5Z96

Structure of the mouse TRPC4 ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue Y01 A 801

Chain	Residue
A	TYR315
A	ASN499
D	PHE521
D	LEU525
A	TRP321
A	PHE363
A	LEU374
A	PHE378
A	LEU381
A	LEU495
A	PHE496
A	ALA498

---

site_id	AC2
Number of Residues	15
Details	binding site for residue LPP A 802

Chain	Residue
A	LEU513
A	LEU520
A	TYR523
A	LEU527
A	GLN569
A	PHE572
A	TRP573
A	ILE575
D	PHE595
D	ALA598
D	THR599
D	THR603
D	VAL606
D	ILE607
D	VAL611

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NA A 803

Chain	Residue
A	GLU417
A	GLN420
A	ASN435
A	ASP438

---

site_id	AC4
Number of Residues	9
Details	binding site for residue Y01 B 801

Chain	Residue
A	PHE521
A	LEU525
B	TYR315
B	PHE363
B	LEU374
B	PHE378
B	LEU495
B	PHE496
B	ASN499

---

site_id	AC5
Number of Residues	14
Details	binding site for residue LPP B 802

Chain	Residue
A	PHE595
A	ALA598
A	THR599
A	THR603
A	VAL606
A	ILE607
A	VAL611
B	LEU513
B	LEU520
B	TYR523
B	GLN569
B	PHE572
B	TRP573
B	ILE575

---

site_id	AC6
Number of Residues	17
Details	binding site for residue LPP B 803

Chain	Residue
B	PHE595
B	ALA598
B	THR599
B	GLY602
B	THR603
B	VAL606
B	ILE607
B	VAL610
C	LEU513
C	LEU520
C	TYR523
C	LEU527
C	GLN569
C	PHE572
C	TRP573
C	ILE575
C	LEU613

---

site_id	AC7
Number of Residues	4
Details	binding site for residue NA B 804

Chain	Residue
B	GLU417
B	GLN420
B	ASN435
B	ASP438

---

site_id	AC8
Number of Residues	7
Details	binding site for residue Y01 C 801

Chain	Residue
B	PHE521
C	TYR315
C	TRP321
C	PHE363
C	LEU374
C	LEU495
C	PHE496

---

site_id	AC9
Number of Residues	4
Details	binding site for residue NA C 802

Chain	Residue
C	GLU417
C	GLN420
C	ASN435
C	ASP438

---

site_id	AD1
Number of Residues	10
Details	binding site for residue Y01 D 801

Chain	Residue
C	PHE521
C	LEU525
D	TYR315
D	TRP321
D	PHE363
D	LEU374
D	PHE378
D	LEU495
D	PHE496
D	ASN499

---

site_id	AD2
Number of Residues	15
Details	binding site for residue LPP D 802

Chain	Residue
C	THR603
C	VAL606
C	ILE607
C	VAL611
D	LEU513
D	LEU520
D	TYR523
D	LEU527
D	GLN569
D	PHE572
D	TRP573
D	ILE575
C	PHE595
C	ALA598
C	THR599

---

site_id	AD3
Number of Residues	4
Details	binding site for residue NA D 803

Chain	Residue
D	GLU417
D	GLN420
D	ASN435
D	ASP438

---

Functional Information from PROSITE/UniProt

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG

Chain	Residue	Details
A	LEU492-GLY503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Intramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	108
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	256
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	124
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	88
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	88
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	96
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	148
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UBN4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---