Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5YE7

The crystal structure of Lp-PLA2 in complex with a novel inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0009395biological_processphospholipid catabolic process
A0016486biological_processpeptide hormone processing
A0016787molecular_functionhydrolase activity
A0016788molecular_functionhydrolase activity, acting on ester bonds
A0034362cellular_componentlow-density lipoprotein particle
A0034364cellular_componenthigh-density lipoprotein particle
A0034374biological_processlow-density lipoprotein particle remodeling
A0034440biological_processlipid oxidation
A0034441biological_processplasma lipoprotein particle oxidation
A0034638biological_processphosphatidylcholine catabolic process
A0046469biological_processplatelet activating factor metabolic process
A0047499molecular_functioncalcium-independent phospholipase A2 activity
A0050729biological_processpositive regulation of inflammatory response
A0062234biological_processplatelet activating factor catabolic process
A0090026biological_processpositive regulation of monocyte chemotaxis
B0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0009395biological_processphospholipid catabolic process
B0016486biological_processpeptide hormone processing
B0016787molecular_functionhydrolase activity
B0016788molecular_functionhydrolase activity, acting on ester bonds
B0034362cellular_componentlow-density lipoprotein particle
B0034364cellular_componenthigh-density lipoprotein particle
B0034374biological_processlow-density lipoprotein particle remodeling
B0034440biological_processlipid oxidation
B0034441biological_processplasma lipoprotein particle oxidation
B0034638biological_processphosphatidylcholine catabolic process
B0046469biological_processplatelet activating factor metabolic process
B0047499molecular_functioncalcium-independent phospholipase A2 activity
B0050729biological_processpositive regulation of inflammatory response
B0062234biological_processplatelet activating factor catabolic process
B0090026biological_processpositive regulation of monocyte chemotaxis
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue 8U0 B 501
ChainResidue
BPHE110
BGLY152
BLEU153
BGLY154
BHIS272
BSER273
BGLN352
BPHE357
BLEU369

site_idAC2
Number of Residues5
Detailsbinding site for residue SO4 B 502
ChainResidue
AASN100
ALYS101
AARG122
BASP89
BASN90

site_idAC3
Number of Residues10
Detailsbinding site for residue 8U0 A 501
ChainResidue
ALEU107
APHE110
AGLY152
ALEU153
AGLY154
AHIS272
ASER273
AGLN352
APHE357
ALEU371

site_idAC4
Number of Residues7
Detailsbinding site for residue SO4 A 502
ChainResidue
ASER308
AARG309
AILE310
APRO311
ALYS339
BHIS241
BARG264

Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. IAVIGHSFGG
ChainResidueDetails
BILE267-GLY276

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:18784071
ChainResidueDetails
BSER273
ASER273

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10037, ECO:0000269|PubMed:18784071
ChainResidueDetails
BASP296
BHIS351
AASP296
AHIS351

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN423
AASN423

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon