Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5YQG

The structure of 14-3-3 and pNumb peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002028	biological_process	regulation of sodium ion transport
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006713	biological_process	glucocorticoid catabolic process
A	0006886	biological_process	intracellular protein transport
A	0007010	biological_process	cytoskeleton organization
A	0007088	biological_process	regulation of mitotic nuclear division
A	0007165	biological_process	signal transduction
A	0008104	biological_process	intracellular protein localization
A	0014704	cellular_component	intercalated disc
A	0017080	molecular_function	sodium channel regulator activity
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0035259	molecular_function	nuclear glucocorticoid receptor binding
A	0042802	molecular_function	identical protein binding
A	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
A	0043066	biological_process	negative regulation of apoptotic process
A	0044325	molecular_function	transmembrane transporter binding
A	0045184	biological_process	establishment of protein localization
A	0045202	cellular_component	synapse
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046982	molecular_function	protein heterodimerization activity
A	0050774	biological_process	negative regulation of dendrite morphogenesis
A	0086010	biological_process	membrane depolarization during action potential
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse
B	0002028	biological_process	regulation of sodium ion transport
B	0003779	molecular_function	actin binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006713	biological_process	glucocorticoid catabolic process
B	0006886	biological_process	intracellular protein transport
B	0007010	biological_process	cytoskeleton organization
B	0007088	biological_process	regulation of mitotic nuclear division
B	0007165	biological_process	signal transduction
B	0008104	biological_process	intracellular protein localization
B	0014704	cellular_component	intercalated disc
B	0017080	molecular_function	sodium channel regulator activity
B	0019899	molecular_function	enzyme binding
B	0019904	molecular_function	protein domain specific binding
B	0035259	molecular_function	nuclear glucocorticoid receptor binding
B	0042802	molecular_function	identical protein binding
B	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
B	0043066	biological_process	negative regulation of apoptotic process
B	0044325	molecular_function	transmembrane transporter binding
B	0045184	biological_process	establishment of protein localization
B	0045202	cellular_component	synapse
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046982	molecular_function	protein heterodimerization activity
B	0050774	biological_process	negative regulation of dendrite morphogenesis
B	0086010	biological_process	membrane depolarization during action potential
B	0098793	cellular_component	presynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
B	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse
C	0002028	biological_process	regulation of sodium ion transport
C	0003779	molecular_function	actin binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006713	biological_process	glucocorticoid catabolic process
C	0006886	biological_process	intracellular protein transport
C	0007010	biological_process	cytoskeleton organization
C	0007088	biological_process	regulation of mitotic nuclear division
C	0007165	biological_process	signal transduction
C	0008104	biological_process	intracellular protein localization
C	0014704	cellular_component	intercalated disc
C	0017080	molecular_function	sodium channel regulator activity
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0035259	molecular_function	nuclear glucocorticoid receptor binding
C	0042802	molecular_function	identical protein binding
C	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
C	0043066	biological_process	negative regulation of apoptotic process
C	0044325	molecular_function	transmembrane transporter binding
C	0045184	biological_process	establishment of protein localization
C	0045202	cellular_component	synapse
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046982	molecular_function	protein heterodimerization activity
C	0050774	biological_process	negative regulation of dendrite morphogenesis
C	0086010	biological_process	membrane depolarization during action potential
C	0098793	cellular_component	presynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
C	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse
D	0002028	biological_process	regulation of sodium ion transport
D	0003779	molecular_function	actin binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006713	biological_process	glucocorticoid catabolic process
D	0006886	biological_process	intracellular protein transport
D	0007010	biological_process	cytoskeleton organization
D	0007088	biological_process	regulation of mitotic nuclear division
D	0007165	biological_process	signal transduction
D	0008104	biological_process	intracellular protein localization
D	0014704	cellular_component	intercalated disc
D	0017080	molecular_function	sodium channel regulator activity
D	0019899	molecular_function	enzyme binding
D	0019904	molecular_function	protein domain specific binding
D	0035259	molecular_function	nuclear glucocorticoid receptor binding
D	0042802	molecular_function	identical protein binding
D	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
D	0043066	biological_process	negative regulation of apoptotic process
D	0044325	molecular_function	transmembrane transporter binding
D	0045184	biological_process	establishment of protein localization
D	0045202	cellular_component	synapse
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046982	molecular_function	protein heterodimerization activity
D	0050774	biological_process	negative regulation of dendrite morphogenesis
D	0086010	biological_process	membrane depolarization during action potential
D	0098793	cellular_component	presynapse
D	0098978	cellular_component	glutamatergic synapse
D	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
D	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG42-VAL52

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR216-SER235

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"UniProtKB","id":"Q04917","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q04917","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9705322","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CaMK1","evidences":[{"source":"UniProtKB","id":"Q2LC84","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)