ADP201 |
| B | HOH306 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 203 |
| Chain | Residue |
| B | TYR62 |
| B | SER66 |
| B | ARG69 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CA B 204 |
| Chain | Residue |
| B | GLU160 |
| B | ARG167 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 205 |
| Chain | Residue |
| A | ARG112 |
| B | PRO134 |
| B | ALA137 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 206 |
| Chain | Residue |
| B | ARG157 |
| B | HOH326 |
| B | HOH363 |
| B | HOH369 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 207 |
| Chain | Residue |
| B | PHE65 |
| B | ASP68 |
| B | ARG69 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 208 |
| Chain | Residue |
| B | PRO109 |
| B | ASP177 |
| B | HOH322 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue TMP B 209 |
| Chain | Residue |
| B | ASP12 |
| B | PRO40 |
| B | ARG48 |
| B | PHE65 |
| B | ARG69 |
| B | SER95 |
| B | SER96 |
| B | TYR99 |
| B | GLN100 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ |
| Chain | Residue | Details |
| A | ILE88-GLN100 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00165","evidenceCode":"ECO:0000255"}]} |
5ZB4
