5ZB4
Crystal structure of thymidylate kinase in complex with ADP and TMP from thermus thermophilus HB8
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0004798 | molecular_function | thymidylate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006233 | biological_process | dTDP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue ADP A 201 |
Chain | Residue |
A | LEU11 |
A | LEU180 |
A | GLU182 |
A | CA206 |
A | HOH305 |
A | HOH320 |
A | HOH326 |
A | HOH333 |
A | HOH347 |
A | GLY13 |
A | SER14 |
A | GLY15 |
A | LYS16 |
A | THR17 |
A | THR18 |
A | GLN54 |
A | ALA178 |
site_id | AC2 |
Number of Residues | 1 |
Details | binding site for residue CA A 202 |
Chain | Residue |
A | ARG187 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CA A 203 |
Chain | Residue |
A | GLN19 |
A | LEU23 |
A | ILE189 |
A | HOH374 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CA A 204 |
Chain | Residue |
A | GLU61 |
A | ARG104 |
A | GLU148 |
A | HOH302 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue CA A 205 |
Chain | Residue |
A | ARG22 |
A | SER49 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue CA A 206 |
Chain | Residue |
A | THR17 |
A | ADP201 |
A | HOH305 |
A | HOH320 |
A | HOH330 |
A | HOH366 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue CA A 207 |
Chain | Residue |
A | TYR62 |
A | SER66 |
A | ARG69 |
A | LEU93 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue CA A 208 |
Chain | Residue |
A | GLU39 |
A | PRO40 |
A | PHE65 |
A | ASP68 |
A | ARG69 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue CA A 209 |
Chain | Residue |
A | THR7 |
A | GLU9 |
A | TYR92 |
A | ASP94 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue CA A 210 |
Chain | Residue |
A | GLY10 |
A | LEU11 |
A | LEU130 |
A | ASP131 |
A | LEU132 |
A | HOH332 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue CL A 211 |
Chain | Residue |
A | GLU169 |
A | PRO170 |
A | GLY171 |
A | ARG172 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue CL A 212 |
Chain | Residue |
A | LEU176 |
A | ASP177 |
A | LEU180 |
A | HOH392 |
site_id | AD4 |
Number of Residues | 15 |
Details | binding site for residue TMP A 213 |
Chain | Residue |
A | ASP12 |
A | GLU39 |
A | PRO40 |
A | ARG48 |
A | PHE65 |
A | ARG69 |
A | ARG91 |
A | SER95 |
A | SER96 |
A | TYR99 |
A | GLN100 |
A | HOH303 |
A | HOH307 |
A | HOH320 |
A | HOH330 |
site_id | AD5 |
Number of Residues | 20 |
Details | binding site for residue ADP B 201 |
Chain | Residue |
A | GLY105 |
A | HOH324 |
B | LEU11 |
B | GLY13 |
B | SER14 |
B | GLY15 |
B | LYS16 |
B | THR17 |
B | THR18 |
B | LEU138 |
B | LEU180 |
B | PRO181 |
B | GLU182 |
B | CA202 |
B | HOH304 |
B | HOH315 |
B | HOH332 |
B | HOH341 |
B | HOH345 |
B | HOH351 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue CA B 202 |
Chain | Residue |
B | HOH332 |
B | HOH341 |
B | HOH355 |
B | THR17 |
B | ADP201 |
B | HOH306 |
site_id | AD7 |
Number of Residues | 3 |
Details | binding site for residue CA B 203 |
Chain | Residue |
B | TYR62 |
B | SER66 |
B | ARG69 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue CA B 204 |
Chain | Residue |
B | GLU160 |
B | ARG167 |
site_id | AD9 |
Number of Residues | 3 |
Details | binding site for residue CA B 205 |
Chain | Residue |
A | ARG112 |
B | PRO134 |
B | ALA137 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue CA B 206 |
Chain | Residue |
B | ARG157 |
B | HOH326 |
B | HOH363 |
B | HOH369 |
site_id | AE2 |
Number of Residues | 3 |
Details | binding site for residue CA B 207 |
Chain | Residue |
B | PHE65 |
B | ASP68 |
B | ARG69 |
site_id | AE3 |
Number of Residues | 3 |
Details | binding site for residue CL B 208 |
Chain | Residue |
B | PRO109 |
B | ASP177 |
B | HOH322 |
site_id | AE4 |
Number of Residues | 9 |
Details | binding site for residue TMP B 209 |
Chain | Residue |
B | ASP12 |
B | PRO40 |
B | ARG48 |
B | PHE65 |
B | ARG69 |
B | SER95 |
B | SER96 |
B | TYR99 |
B | GLN100 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ |
Chain | Residue | Details |
A | ILE88-GLN100 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165 |
Chain | Residue | Details |
A | GLY10 | |
B | GLY10 |