5YVW
Crystal structure of full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue EPE B 701 |
| Chain | Residue |
| B | LEU193 |
| B | GLY414 |
| B | ASN416 |
| B | GLN456 |
| B | ARG460 |
| B | ARG463 |
| B | HIS194 |
| B | PRO195 |
| B | GLY196 |
| B | ALA197 |
| B | GLY198 |
| B | LYS199 |
| B | GLU285 |
| B | ALA316 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860 |
| Chain | Residue | Details |
| B | HIS51 | |
| B | ASP75 | |
| B | ALA135 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| B | LEU193 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335 |
| Chain | Residue | Details |
| B | ARG457 | |
| B | ARG460 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990 |
| Chain | Residue | Details |
| B | LYS618 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| B | LYS388 |
