Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5Z19

The crystal structure of Ruminococcus gnavus beta-glucuronidase in complex with uronic isofagomine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004565	molecular_function	beta-galactosidase activity
A	0004566	molecular_function	beta-glucuronidase activity
A	0005102	molecular_function	signaling receptor binding
A	0005615	cellular_component	extracellular space
A	0005975	biological_process	carbohydrate metabolic process
A	0008152	biological_process	metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019391	biological_process	glucuronoside catabolic process
A	0030246	molecular_function	carbohydrate binding
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004565	molecular_function	beta-galactosidase activity
B	0004566	molecular_function	beta-glucuronidase activity
B	0005102	molecular_function	signaling receptor binding
B	0005615	cellular_component	extracellular space
B	0005975	biological_process	carbohydrate metabolic process
B	0008152	biological_process	metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0019391	biological_process	glucuronoside catabolic process
B	0030246	molecular_function	carbohydrate binding
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0004565	molecular_function	beta-galactosidase activity
C	0004566	molecular_function	beta-glucuronidase activity
C	0005102	molecular_function	signaling receptor binding
C	0005615	cellular_component	extracellular space
C	0005975	biological_process	carbohydrate metabolic process
C	0008152	biological_process	metabolic process
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0019391	biological_process	glucuronoside catabolic process
C	0030246	molecular_function	carbohydrate binding
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0004565	molecular_function	beta-galactosidase activity
D	0004566	molecular_function	beta-glucuronidase activity
D	0005102	molecular_function	signaling receptor binding
D	0005615	cellular_component	extracellular space
D	0005975	biological_process	carbohydrate metabolic process
D	0008152	biological_process	metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0019391	biological_process	glucuronoside catabolic process
D	0030246	molecular_function	carbohydrate binding
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0004565	molecular_function	beta-galactosidase activity
E	0004566	molecular_function	beta-glucuronidase activity
E	0005102	molecular_function	signaling receptor binding
E	0005615	cellular_component	extracellular space
E	0005975	biological_process	carbohydrate metabolic process
E	0008152	biological_process	metabolic process
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0019391	biological_process	glucuronoside catabolic process
E	0030246	molecular_function	carbohydrate binding
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0004565	molecular_function	beta-galactosidase activity
F	0004566	molecular_function	beta-glucuronidase activity
F	0005102	molecular_function	signaling receptor binding
F	0005615	cellular_component	extracellular space
F	0005975	biological_process	carbohydrate metabolic process
F	0008152	biological_process	metabolic process
F	0016787	molecular_function	hydrolase activity
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0019391	biological_process	glucuronoside catabolic process
F	0030246	molecular_function	carbohydrate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue SJ5 A 701

Chain	Residue
A	ASP167
A	ASN574
A	LYS576
A	HOH814
A	HOH817
A	HIS335
A	PHE369
A	GLU418
A	TYR474
A	TYR478
A	GLU512
A	TRP557
A	ARG570

site_id	AC2
Number of Residues	12
Details	binding site for residue SJ5 B 701

Chain	Residue
B	ASP167
B	HIS335
B	PHE369
B	GLU418
B	TYR474
B	TYR478
B	GLU512
B	TRP557
B	PHE562
B	ARG570
B	ASN574
B	LYS576

site_id	AC3
Number of Residues	12
Details	binding site for residue SJ5 C 701

Chain	Residue
C	ASP167
C	HIS335
C	PHE369
C	GLU418
C	TYR474
C	TYR478
C	GLU512
C	TRP557
C	ARG570
C	ASN574
C	LYS576
C	HOH815

site_id	AC4
Number of Residues	12
Details	binding site for residue SJ5 D 701

Chain	Residue
D	ASP167
D	HIS335
D	PHE369
D	GLU418
D	TYR474
D	TYR478
D	GLU512
D	TRP557
D	ARG570
D	ASN574
D	LYS576
D	HOH813

site_id	AC5
Number of Residues	13
Details	binding site for residue SJ5 E 701

Chain	Residue
E	ASP167
E	HIS335
E	PHE369
E	GLU418
E	TYR474
E	TYR478
E	GLU512
E	TRP557
E	ARG570
E	ASN574
E	LYS576
E	HOH806
E	HOH810

site_id	AC6
Number of Residues	12
Details	binding site for residue SJ5 F 701

Chain	Residue
F	ASP167
F	HIS335
F	PHE369
F	GLU418
F	TYR474
F	TYR478
F	GLU512
F	TRP557
F	ARG570
F	ASN574
F	LYS576
F	HOH813

Functional Information from PROSITE/UniProt

site_id	PS00719
Number of Residues	26
Details	GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NcFRTSHYPyaeeWYqfaDeeGFLII

Chain	Residue	Details
A	ASN329-ILE354

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)