5YSY

Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2R,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 90L A 501

Chain	Residue
A	THR142
A	TRP286
A	VAL300
A	HIS305
A	HIS397
A	HOH626
A	TYR143
A	ASP144
A	LEU227
A	LEU233
A	SER237
A	ARG274
A	SER275
A	SER278

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1DB1, ECO:0007744|PDB:1IE8

Chain	Residue	Details
A	TYR143
A	ARG274

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1DB1

Chain	Residue	Details
A	SER237

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1IE8

Chain	Residue	Details
A	SER278
A	HIS305

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298

Chain	Residue	Details
A	HIS397

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