5YI6
CRISPR associated protein Cas6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0051607 | biological_process | defense response to virus |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0051607 | biological_process | defense response to virus |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004518 | molecular_function | nuclease activity |
| C | 0004519 | molecular_function | endonuclease activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| C | 0051607 | biological_process | defense response to virus |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004518 | molecular_function | nuclease activity |
| D | 0004519 | molecular_function | endonuclease activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| D | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | ILE140 |
| D | HOH454 |
| A | TYR149 |
| A | ASN155 |
| A | LYS157 |
| A | PO4302 |
| A | HOH445 |
| A | HOH480 |
| A | HOH603 |
| D | HOH412 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 302 |
| Chain | Residue |
| A | ASN155 |
| A | SER156 |
| A | GOL301 |
| A | HOH445 |
| D | LYS157 |
| D | HOH412 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 303 |
| Chain | Residue |
| A | GLU8 |
| A | GLU10 |
| A | ARG63 |
| A | LYS117 |
| A | PO4304 |
| A | HOH547 |
| B | LYS115 |
| B | LYS117 |
| B | PO4304 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 304 |
| Chain | Residue |
| A | LYS78 |
| A | TYR80 |
| A | PO4303 |
| A | HOH414 |
| A | HOH547 |
| B | LYS117 |
| B | PO4303 |
| B | PO4304 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 305 |
| Chain | Residue |
| A | ASN33 |
| A | LYS34 |
| A | SER37 |
| A | GLY213 |
| A | PO4306 |
| A | HOH403 |
| A | HOH406 |
| A | HOH544 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 306 |
| Chain | Residue |
| A | LYS34 |
| A | ASP101 |
| A | LYS103 |
| A | PO4305 |
| A | HOH405 |
| A | HOH406 |
| A | HOH407 |
| A | HOH481 |
| A | HOH546 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 307 |
| Chain | Residue |
| A | GLU228 |
| A | LYS229 |
| A | HOH411 |
| A | HOH552 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 308 |
| Chain | Residue |
| A | PHE125 |
| A | VAL211 |
| A | GLY213 |
| A | TYR215 |
| A | HOH403 |
| A | HOH501 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 301 |
| Chain | Residue |
| B | THR138 |
| B | ILE140 |
| B | LYS157 |
| B | PO4302 |
| C | ILE140 |
| C | GOL301 |
| C | HOH419 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 302 |
| Chain | Residue |
| B | ASN155 |
| B | SER156 |
| B | GOL301 |
| B | HOH421 |
| C | LYS157 |
| C | HOH419 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 303 |
| Chain | Residue |
| A | LYS115 |
| A | PO4304 |
| B | GLU8 |
| B | ARG63 |
| B | LYS117 |
| B | PO4304 |
| B | HOH406 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 304 |
| Chain | Residue |
| A | PO4303 |
| A | PO4304 |
| B | GLU10 |
| B | LYS78 |
| B | TYR80 |
| B | LYS115 |
| B | LYS117 |
| B | PO4303 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 305 |
| Chain | Residue |
| B | ARG195 |
| B | ASP199 |
| B | TYR201 |
| B | HOH442 |
| D | TYR26 |
| D | ARG195 |
| D | HOH406 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 306 |
| Chain | Residue |
| B | LYS34 |
| B | HOH511 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 307 |
| Chain | Residue |
| B | HOH483 |
| B | HOH560 |
| B | GLU228 |
| B | LYS229 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 301 |
| Chain | Residue |
| B | GOL301 |
| C | THR138 |
| C | ILE140 |
| C | LYS157 |
| C | PO4302 |
| C | HOH419 |
| C | HOH444 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 C 302 |
| Chain | Residue |
| B | LYS157 |
| C | ASN155 |
| C | SER156 |
| C | GOL301 |
| C | HOH419 |
| C | HOH452 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 C 303 |
| Chain | Residue |
| C | GLU8 |
| C | GLU10 |
| C | ARG63 |
| C | LYS117 |
| C | PO4304 |
| C | HOH429 |
| C | HOH574 |
| D | LYS115 |
| D | LYS117 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 C 304 |
| Chain | Residue |
| C | LYS78 |
| C | TYR80 |
| C | PO4303 |
| C | HOH434 |
| C | HOH574 |
| D | LYS117 |
| D | PO4304 |
| D | HOH401 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 C 305 |
| Chain | Residue |
| C | ASN33 |
| C | LYS34 |
| C | SER37 |
| C | GLY213 |
| C | PO4306 |
| C | HOH403 |
| C | HOH407 |
| C | HOH556 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 C 306 |
| Chain | Residue |
| C | LYS34 |
| C | ASP101 |
| C | LYS103 |
| C | PO4305 |
| C | HOH407 |
| C | HOH411 |
| C | HOH448 |
| C | HOH453 |
| C | HOH472 |
| C | HOH485 |
| C | HOH490 |
| C | HOH550 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 C 307 |
| Chain | Residue |
| C | GLU228 |
| C | LYS229 |
| C | HOH420 |
| C | HOH491 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 C 308 |
| Chain | Residue |
| C | LYS124 |
| C | PHE125 |
| C | GLY213 |
| C | TYR215 |
| C | ILE218 |
| C | HOH403 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| D | THR138 |
| D | ILE140 |
| D | TYR149 |
| D | LYS157 |
| D | PO4302 |
| D | HOH412 |
| D | HOH431 |
| D | HOH454 |
| D | HOH471 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 D 302 |
| Chain | Residue |
| A | LYS157 |
| D | ASN155 |
| D | SER156 |
| D | GOL301 |
| D | HOH412 |
| D | HOH471 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 303 |
| Chain | Residue |
| C | LYS115 |
| D | GLU8 |
| D | ARG63 |
| D | LYS117 |
| D | PO4304 |
| D | HOH401 |
| D | HOH410 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 D 304 |
| Chain | Residue |
| C | PO4304 |
| D | GLU10 |
| D | TYR80 |
| D | LYS115 |
| D | LYS117 |
| D | PO4303 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 305 |
| Chain | Residue |
| B | TYR26 |
| B | ARG195 |
| D | ARG195 |
| D | ASP199 |
| D | TYR201 |
| D | HOH406 |
| D | HOH496 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 306 |
| Chain | Residue |
| D | ASN33 |
| D | LYS34 |
| D | SER37 |
| D | HOH404 |
| D | HOH413 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 D 307 |
| Chain | Residue |
| D | GLU228 |
| D | LYS229 |
| D | HOH446 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q8U1S4 |
| Chain | Residue | Details |
| A | TYR32 | |
| B | TYR32 | |
| C | TYR32 | |
| D | TYR32 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8U1S4 |
| Chain | Residue | Details |
| A | HIS47 | |
| B | HIS47 | |
| C | HIS47 | |
| D | HIS47 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:Q8U1S4 |
| Chain | Residue | Details |
| A | LYS53 | |
| B | LYS53 | |
| C | LYS53 | |
| D | LYS53 |
