5Z5O
Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000423 | biological_process | mitophagy |
| A | 0001957 | biological_process | intramembranous ossification |
| A | 0001968 | molecular_function | fibronectin binding |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006590 | biological_process | thyroid hormone generation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006955 | biological_process | immune response |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008656 | molecular_function | cysteine-type endopeptidase activator activity involved in apoptotic process |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0014070 | biological_process | response to organic cyclic compound |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030574 | biological_process | collagen catabolic process |
| A | 0032868 | biological_process | response to insulin |
| A | 0034224 | biological_process | cellular response to zinc ion starvation |
| A | 0036021 | cellular_component | endolysosome lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0043394 | molecular_function | proteoglycan binding |
| A | 0045453 | biological_process | bone resorption |
| A | 0045471 | biological_process | response to ethanol |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| A | 0061037 | biological_process | negative regulation of cartilage development |
| A | 0071356 | biological_process | cellular response to tumor necrosis factor |
| A | 0071560 | biological_process | cellular response to transforming growth factor beta stimulus |
| A | 1903131 | biological_process | mononuclear cell differentiation |
| A | 2001235 | biological_process | positive regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | LYS20 |
| A | ASP65 |
| A | GLU70 |
| A | LYS74 |
| A | GLN120 |
| A | HOH508 |
| A | HOH604 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | THR113 |
| A | PRO114 |
| A | TYR292 |
| A | HOH583 |
| A | ARG107 |
| A | VAL112 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ALA185 |
| A | MET196 |
| A | TYR197 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | SER245 |
| A | ASN286 |
| A | GLY288 |
| A | ASN289 |
| A | HOH530 |
| A | HOH540 |
| A | HOH569 |
| A | HOH572 |
| A | HOH576 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ASN38 |
| A | SEB68 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | PRO114 |
| A | LYS116 |
| A | ASN146 |
| A | EDO411 |
| A | EDO418 |
| A | HOH506 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | SER85 |
| A | ARG207 |
| A | EDO420 |
| A | HOH634 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | ILE44 |
| A | GLU48 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | ILE180 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | VAL72 |
| A | THR76 |
| A | GLY77 |
| A | LEU78 |
| A | ASN260 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | LYS116 |
| A | ASN117 |
| A | GOL406 |
| A | HOH542 |
| A | HOH586 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | LYS40 |
| A | SER43 |
| A | ILE44 |
| B | GLU4 |
| B | LYS40 |
| B | EDO103 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | THR9 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | VAL53 |
| A | HIS54 |
| A | ASP251 |
| A | GLU252 |
| A | HOH547 |
| A | HOH568 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | VAL104 |
| A | ASP105 |
| A | LYS109 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | TYR22 |
| A | ASN23 |
| A | ASP27 |
| A | ARG31 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | ASP89 |
| A | CYS206 |
| A | ARG207 |
| A | ARG210 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | LEU144 |
| A | GOL406 |
| A | HOH528 |
| A | HOH603 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 419 |
| Chain | Residue |
| A | TYR106 |
| A | LYS139 |
| A | ALA225 |
| A | ARG226 |
| A | VAL227 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 420 |
| Chain | Residue |
| A | SER85 |
| A | TYR209 |
| A | GLU211 |
| A | GOL407 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 421 |
| Chain | Residue |
| A | TYR22 |
| A | ASN24 |
| A | LYS25 |
| A | GLU28 |
| A | HOH504 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 422 |
| Chain | Residue |
| A | ASP105 |
| A | LYS108 |
| A | ILE270 |
| A | HIS276 |
| A | HOH619 |
| A | HOH640 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 423 |
| Chain | Residue |
| A | LYS218 |
| A | LYS221 |
| A | LYS275 |
| A | ARG297 |
| A | ASN298 |
| A | ASP102 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 424 |
| Chain | Residue |
| A | HIS62 |
| A | ASN117 |
| A | GLN120 |
| A | HOH508 |
| A | HOH531 |
| A | HOH636 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 425 |
| Chain | Residue |
| A | SER194 |
| A | CYS195 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 426 |
| Chain | Residue |
| A | ASN24 |
| A | LYS25 |
| A | VAL26 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 427 |
| Chain | Residue |
| A | THR67 |
| A | GLU69 |
| A | GLN73 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 428 |
| Chain | Residue |
| A | LYS143 |
| A | LEU144 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 429 |
| Chain | Residue |
| A | GLN150 |
| A | ASP154 |
| A | GLU193 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 101 |
| Chain | Residue |
| B | LYS20 |
| B | ARG31 |
| B | ASP65 |
| B | MET66 |
| B | EDO104 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 102 |
| Chain | Residue |
| B | GLU28 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 103 |
| Chain | Residue |
| A | EDO412 |
| B | GLU4 |
| B | LEU7 |
| B | GLU36 |
| B | LYS40 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 104 |
| Chain | Residue |
| B | ASN23 |
| B | ASP27 |
| B | ARG31 |
| B | GOL101 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 105 |
| Chain | Residue |
| B | HIS54 |
| B | TYR56 |
| B | MPD112 |
| B | HOH209 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 106 |
| Chain | Residue |
| A | HOH518 |
| B | HIS18 |
| B | ASN61 |
| B | HIS62 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 107 |
| Chain | Residue |
| B | THR9 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 108 |
| Chain | Residue |
| B | GLU12 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 109 |
| Chain | Residue |
| A | GLU57 |
| B | GLU57 |
| B | LEU58 |
| B | HOH201 |
| B | HOH210 |
| B | HOH217 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue MPD B 110 |
| Chain | Residue |
| B | THR55 |
| site_id | AG4 |
| Number of Residues | 1 |
| Details | binding site for residue MPD B 111 |
| Chain | Residue |
| B | LYS25 |
| site_id | AG5 |
| Number of Residues | 2 |
| Details | binding site for residue MPD B 112 |
| Chain | Residue |
| B | HIS54 |
| B | SO4105 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG |
| Chain | Residue | Details |
| A | LEU259-GLY269 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM |
| Chain | Residue | Details |
| A | HIS276-MET295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | SER124 | |
| A | HIS261 | |
| A | ASN281 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN88 |
