5YXL

A ligand M binding to FXR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0032052	molecular_function	bile acid binding
C	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue NIW A 301

Chain	Residue
A	PHE41
A	HIS204
A	MET207
A	VAL213
A	TRP226
A	THR45
A	HIS51
A	MET85
A	PHE86
A	SER89
A	ILE114
A	TYR118
A	MET122

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site_id	AC2
Number of Residues	15
Details	binding site for residue NIW C 301

Chain	Residue
C	PHE41
C	LEU44
C	THR45
C	ALA48
C	HIS51
C	MET85
C	PHE86
C	ILE114
C	TYR118
C	MET122
C	PHE200
C	HIS203
C	HIS204
C	MET207
C	TRP226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG88
A	TYR118
A	TYR126
A	HIS204
C	ARG88
C	TYR118
C	TYR126
C	HIS204

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR199
C	THR199

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LYS32
C	LYS32

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