Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5YW9

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0001666	biological_process	response to hypoxia
A	0001669	cellular_component	acrosomal vesicle
A	0002931	biological_process	response to ischemia
A	0003229	biological_process	ventricular cardiac muscle tissue development
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006813	biological_process	potassium ion transport
A	0006915	biological_process	apoptotic process
A	0006950	biological_process	response to stress
A	0008282	cellular_component	inward rectifying potassium channel
A	0008340	biological_process	determination of adult lifespan
A	0009410	biological_process	response to xenobiotic stimulus
A	0014704	cellular_component	intercalated disc
A	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
A	0016020	cellular_component	membrane
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0030315	cellular_component	T-tubule
A	0030506	molecular_function	ankyrin binding
A	0030673	cellular_component	axolemma
A	0030955	molecular_function	potassium ion binding
A	0031072	molecular_function	heat shock protein binding
A	0031669	biological_process	cellular response to nutrient levels
A	0032355	biological_process	response to estradiol
A	0033198	biological_process	response to ATP
A	0033574	biological_process	response to testosterone
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042383	cellular_component	sarcolemma
A	0042391	biological_process	regulation of membrane potential
A	0042734	cellular_component	presynaptic membrane
A	0043025	cellular_component	neuronal cell body
A	0044325	molecular_function	transmembrane transporter binding
A	0046676	biological_process	negative regulation of insulin secretion
A	0050796	biological_process	regulation of insulin secretion
A	0050877	biological_process	nervous system process
A	0061762	biological_process	CAMKK-AMPK signaling cascade
A	0070852	cellular_component	cell body fiber
A	0071316	biological_process	cellular response to nicotine
A	0071333	biological_process	cellular response to glucose stimulus
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071805	biological_process	potassium ion transmembrane transport
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098978	cellular_component	glutamatergic synapse
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1904638	biological_process	response to resveratrol
A	1990573	biological_process	potassium ion import across plasma membrane
B	0001508	biological_process	action potential
B	0005267	molecular_function	potassium channel activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006813	biological_process	potassium ion transport
B	0008281	molecular_function	sulfonylurea receptor activity
B	0008282	cellular_component	inward rectifying potassium channel
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0031669	biological_process	cellular response to nutrient levels
B	0032991	cellular_component	protein-containing complex
B	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
B	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
B	0043531	molecular_function	ADP binding
B	0044325	molecular_function	transmembrane transporter binding
B	0046676	biological_process	negative regulation of insulin secretion
B	0050905	biological_process	neuromuscular process
B	0055085	biological_process	transmembrane transport
B	0061535	biological_process	glutamate secretion, neurotransmission
B	0071805	biological_process	potassium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0098662	biological_process	inorganic cation transmembrane transport
B	0098793	cellular_component	presynapse
B	0140359	molecular_function	ABC-type transporter activity
C	0001508	biological_process	action potential
C	0001666	biological_process	response to hypoxia
C	0001669	cellular_component	acrosomal vesicle
C	0002931	biological_process	response to ischemia
C	0003229	biological_process	ventricular cardiac muscle tissue development
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006813	biological_process	potassium ion transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0008282	cellular_component	inward rectifying potassium channel
C	0008340	biological_process	determination of adult lifespan
C	0009410	biological_process	response to xenobiotic stimulus
C	0014704	cellular_component	intercalated disc
C	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
C	0016020	cellular_component	membrane
C	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
C	0030315	cellular_component	T-tubule
C	0030506	molecular_function	ankyrin binding
C	0030673	cellular_component	axolemma
C	0030955	molecular_function	potassium ion binding
C	0031072	molecular_function	heat shock protein binding
C	0031669	biological_process	cellular response to nutrient levels
C	0032355	biological_process	response to estradiol
C	0033198	biological_process	response to ATP
C	0033574	biological_process	response to testosterone
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0042383	cellular_component	sarcolemma
C	0042391	biological_process	regulation of membrane potential
C	0042734	cellular_component	presynaptic membrane
