5Z1S

Crystal Structure Analysis of the BRD4(1)

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue EFM A 201

Chain	Residue
A	TRP81
A	HOH350
A	VAL87
A	LYS99
A	ILE100
A	ASN140
A	ILE146
A	MET149
A	HOH307
A	HOH325

---

site_id	AC2
Number of Residues	7
Details	binding site for residue NO3 A 202

Chain	Residue
A	LYS55
A	PRO56
A	LYS57
A	TYR98
A	LYS99
A	LYS102
A	ASP145

---

site_id	AC3
Number of Residues	9
Details	binding site for residue NO3 A 203

Chain	Residue
A	HIS34
A	HIS35
A	HIS36
A	HIS37
A	LEU38
A	VAL39
A	GLN123
A	ILE126
A	ASN130

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 204

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 205

Chain	Residue
A	GLN78
A	HOH301
A	HOH330
A	HOH334

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 206

Chain	Residue
A	PRO86
A	HOH322

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL A 207

Chain	Residue
A	PRO46
A	PRO47
A	PRO48
A	ARG58
A	TRP120
A	ASN121
A	HOH315
A	HOH320

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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