5YIR

Crystal Structure of AnkB LIR/GABARAP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000421	cellular_component	autophagosome membrane
A	0000423	biological_process	mitophagy
A	0005515	molecular_function	protein binding
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0005886	cellular_component	plasma membrane
A	0005930	cellular_component	axoneme
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006995	biological_process	cellular response to nitrogen starvation
A	0008017	molecular_function	microtubule binding
A	0008429	molecular_function	phosphatidylethanolamine binding
A	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
A	0012505	cellular_component	endomembrane system
A	0015031	biological_process	protein transport
A	0015629	cellular_component	actin cytoskeleton
A	0031410	cellular_component	cytoplasmic vesicle
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0035020	biological_process	regulation of Rac protein signal transduction
A	0044297	cellular_component	cell body
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048487	molecular_function	beta-tubulin binding
A	0050811	molecular_function	GABA receptor binding
A	0097225	cellular_component	sperm midpiece
A	0097352	biological_process	autophagosome maturation
A	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A	0098982	cellular_component	GABA-ergic synapse
A	0099091	cellular_component	postsynaptic specialization, intracellular component
A	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000421	cellular_component	autophagosome membrane
B	0000423	biological_process	mitophagy
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005790	cellular_component	smooth endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005875	cellular_component	microtubule associated complex
B	0005886	cellular_component	plasma membrane
B	0005930	cellular_component	axoneme
B	0006914	biological_process	autophagy
B	0006915	biological_process	apoptotic process
B	0006995	biological_process	cellular response to nitrogen starvation
B	0008017	molecular_function	microtubule binding
B	0008429	molecular_function	phosphatidylethanolamine binding
B	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
B	0012505	cellular_component	endomembrane system
B	0015031	biological_process	protein transport
B	0015629	cellular_component	actin cytoskeleton
B	0031410	cellular_component	cytoplasmic vesicle
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0035020	biological_process	regulation of Rac protein signal transduction
B	0044297	cellular_component	cell body
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048487	molecular_function	beta-tubulin binding
B	0050811	molecular_function	GABA receptor binding
B	0097225	cellular_component	sperm midpiece
B	0097352	biological_process	autophagosome maturation
B	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B	0098982	cellular_component	GABA-ergic synapse
B	0099091	cellular_component	postsynaptic specialization, intracellular component
B	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
D	0000045	biological_process	autophagosome assembly
D	0000139	cellular_component	Golgi membrane
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000421	cellular_component	autophagosome membrane
D	0000423	biological_process	mitophagy
D	0005515	molecular_function	protein binding
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005790	cellular_component	smooth endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005875	cellular_component	microtubule associated complex
D	0005886	cellular_component	plasma membrane
D	0005930	cellular_component	axoneme
D	0006914	biological_process	autophagy
D	0006915	biological_process	apoptotic process
D	0006995	biological_process	cellular response to nitrogen starvation
D	0008017	molecular_function	microtubule binding
D	0008429	molecular_function	phosphatidylethanolamine binding
D	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
D	0012505	cellular_component	endomembrane system
D	0015031	biological_process	protein transport
D	0015629	cellular_component	actin cytoskeleton
D	0031410	cellular_component	cytoplasmic vesicle
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0035020	biological_process	regulation of Rac protein signal transduction
D	0044297	cellular_component	cell body
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048487	molecular_function	beta-tubulin binding
D	0050811	molecular_function	GABA receptor binding
D	0097225	cellular_component	sperm midpiece
D	0097352	biological_process	autophagosome maturation
D	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
D	0098982	cellular_component	GABA-ergic synapse
D	0099091	cellular_component	postsynaptic specialization, intracellular component
D	1902524	biological_process	positive regulation of protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NI D 201

Chain	Residue
D	HIS99
D	GLU112
D	HOH303
D	HOH304

---

site_id	AC2
Number of Residues	2
Details	binding site for residue NI D 202

Chain	Residue
D	GLU97
D	HIS98

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NI D 203

Chain	Residue
G	HOH2103
C	HOH2101
D	HIS9
G	GLU1995

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NI A 201

Chain	Residue
A	HIS99
A	GLU112
A	HOH301
A	HOH303

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NI A 202

Chain	Residue
A	HIS69
A	HOH304
B	HIS69
B	HOH301

---

site_id	AC6
Number of Residues	4
Details	binding site for residue NI A 203

Chain	Residue
A	HIS9
A	HOH305
G	GLU1987
G	HOH2101

---

site_id	AC7
Number of Residues	1
Details	binding site for residue NI A 204

Chain	Residue
A	HIS98

---

site_id	AC8
Number of Residues	5
Details	binding site for residue NI B 201

Chain	Residue
B	HIS9
D	HIS69
D	HOH307
H	GLU1987
H	HOH2101

---

site_id	AC9
Number of Residues	4
Details	binding site for residue NI B 202

Chain	Residue
B	HIS99
B	GLU112
B	HOH303
B	HOH304

---

site_id	AD1
Number of Residues	2
Details	binding site for residue NI B 203

Chain	Residue
B	GLU97
B	HIS98

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000423066","evidences":[{"source":"PubMed","id":"14530254","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	63
Details	Region: {"description":"Interaction with beta-tubulin","evidences":[{"source":"PubMed","id":"10899939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	243
Details	Region: {"description":"Interaction with GPHN","evidences":[{"source":"PubMed","id":"10900017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	96
Details	Region: {"description":"Interaction with GABRG2","evidences":[{"source":"UniProtKB","id":"O95166","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Region: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"UniProtKB","id":"O95166","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"UniProtKB","id":"O95166","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Site: {"description":"Cleavage; by ATG4B","evidences":[{"source":"PubMed","id":"14530254","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Lipidation: {"description":"Phosphatidylserine amidated glycine; alternate","evidences":[{"source":"UniProtKB","id":"O95166","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8C8R3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---