C	0043025	cellular_component	neuronal cell body
C	0044325	molecular_function	transmembrane transporter binding
C	0046676	biological_process	negative regulation of insulin secretion
C	0050796	biological_process	regulation of insulin secretion
C	0050877	biological_process	nervous system process
C	0061762	biological_process	CAMKK-AMPK signaling cascade
C	0070852	cellular_component	cell body fiber
C	0071316	biological_process	cellular response to nicotine
C	0071333	biological_process	cellular response to glucose stimulus
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0071805	biological_process	potassium ion transmembrane transport
C	0098662	biological_process	inorganic cation transmembrane transport
C	0098978	cellular_component	glutamatergic synapse
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	1903078	biological_process	positive regulation of protein localization to plasma membrane
C	1904638	biological_process	response to resveratrol
C	1990573	biological_process	potassium ion import across plasma membrane
D	0001508	biological_process	action potential
D	0005267	molecular_function	potassium channel activity
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006813	biological_process	potassium ion transport
D	0008281	molecular_function	sulfonylurea receptor activity
D	0008282	cellular_component	inward rectifying potassium channel
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
D	0031669	biological_process	cellular response to nutrient levels
D	0032991	cellular_component	protein-containing complex
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
D	0043531	molecular_function	ADP binding
D	0044325	molecular_function	transmembrane transporter binding
D	0046676	biological_process	negative regulation of insulin secretion
D	0050905	biological_process	neuromuscular process
D	0055085	biological_process	transmembrane transport
D	0061535	biological_process	glutamate secretion, neurotransmission
D	0071805	biological_process	potassium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0098662	biological_process	inorganic cation transmembrane transport
D	0098793	cellular_component	presynapse
D	0140359	molecular_function	ABC-type transporter activity
E	0001508	biological_process	action potential
E	0001666	biological_process	response to hypoxia
E	0001669	cellular_component	acrosomal vesicle
E	0002931	biological_process	response to ischemia
E	0003229	biological_process	ventricular cardiac muscle tissue development
E	0005242	molecular_function	inward rectifier potassium channel activity
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005886	cellular_component	plasma membrane
E	0006006	biological_process	glucose metabolic process
E	0006813	biological_process	potassium ion transport
E	0006915	biological_process	apoptotic process
E	0006950	biological_process	response to stress
E	0008282	cellular_component	inward rectifying potassium channel
E	0008340	biological_process	determination of adult lifespan
E	0009410	biological_process	response to xenobiotic stimulus
E	0014704	cellular_component	intercalated disc
E	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
E	0016020	cellular_component	membrane
E	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
E	0030315	cellular_component	T-tubule
E	0030506	molecular_function	ankyrin binding
E	0030673	cellular_component	axolemma
E	0030955	molecular_function	potassium ion binding
E	0031072	molecular_function	heat shock protein binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032355	biological_process	response to estradiol
E	0033198	biological_process	response to ATP
E	0033574	biological_process	response to testosterone
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0042383	cellular_component	sarcolemma
E	0042391	biological_process	regulation of membrane potential
E	0042734	cellular_component	presynaptic membrane
E	0043025	cellular_component	neuronal cell body
E	0044325	molecular_function	transmembrane transporter binding
E	0046676	biological_process	negative regulation of insulin secretion
E	0050796	biological_process	regulation of insulin secretion
E	0050877	biological_process	nervous system process
E	0061762	biological_process	CAMKK-AMPK signaling cascade
E	0070852	cellular_component	cell body fiber
E	0071316	biological_process	cellular response to nicotine
E	0071333	biological_process	cellular response to glucose stimulus
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0071805	biological_process	potassium ion transmembrane transport
E	0098662	biological_process	inorganic cation transmembrane transport
E	0098978	cellular_component	glutamatergic synapse
E	0099505	biological_process	regulation of presynaptic membrane potential
E	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E	1903078	biological_process	positive regulation of protein localization to plasma membrane
E	1904638	biological_process	response to resveratrol
E	1990573	biological_process	potassium ion import across plasma membrane
F	0001508	biological_process	action potential
F	0005267	molecular_function	potassium channel activity
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006813	biological_process	potassium ion transport
