5YJA

Crystal structure of highly active BTUO mutant P287G without dehydration

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0006144	biological_process	purine nucleobase metabolic process
B	0004846	molecular_function	urate oxidase activity
B	0006144	biological_process	purine nucleobase metabolic process
C	0004846	molecular_function	urate oxidase activity
C	0006144	biological_process	purine nucleobase metabolic process
D	0004846	molecular_function	urate oxidase activity
D	0006144	biological_process	purine nucleobase metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue AZA A 401

Chain	Residue
A	PHE184
B	ALA72
B	THR73
A	ARG201
A	SER248
A	ILE249
A	GLN250
A	ASN276
A	OXY402
A	HOH550
B	TYR11

---

site_id	AC2
Number of Residues	6
Details	binding site for residue OXY A 402

Chain	Residue
A	ASN276
A	GLY302
A	GLN304
A	AZA401
B	THR73
B	HOH640

---

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 403

Chain	Residue
A	ARG298
C	ARG298

---

site_id	AC4
Number of Residues	11
Details	binding site for residue AZA B 401

Chain	Residue
A	TYR11
A	ALA72
A	THR73
B	PHE184
B	ARG201
B	SER248
B	ILE249
B	GLN250
B	ASN276
B	OXY402
B	HOH515

---

site_id	AC5
Number of Residues	6
Details	binding site for residue OXY B 402

Chain	Residue
A	THR73
B	ASN276
B	GLY302
B	GLN304
B	AZA401
B	HOH527

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 B 403

Chain	Residue
B	ARG298
D	ARG298

---

site_id	AC7
Number of Residues	3
Details	binding site for residue K B 404

Chain	Residue
B	ILE32
B	SER35
C	ARG133

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MXE B 405

Chain	Residue
B	GLU119
B	PRO121
B	GLU146
B	ARG234
B	HOH591
B	HOH656

---

site_id	AC9
Number of Residues	11
Details	binding site for residue AZA C 401

Chain	Residue
C	PHE184
C	ARG201
C	SER248
C	ILE249
C	GLN250
C	ASN276
C	OXY402
C	HOH524
D	TYR11
D	ALA72
D	THR73

---

site_id	AD1
Number of Residues	5
Details	binding site for residue OXY C 402

Chain	Residue
C	ASN276
C	GLY302
C	GLN304
C	AZA401
D	THR73

---

site_id	AD2
Number of Residues	3
Details	binding site for residue K C 403

Chain	Residue
B	ARG133
C	ILE32
C	SER35

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MXE C 404

Chain	Residue
C	GLU119
C	GLU146
C	GLU231
C	ARG234
C	HOH511
C	HOH648

---

site_id	AD4
Number of Residues	12
Details	binding site for residue AZA D 401

Chain	Residue
C	TYR11
C	ALA72
C	THR73
D	PHE184
D	ARG201
D	SER248
D	ILE249
D	GLN250
D	ASN276
D	OXY402
D	HOH560
D	HOH645

---

site_id	AD5
Number of Residues	6
Details	binding site for residue OXY D 402

Chain	Residue
C	THR73
C	HOH676
D	ASN276
D	GLY302
D	GLN304
D	AZA401

---

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LqLIKVSgNsFvgFirdeYttLpedsnR

Chain	Residue	Details
A	LEU174-ARG201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Charge relay system; for urate oxidase activity","evidences":[{"source":"UniProtKB","id":"D0VWQ1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of urate oxidase from Bacillus sp.","authoringGroup":["Mycobacterium tuberculosis structural genomics consortium (TB)"]}}]}

Chain

Residue

Details

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