Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5Z5O

Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000423	biological_process	mitophagy
A	0001968	molecular_function	fibronectin binding
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005518	molecular_function	collagen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0006508	biological_process	proteolysis
A	0006590	biological_process	thyroid hormone generation
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0009897	cellular_component	external side of plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030574	biological_process	collagen catabolic process
A	0036021	cellular_component	endolysosome lumen
A	0043202	cellular_component	lysosomal lumen
A	0043394	molecular_function	proteoglycan binding
A	0051603	biological_process	obsolete proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 401

Chain	Residue
A	LYS20
A	ASP65
A	GLU70
A	LYS74
A	GLN120
A	HOH508
A	HOH604

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 402

Chain	Residue
A	THR113
A	PRO114
A	TYR292
A	HOH583
A	ARG107
A	VAL112

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 403

Chain	Residue
A	ALA185
A	MET196
A	TYR197

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 404

Chain	Residue
A	SER245
A	ASN286
A	GLY288
A	ASN289
A	HOH530
A	HOH540
A	HOH569
A	HOH572
A	HOH576

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 405

Chain	Residue
A	ASN38
A	SEB68

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 406

Chain	Residue
A	PRO114
A	LYS116
A	ASN146
A	EDO411
A	EDO418
A	HOH506

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 407

Chain	Residue
A	SER85
A	ARG207
A	EDO420
A	HOH634

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 408

Chain	Residue
A	ILE44
A	GLU48

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 409

Chain	Residue
A	ILE180

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 410

Chain	Residue
A	VAL72
A	THR76
A	GLY77
A	LEU78
A	ASN260

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 411

Chain	Residue
A	LYS116
A	ASN117
A	GOL406
A	HOH542
A	HOH586

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 412

Chain	Residue
A	LYS40
A	SER43
A	ILE44
B	GLU4
B	LYS40
B	EDO103

site_id	AD4
Number of Residues	1
Details	binding site for residue EDO A 413

Chain	Residue
A	THR9

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO A 414

Chain	Residue
A	VAL53
A	HIS54
A	ASP251
A	GLU252
A	HOH547
A	HOH568

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 415

Chain	Residue
A	VAL104
A	ASP105
A	LYS109

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO A 416

Chain	Residue
A	TYR22
A	ASN23
A	ASP27
A	ARG31

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO A 417

Chain	Residue
A	ASP89
A	CYS206
A	ARG207
A	ARG210

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 418

Chain	Residue
A	LEU144
A	GOL406
A	HOH528
A	HOH603

site_id	AE1
Number of Residues	5
Details	binding site for residue EDO A 419

Chain	Residue
A	TYR106
A	LYS139
A	ALA225
A	ARG226
A	VAL227

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO A 420

Chain	Residue
A	SER85
A	TYR209
A	GLU211
A	GOL407

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 A 421

Chain	Residue
A	TYR22
A	ASN24
A	LYS25
A	GLU28
A	HOH504

site_id	AE4
Number of Residues	6
Details	binding site for residue PEG A 422

Chain	Residue
A	ASP105
A	LYS108
A	ILE270
A	HIS276
A	HOH619
A	HOH640

site_id	AE5
Number of Residues	6
Details	binding site for residue PEG A 423

Chain	Residue
A	LYS218
A	LYS221
A	LYS275
A	ARG297
A	ASN298
A	ASP102

site_id	AE6
Number of Residues	6
Details	binding site for residue PEG A 424

Chain	Residue
A	HIS62
A	ASN117
A	GLN120
A	HOH508
A	HOH531
A	HOH636

site_id	AE7
Number of Residues	2
Details	binding site for residue PEG A 425

Chain	Residue
A	SER194
A	CYS195

site_id	AE8
Number of Residues	3
Details	binding site for residue PEG A 426

Chain	Residue
A	ASN24
A	LYS25
A	VAL26

site_id	AE9
Number of Residues	3
Details	binding site for residue PEG A 427

Chain	Residue
A	THR67
A	GLU69
A	GLN73

site_id	AF1
Number of Residues	2
Details	binding site for residue CL A 428

Chain	Residue
A	LYS143
A	LEU144

site_id	AF2
Number of Residues	3
Details	binding site for residue NA A 429

Chain	Residue
A	GLN150
A	ASP154
A	GLU193

site_id	AF3
Number of Residues	5
Details	binding site for residue GOL B 101

Chain	Residue
B	LYS20
B	ARG31
B	ASP65
B	MET66
B	EDO104

site_id	AF4
Number of Residues	1
Details	binding site for residue EDO B 102

Chain	Residue
B	GLU28

site_id	AF5
Number of Residues	5
Details	binding site for residue EDO B 103

Chain	Residue
A	EDO412
B	GLU4
B	LEU7
B	GLU36
B	LYS40

site_id	AF6
Number of Residues	4
Details	binding site for residue EDO B 104

Chain	Residue
B	ASN23
B	ASP27
B	ARG31
B	GOL101

site_id	AF7
Number of Residues	4
Details	binding site for residue SO4 B 105

Chain	Residue
B	HIS54
B	TYR56
B	MPD112
B	HOH209

site_id	AF8
Number of Residues	4
Details	binding site for residue SO4 B 106

Chain	Residue
A	HOH518
B	HIS18
B	ASN61
B	HIS62

site_id	AF9
Number of Residues	1
Details	binding site for residue SO4 B 107

Chain	Residue
B	THR9

site_id	AG1
Number of Residues	1
Details	binding site for residue SO4 B 108

Chain	Residue
B	GLU12

site_id	AG2
Number of Residues	6
Details	binding site for residue PEG B 109

Chain	Residue
A	GLU57
B	GLU57
B	LEU58
B	HOH201
B	HOH210
B	HOH217

site_id	AG3
Number of Residues	1
Details	binding site for residue MPD B 110

Chain	Residue
B	THR55

site_id	AG4
Number of Residues	1
Details	binding site for residue MPD B 111

Chain	Residue
B	LYS25

site_id	AG5
Number of Residues	2
Details	binding site for residue MPD B 112

Chain	Residue
B	HIS54
B	SO4105

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG

Chain	Residue	Details
A	LEU259-GLY269

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM

Chain	Residue	Details
A	HIS276-MET295

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)