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5YWD

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)

Functional Information from GO Data
ChainGOidnamespacecontents
B0005267molecular_functionpotassium channel activity
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006813biological_processpotassium ion transport
B0008281molecular_functionsulfonylurea receptor activity
B0008282cellular_componentinward rectifying potassium channel
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
B0032991cellular_componentprotein-containing complex
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0043531molecular_functionADP binding
B0044325molecular_functiontransmembrane transporter binding
B0046676biological_processnegative regulation of insulin secretion
B0050905biological_processneuromuscular process
B0055085biological_processtransmembrane transport
B0061535biological_processglutamate secretion, neurotransmission
B0071805biological_processpotassium ion transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B0098662biological_processinorganic cation transmembrane transport
B0098793cellular_componentpresynapse
B0140359molecular_functionABC-type transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue ADP B 2501
ChainResidue
BTRP688
BMG2503
BGLY716
BGLY718
BLYS719
BSER720
BSER721
BGLN775
BGLU1480
BSER1483

site_idAC2
Number of Residues10
Detailsbinding site for residue ADP B 2502
ChainResidue
BARG1111
BGLU1114
BTYR1354
BGLY1382
BSER1383
BGLY1384
BLYS1385
BSER1386
BSER1387
BMG2504

site_idAC3
Number of Residues3
Detailsbinding site for residue MG B 2503
ChainResidue
BSER720
BGLN775
BADP2501

site_idAC4
Number of Residues3
Detailsbinding site for residue MG B 2504
ChainResidue
BSER1386
BGLN1427
BADP2502

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL
ChainResidueDetails
BLEU830-LEU844
BPHE1482-PHE1496

219869

PDB entries from 2024-05-15

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