Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5ZAK

Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0003725molecular_functiondouble-stranded RNA binding
A0004386molecular_functionhelicase activity
A0004519molecular_functionendonuclease activity
A0004521molecular_functionRNA endonuclease activity
A0004525molecular_functionribonuclease III activity
A0004530molecular_functiondeoxyribonuclease I activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006309biological_processapoptotic DNA fragmentation
A0006396biological_processRNA processing
A0010586biological_processmiRNA metabolic process
A0010626biological_processnegative regulation of Schwann cell proliferation
A0010629biological_processnegative regulation of gene expression
A0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
A0014040biological_processpositive regulation of Schwann cell differentiation
A0016078biological_processtRNA decay
A0016442cellular_componentRISC complex
A0016787molecular_functionhydrolase activity
A0016891molecular_functionRNA endonuclease activity, producing 5'-phosphomonoesters
A0019904molecular_functionprotein domain specific binding
A0021675biological_processnerve development
A0030422biological_processsiRNA processing
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031054biological_processpre-miRNA processing
A0031643biological_processpositive regulation of myelination
A0032290biological_processperipheral nervous system myelin formation
A0032720biological_processnegative regulation of tumor necrosis factor production
A0035196biological_processmiRNA processing
A0035197molecular_functionsiRNA binding
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048812biological_processneuron projection morphogenesis
A0070062cellular_componentextracellular exosome
A0070578cellular_componentRISC-loading complex
A0070883molecular_functionpre-miRNA binding
A0070922biological_processRISC complex assembly
A0098795biological_processglobal gene silencing by mRNA cleavage
A0140640molecular_functioncatalytic activity, acting on a nucleic acid
B0003723molecular_functionRNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006417biological_processregulation of translation
B0006469biological_processnegative regulation of protein kinase activity
B0016442cellular_componentRISC complex
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0030422biological_processsiRNA processing
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0031054biological_processpre-miRNA processing
B0035196biological_processmiRNA processing
B0035197molecular_functionsiRNA binding
B0035198molecular_functionmiRNA binding
B0036002molecular_functionpre-mRNA binding
B0039532biological_processnegative regulation of cytoplasmic pattern recognition receptor signaling pathway
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045070biological_processpositive regulation of viral genome replication
B0046782biological_processregulation of viral transcription
B0048471cellular_componentperinuclear region of cytoplasm
B0050689biological_processnegative regulation of defense response to virus by host
B0070578cellular_componentRISC-loading complex
B0070883molecular_functionpre-miRNA binding
B0070920biological_processregulation of regulatory ncRNA processing
B0070921biological_processregulation of siRNA processing
B0070922biological_processRISC complex assembly
B0098795biological_processglobal gene silencing by mRNA cleavage
B0140311molecular_functionprotein sequestering activity
B1903798biological_processregulation of miRNA processing
Functional Information from PROSITE/UniProt
site_idPS00517
Number of Residues9
DetailsRNASE_3_1 Ribonuclease III family signature. QRLEFLGDA
ChainResidueDetails
AGLN1702-ALA1710

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER152

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLU1316
AASP1395
AGLU1398

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:17920623, ECO:0007744|PDB:2EB1
ChainResidueDetails
AGLU1705
AASP1810
AGLU1813

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Important for activity => ECO:0000250|UniProtKB:Q8R418
ChainResidueDetails
ALYS1806

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER413
ASER415

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER1016

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1160
ASER1460
ASER1470
ASER1868

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R418
ChainResidueDetails
ASER1468

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon