5YL5
Crystal structure of dodecameric Dehydroquinate dehydratase from Acinetobacter baumannii at 1.9A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0009423 | biological_process | chorismate biosynthetic process |
A | 0016829 | molecular_function | lyase activity |
A | 0019631 | biological_process | quinate catabolic process |
B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0009423 | biological_process | chorismate biosynthetic process |
B | 0016829 | molecular_function | lyase activity |
B | 0019631 | biological_process | quinate catabolic process |
C | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
C | 0009423 | biological_process | chorismate biosynthetic process |
C | 0016829 | molecular_function | lyase activity |
C | 0019631 | biological_process | quinate catabolic process |
D | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
D | 0008652 | biological_process | amino acid biosynthetic process |
D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
D | 0009423 | biological_process | chorismate biosynthetic process |
D | 0016829 | molecular_function | lyase activity |
D | 0019631 | biological_process | quinate catabolic process |
E | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
E | 0008652 | biological_process | amino acid biosynthetic process |
E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
E | 0009423 | biological_process | chorismate biosynthetic process |
E | 0016829 | molecular_function | lyase activity |
E | 0019631 | biological_process | quinate catabolic process |
F | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
F | 0008652 | biological_process | amino acid biosynthetic process |
F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
F | 0009423 | biological_process | chorismate biosynthetic process |
F | 0016829 | molecular_function | lyase activity |
F | 0019631 | biological_process | quinate catabolic process |
G | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
G | 0008652 | biological_process | amino acid biosynthetic process |
G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
G | 0009423 | biological_process | chorismate biosynthetic process |
G | 0016829 | molecular_function | lyase activity |
G | 0019631 | biological_process | quinate catabolic process |
H | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
H | 0008652 | biological_process | amino acid biosynthetic process |
H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
H | 0009423 | biological_process | chorismate biosynthetic process |
H | 0016829 | molecular_function | lyase activity |
H | 0019631 | biological_process | quinate catabolic process |
I | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
I | 0008652 | biological_process | amino acid biosynthetic process |
I | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
I | 0009423 | biological_process | chorismate biosynthetic process |
I | 0016829 | molecular_function | lyase activity |
I | 0019631 | biological_process | quinate catabolic process |
J | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
J | 0008652 | biological_process | amino acid biosynthetic process |
J | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
J | 0009423 | biological_process | chorismate biosynthetic process |
J | 0016829 | molecular_function | lyase activity |
J | 0019631 | biological_process | quinate catabolic process |
K | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
K | 0008652 | biological_process | amino acid biosynthetic process |
K | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
K | 0009423 | biological_process | chorismate biosynthetic process |
K | 0016829 | molecular_function | lyase activity |
K | 0019631 | biological_process | quinate catabolic process |
L | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
L | 0008652 | biological_process | amino acid biosynthetic process |
L | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
L | 0009423 | biological_process | chorismate biosynthetic process |
L | 0016829 | molecular_function | lyase activity |
L | 0019631 | biological_process | quinate catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 201 |
Chain | Residue |
A | ASN76 |
A | HIS102 |
A | LEU103 |
A | SER104 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue SO4 A 202 |
Chain | Residue |
B | GLU55 |
B | GLY56 |
C | TRP54 |
C | GLU55 |
C | GLY56 |
A | TRP54 |
A | GLU55 |
A | GLY56 |
A | HOH308 |
A | HOH321 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue GOL A 203 |
Chain | Residue |
A | GLU55 |
A | THR83 |
A | SER84 |
B | GLU55 |
B | THR83 |
C | GLU55 |
C | THR83 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 201 |
Chain | Residue |
B | ASN76 |
B | HIS102 |
B | LEU103 |
B | SER104 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue SO4 C 201 |
Chain | Residue |
C | TYR24 |
C | ASN76 |
C | HIS102 |
C | LEU103 |
C | SER104 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue SO4 D 201 |
Chain | Residue |
D | ASN76 |
D | HIS102 |
D | LEU103 |
D | SER104 |
D | HOH309 |
site_id | AC7 |
Number of Residues | 10 |
Details | binding site for residue TRS D 202 |
Chain | Residue |
D | GLU55 |
D | THR83 |
D | SER84 |
H | GLU55 |
H | THR83 |
H | SER84 |
H | HOH301 |
L | GLU55 |
L | THR83 |
L | SER84 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue SO4 E 201 |
Chain | Residue |
E | ASN76 |
E | HIS102 |
E | LEU103 |
E | SER104 |
E | HOH343 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue SO4 E 202 |
Chain | Residue |
E | GLU55 |
E | GLY56 |
E | HOH321 |
F | TRP54 |
F | GLU55 |
F | GLY56 |
G | TRP54 |
G | GLU55 |
G | GLY56 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue GOL E 203 |
Chain | Residue |
E | GLU20 |
E | HOH331 |
K | PHE50 |
K | ALA57 |
K | ARG61 |
K | GLN64 |
site_id | AD2 |
Number of Residues | 8 |
Details | binding site for residue GOL E 204 |
Chain | Residue |
E | GLU20 |
E | PRO21 |
E | GLU22 |
E | HOH317 |
J | SER52 |
J | ASN53 |
J | TRP54 |
K | ASP60 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue GOL E 205 |
Chain | Residue |
E | GLU22 |
I | TRP54 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue SO4 F 201 |
Chain | Residue |
F | ASN76 |
F | HIS102 |
F | LEU103 |
F | SER104 |
F | HOH327 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue SO4 G 201 |
Chain | Residue |
G | ASN76 |
G | HIS102 |
G | LEU103 |
G | SER104 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue SO4 H 201 |
Chain | Residue |
H | ASN76 |
H | HIS102 |
H | LEU103 |
H | SER104 |
H | HOH323 |
site_id | AD7 |
Number of Residues | 11 |
Details | binding site for residue SO4 H 202 |
Chain | Residue |
L | HOH311 |
D | TRP54 |
D | GLU55 |
D | GLY56 |
H | GLU55 |
H | GLY56 |
H | HOH301 |
H | HOH305 |
H | HOH308 |
L | TRP54 |
L | GLY56 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue SO4 I 201 |
Chain | Residue |
I | ASN76 |
I | HIS102 |
I | LEU103 |
I | SER104 |
site_id | AD9 |
Number of Residues | 9 |
Details | binding site for residue SO4 I 202 |
Chain | Residue |
I | GLU55 |
I | GLY56 |
I | HOH305 |
I | HOH307 |
I | HOH316 |
J | GLY56 |
K | TRP54 |
K | GLU55 |
K | GLY56 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue SO4 J 201 |
Chain | Residue |
J | ASN76 |
J | HIS102 |
J | LEU103 |
J | SER104 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue SO4 K 201 |
Chain | Residue |
K | ASN76 |
K | HIS102 |
K | LEU103 |
K | SER104 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue SO4 L 201 |
Chain | Residue |
L | ASN76 |
L | HIS102 |
L | LEU103 |
L | SER104 |
Functional Information from PROSITE/UniProt
site_id | PS01029 |
Number of Residues | 18 |
Details | DEHYDROQUINASE_II Dehydroquinase class II signature. IHGPNLnlLGkREpevYG |
Chain | Residue | Details |
A | ILE8-GLY25 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 |
Chain | Residue | Details |
A | TYR24 | |
J | TYR24 | |
K | TYR24 | |
L | TYR24 | |
B | TYR24 | |
C | TYR24 | |
D | TYR24 | |
E | TYR24 | |
F | TYR24 | |
G | TYR24 | |
H | TYR24 | |
I | TYR24 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 |
Chain | Residue | Details |
A | HIS102 | |
J | HIS102 | |
K | HIS102 | |
L | HIS102 | |
B | HIS102 | |
C | HIS102 | |
D | HIS102 | |
E | HIS102 | |
F | HIS102 | |
G | HIS102 | |
H | HIS102 | |
I | HIS102 |
site_id | SWS_FT_FI3 |
Number of Residues | 60 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00169 |
Chain | Residue | Details |
A | ASN76 | |
B | ARG113 | |
C | ASN76 | |
C | HIS82 | |
C | ASP89 | |
C | LEU103 | |
C | ARG113 | |
D | ASN76 | |
D | HIS82 | |
D | ASP89 | |
D | LEU103 | |
A | HIS82 | |
D | ARG113 | |
E | ASN76 | |
E | HIS82 | |
E | ASP89 | |
E | LEU103 | |
E | ARG113 | |
F | ASN76 | |
F | HIS82 | |
F | ASP89 | |
F | LEU103 | |
A | ASP89 | |
F | ARG113 | |
G | ASN76 | |
G | HIS82 | |
G | ASP89 | |
G | LEU103 | |
G | ARG113 | |
H | ASN76 | |
H | HIS82 | |
H | ASP89 | |
H | LEU103 | |
A | LEU103 | |
H | ARG113 | |
I | ASN76 | |
I | HIS82 | |
I | ASP89 | |
I | LEU103 | |
I | ARG113 | |
J | ASN76 | |
J | HIS82 | |
J | ASP89 | |
J | LEU103 | |
A | ARG113 | |
J | ARG113 | |
K | ASN76 | |
K | HIS82 | |
K | ASP89 | |
K | LEU103 | |
K | ARG113 | |
L | ASN76 | |
L | HIS82 | |
L | ASP89 | |
L | LEU103 | |
B | ASN76 | |
L | ARG113 | |
B | HIS82 | |
B | ASP89 | |
B | LEU103 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 |
Chain | Residue | Details |
A | ARG19 | |
J | ARG19 | |
K | ARG19 | |
L | ARG19 | |
B | ARG19 | |
C | ARG19 | |
D | ARG19 | |
E | ARG19 | |
F | ARG19 | |
G | ARG19 | |
H | ARG19 | |
I | ARG19 |