F	0008281	molecular_function	sulfonylurea receptor activity
F	0008282	cellular_component	inward rectifying potassium channel
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
F	0031669	biological_process	cellular response to nutrient levels
F	0032991	cellular_component	protein-containing complex
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
F	0043531	molecular_function	ADP binding
F	0044325	molecular_function	transmembrane transporter binding
F	0046676	biological_process	negative regulation of insulin secretion
F	0050905	biological_process	neuromuscular process
F	0055085	biological_process	transmembrane transport
F	0061535	biological_process	glutamate secretion, neurotransmission
F	0071805	biological_process	potassium ion transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
F	0098662	biological_process	inorganic cation transmembrane transport
F	0098793	cellular_component	presynapse
F	0140359	molecular_function	ABC-type transporter activity
G	0001508	biological_process	action potential
G	0001666	biological_process	response to hypoxia
G	0001669	cellular_component	acrosomal vesicle
G	0002931	biological_process	response to ischemia
G	0003229	biological_process	ventricular cardiac muscle tissue development
G	0005242	molecular_function	inward rectifier potassium channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005635	cellular_component	nuclear envelope
G	0005737	cellular_component	cytoplasm
G	0005768	cellular_component	endosome
G	0005886	cellular_component	plasma membrane
G	0006006	biological_process	glucose metabolic process
G	0006813	biological_process	potassium ion transport
G	0006915	biological_process	apoptotic process
G	0006950	biological_process	response to stress
G	0008282	cellular_component	inward rectifying potassium channel
G	0008340	biological_process	determination of adult lifespan
G	0009410	biological_process	response to xenobiotic stimulus
G	0014704	cellular_component	intercalated disc
G	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
G	0016020	cellular_component	membrane
G	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
G	0030315	cellular_component	T-tubule
G	0030506	molecular_function	ankyrin binding
G	0030673	cellular_component	axolemma
G	0030955	molecular_function	potassium ion binding
G	0031072	molecular_function	heat shock protein binding
G	0031669	biological_process	cellular response to nutrient levels
G	0032355	biological_process	response to estradiol
G	0033198	biological_process	response to ATP
G	0033574	biological_process	response to testosterone
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0042383	cellular_component	sarcolemma
G	0042391	biological_process	regulation of membrane potential
G	0042734	cellular_component	presynaptic membrane
G	0043025	cellular_component	neuronal cell body
G	0044325	molecular_function	transmembrane transporter binding
G	0046676	biological_process	negative regulation of insulin secretion
G	0050796	biological_process	regulation of insulin secretion
G	0050877	biological_process	nervous system process
G	0061762	biological_process	CAMKK-AMPK signaling cascade
G	0070852	cellular_component	cell body fiber
G	0071316	biological_process	cellular response to nicotine
G	0071333	biological_process	cellular response to glucose stimulus
G	0071356	biological_process	cellular response to tumor necrosis factor
G	0071805	biological_process	potassium ion transmembrane transport
G	0098662	biological_process	inorganic cation transmembrane transport
G	0098978	cellular_component	glutamatergic synapse
G	0099505	biological_process	regulation of presynaptic membrane potential
G	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	1904638	biological_process	response to resveratrol
G	1990573	biological_process	potassium ion import across plasma membrane
H	0001508	biological_process	action potential
H	0005267	molecular_function	potassium channel activity
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006813	biological_process	potassium ion transport
H	0008281	molecular_function	sulfonylurea receptor activity
H	0008282	cellular_component	inward rectifying potassium channel
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
H	0031669	biological_process	cellular response to nutrient levels
H	0032991	cellular_component	protein-containing complex
H	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
H	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
H	0043531	molecular_function	ADP binding
H	0044325	molecular_function	transmembrane transporter binding
H	0046676	biological_process	negative regulation of insulin secretion
H	0050905	biological_process	neuromuscular process
H	0055085	biological_process	transmembrane transport
H	0061535	biological_process	glutamate secretion, neurotransmission
H	0071805	biological_process	potassium ion transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport
H	0098662	biological_process	inorganic cation transmembrane transport
H	0098793	cellular_component	presynapse
H	0140359	molecular_function	ABC-type transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue AGS A 401

