5YIL
Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 462 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| A | MET1-PRO9 | |
| A | LEU357-THR365 | |
| A | GLU414-ILE438 | |
| A | ALA491-THR538 | |
| A | TYR889-VAL898 | |
| A | GLU944-ILE972 | |
| A | VAL1019-HIS1049 | |
| B | MET1-PRO9 | |
| B | LEU357-THR365 | |
| B | GLU414-ILE438 | |
| B | ALA491-THR538 | |
| B | TYR889-VAL898 | |
| B | GLU944-ILE972 | |
| B | VAL1019-HIS1049 | |
| C | MET1-PRO9 | |
| C | LEU357-THR365 | |
| C | GLU414-ILE438 | |
| C | ALA491-THR538 | |
| C | TYR889-VAL898 | |
| C | GLU944-ILE972 | |
| C | VAL1019-HIS1049 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| A | ILE10-LEU28 | |
| B | ILE10-LEU28 | |
| C | ILE10-LEU28 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| A | LYS29-SER336 | |
| A | PHE386-ASN391 | |
| A | PHE458-ALA465 | |
| A | PHE556-PRO871 | |
| A | THR919-PHE924 | |
| A | GLY993-ASN998 | |
| B | LYS29-SER336 | |
| B | PHE386-ASN391 | |
| B | PHE458-ALA465 | |
| B | PHE556-PRO871 | |
| B | THR919-PHE924 | |
| B | GLY993-ASN998 | |
| C | LYS29-SER336 | |
| C | PHE386-ASN391 | |
| C | PHE458-ALA465 | |
| C | PHE556-PRO871 | |
| C | THR919-PHE924 | |
| C | GLY993-ASN998 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | ILE337-TYR356 | |
| B | ILE337-TYR356 | |
| C | ILE337-TYR356 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | LEU366-ALA385 | |
| B | LEU366-ALA385 | |
| C | LEU366-ALA385 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | THR392-VAL413 | |
| B | THR392-VAL413 | |
| C | THR392-VAL413 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | GLN439-ALA457 | |
| B | GLN439-ALA457 | |
| C | GLN439-ALA457 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | ILE466-PRO490 | |
| B | ILE466-PRO490 | |
| C | ILE466-PRO490 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | GLY539-LEU555 | |
| B | GLY539-LEU555 | |
| C | GLY539-LEU555 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=8 |
| Chain | Residue | Details |
| A | SER872-LEU888 | |
| B | SER872-LEU888 | |
| C | SER872-LEU888 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=9 |
| Chain | Residue | Details |
| A | MET899-LEU918 | |
| B | MET899-LEU918 | |
| C | MET899-LEU918 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=10 |
| Chain | Residue | Details |
| A | GLN925-VAL943 | |
| B | GLN925-VAL943 | |
| C | GLN925-VAL943 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=11 |
| Chain | Residue | Details |
| A | LEU973-ALA992 | |
| B | LEU973-ALA992 | |
| C | LEU973-ALA992 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=12 |
| Chain | Residue | Details |
| A | ALA999-PHE1018 | |
| B | ALA999-PHE1018 | |
| C | ALA999-PHE1018 |
