5ZAX

Crystal structure of thymidylate kinase in complex with ADP, TDP and TMP from thermus thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004798	molecular_function	dTMP kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
B	0000166	molecular_function	nucleotide binding
B	0004798	molecular_function	dTMP kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ADP A 201

Chain	Residue
A	LEU11
A	LEU180
A	GLU182
A	MG206
A	HOH301
A	HOH302
A	HOH313
A	GLY13
A	SER14
A	GLY15
A	LYS16
A	THR17
A	THR18
A	GLN54
A	ALA178

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	THR7
A	GLU9
A	TYR92
A	ASP94
A	THR127

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 203

Chain	Residue
A	TYR62
A	SER66
A	ARG69

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 204

Chain	Residue
A	GLU160
A	ALA164
A	HOH309
B	LEU52

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MG A 205

Chain	Residue
A	LEU165
A	ALA168
A	GLU169
A	HOH315

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG A 206

Chain	Residue
A	THR17
A	ADP201
A	HOH301
A	HOH307
A	HOH313

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 207

Chain	Residue
A	GLU169
A	GLY171
A	ARG172

---

site_id	AC8
Number of Residues	14
Details	binding site for residue TYD A 208

Chain	Residue
A	ASP12
A	ARG38
A	GLU39
A	ARG48
A	PHE65
A	ARG69
A	ARG91
A	SER95
A	SER96
A	TYR99
A	GLN100
A	HOH301
A	HOH307
A	HOH310

---

site_id	AC9
Number of Residues	11
Details	binding site for residue TMP B 201

Chain	Residue
B	ASP12
B	ARG38
B	GLU39
B	PRO40
B	ARG48
B	PHE65
B	ARG69
B	SER95
B	SER96
B	TYR99
B	GLN100

---

site_id	AD1
Number of Residues	3
Details	binding site for residue MG B 202

Chain	Residue
B	TYR62
B	SER66
B	ARG69

---

site_id	AD2
Number of Residues	2
Details	binding site for residue MG B 203

Chain	Residue
B	PHE65
B	ASP68

---

site_id	AD3
Number of Residues	3
Details	binding site for residue MG B 204

Chain	Residue
B	LEU165
B	ALA168
B	GLU169

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL B 205

Chain	Residue
B	PRO124

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CL B 206

Chain	Residue
B	LEU4
B	PHE5

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CL B 207

Chain	Residue
B	GLY13
B	GLY15
B	LYS16
B	HOH326

---

Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ

Chain	Residue	Details
A	ILE88-GLN100

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00165","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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