Chain	Residue
A	ASN48
A	ILE49
A	ARG50
C	ILE182
C	PHE183
C	LYS185
C	TYR330
C	GLY334

site_id	AC2
Number of Residues	10
Details	binding site for residue AGS B 2501

Chain	Residue
B	SER405
B	TRP688
B	GLY716
B	CYS717
B	GLY718
B	LYS719
B	SER720
B	SER721
B	GLN775
B	THR404

site_id	AC3
Number of Residues	8
Details	binding site for residue AGS C 401

Chain	Residue
C	ASN48
C	ILE49
C	ARG50
E	ILE182
E	PHE183
E	LYS185
E	TYR330
E	GLY334

site_id	AC4
Number of Residues	10
Details	binding site for residue AGS D 2501

Chain	Residue
D	THR404
D	SER405
D	TRP688
D	GLY716
D	CYS717
D	GLY718
D	LYS719
D	SER720
D	SER721
D	GLN775

site_id	AC5
Number of Residues	8
Details	binding site for residue AGS E 401

Chain	Residue
E	ASN48
E	ILE49
E	ARG50
G	ILE182
G	PHE183
G	LYS185
G	TYR330
G	GLY334

site_id	AC6
Number of Residues	10
Details	binding site for residue AGS F 2501

Chain	Residue
F	THR404
F	SER405
F	TRP688
F	GLY716
F	CYS717
F	GLY718
F	LYS719
F	SER720
F	SER721
F	GLN775

site_id	AC7
Number of Residues	8
Details	binding site for residue AGS G 401

Chain	Residue
A	ILE182
A	PHE183
A	LYS185
A	TYR330
A	GLY334
G	ASN48
G	ILE49
G	ARG50

site_id	AC8
Number of Residues	10
Details	binding site for residue AGS H 2501

Chain	Residue
H	THR404
H	SER405
H	TRP688
H	GLY716
H	CYS717
H	GLY718
H	LYS719
H	SER720
H	SER721
H	GLN775

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
B	LEU830-LEU844
B	PHE1482-PHE1496

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1160
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
A	MET1-TRP68
A	ILE167-SER390
C	MET1-TRP68
C	ILE167-SER390
E	MET1-TRP68
E	ILE167-SER390
G	MET1-TRP68
G	ILE167-SER390

site_id	SWS_FT_FI2
Number of Residues	96
Details	TRANSMEM: Helical; Name=M1 => ECO:0000250

Chain	Residue	Details
A	PRO69-ILE93
C	PRO69-ILE93
E	PRO69-ILE93
G	PRO69-ILE93

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Extracellular => ECO:0000250

Chain	Residue	Details
A	ALA94-SER116
A	ARG136-LEU144
C	ALA94-SER116
C	ARG136-LEU144
E	ALA94-SER116
E	ARG136-LEU144
G	ALA94-SER116
G	ARG136-LEU144

site_id	SWS_FT_FI4
Number of Residues	44
Details	INTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250

Chain	Residue	Details
A	PHE117-GLN128
C	PHE117-GLN128
E	PHE117-GLN128
G	PHE117-GLN128

site_id	SWS_FT_FI5
Number of Residues	24
Details	INTRAMEM: Pore-forming => ECO:0000250

Chain	Residue	Details
A	VAL129-GLY135
C	VAL129-GLY135
E	VAL129-GLY135
G	VAL129-GLY135

site_id	SWS_FT_FI6
Number of Residues	84
Details	TRANSMEM: Helical; Name=M2 => ECO:0000250

Chain	Residue	Details
A	ALA145-CYS166
C	ALA145-CYS166
E	ALA145-CYS166
G	ALA145-CYS166

site_id	SWS_FT_FI7
Number of Residues	4
Details	SITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250

Chain	Residue	Details
A	ASN160
C	ASN160
E	ASN160
G	ASN160

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAPK1 => ECO:0000250\|UniProtKB:Q14654

Chain	Residue	Details
A	THR341
C	THR341
E	THR341
G	THR341

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK1 => ECO:0000250\|UniProtKB:Q14654

Chain	Residue	Details
A	SER385
C	SER385
E	SER385
G	SER385

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)