5Z6U
Crystal structure of D-xylose reductase from Scheffersomyces stipitis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019388 | biological_process | galactose catabolic process |
| A | 0019568 | biological_process | arabinose catabolic process |
| A | 0032866 | molecular_function | D-xylose reductase (NADPH) activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042732 | biological_process | D-xylose metabolic process |
| A | 0042843 | biological_process | D-xylose catabolic process |
| A | 0071470 | biological_process | cellular response to osmotic stress |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019388 | biological_process | galactose catabolic process |
| B | 0019568 | biological_process | arabinose catabolic process |
| B | 0032866 | molecular_function | D-xylose reductase (NADPH) activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0042732 | biological_process | D-xylose metabolic process |
| B | 0042843 | biological_process | D-xylose catabolic process |
| B | 0071470 | biological_process | cellular response to osmotic stress |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | TYR48 |
| A | LYS77 |
| A | HIS110 |
| A | ASN166 |
| A | GLN187 |
| A | TYR213 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| B | ASN166 |
| B | GLN187 |
| B | TYR213 |
| B | TYR48 |
| B | LYS77 |
| B | HIS110 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LeklvkagkIRSIGVSNF |
| Chain | Residue | Details |
| A | LEU150-PHE167 |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSNTvpRLlENkDV |
| Chain | Residue | Details |
| A | ILE268-VAL283 |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRLFDGAedyanEklVG |
| Chain | Residue | Details |
| A | GLY38-GLY55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
