5YTA
Pig Heart Lactate Dehydrogenase in complex with NADH and Oxamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | GLY30 |
| A | VAL99 |
| A | ARG100 |
| A | VAL117 |
| A | ILE121 |
| A | VAL137 |
| A | SER138 |
| A | ASN139 |
| A | SER162 |
| A | LEU166 |
| A | HIS194 |
| A | GLN31 |
| A | THR249 |
| A | ILE253 |
| A | OXM402 |
| A | HOH506 |
| A | HOH520 |
| A | HOH521 |
| A | HOH533 |
| A | HOH534 |
| A | HOH536 |
| A | HOH545 |
| A | VAL32 |
| A | HOH547 |
| A | HOH566 |
| A | ASP53 |
| A | VAL54 |
| A | LEU55 |
| A | THR96 |
| A | ALA97 |
| A | GLY98 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue OXM A 402 |
| Chain | Residue |
| A | GLN101 |
| A | ARG107 |
| A | ASN139 |
| A | ARG170 |
| A | HIS194 |
| A | ALA239 |
| A | THR249 |
| A | NAD401 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | GLY30 |
| B | GLN31 |
| B | VAL32 |
| B | ASP53 |
| B | VAL54 |
| B | LEU55 |
| B | THR96 |
| B | ALA97 |
| B | GLY98 |
| B | VAL99 |
| B | ARG100 |
| B | VAL117 |
| B | VAL137 |
| B | SER138 |
| B | ASN139 |
| B | SER162 |
| B | LEU166 |
| B | HIS194 |
| B | THR249 |
| B | ILE253 |
| B | OXM402 |
| B | HOH501 |
| B | HOH504 |
| B | HOH509 |
| B | HOH510 |
| B | HOH515 |
| B | HOH524 |
| B | HOH540 |
| B | HOH551 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue OXM B 402 |
| Chain | Residue |
| B | GLN101 |
| B | ARG107 |
| B | ASN139 |
| B | LEU166 |
| B | ARG170 |
| B | HIS194 |
| B | ALA239 |
| B | THR249 |
| B | NAD401 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU191-SER197 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"838465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P07195","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07195","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P07195","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
