5YVV

Crystal structure of full length NS3 protein (gD4NS2BNS3) from DENV4 in closed conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0044423	cellular_component	virion component
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
B	HIS51
B	ASP75
B	SER135

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
B	LEU193

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
B	ARG457
B	ARG460

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990

Chain	Residue	Details
B	LYS618

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
B	LYS388

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