5YD8

Crystal structure of human PCNA in complex with APIM of human ZRANB3

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
X	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
X	0000781	cellular_component	chromosome, telomeric region
X	0000785	cellular_component	chromatin
X	0003677	molecular_function	DNA binding
X	0003682	molecular_function	chromatin binding
X	0003684	molecular_function	damaged DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005652	cellular_component	nuclear lamina
X	0005654	cellular_component	nucleoplasm
X	0005657	cellular_component	replication fork
X	0005813	cellular_component	centrosome
X	0006260	biological_process	DNA replication
X	0006272	biological_process	leading strand elongation
X	0006275	biological_process	regulation of DNA replication
X	0006281	biological_process	DNA repair
X	0006298	biological_process	mismatch repair
X	0006325	biological_process	chromatin organization
X	0006974	biological_process	DNA damage response
X	0006979	biological_process	response to oxidative stress
X	0007507	biological_process	heart development
X	0019899	molecular_function	enzyme binding
X	0019985	biological_process	translesion synthesis
X	0030331	molecular_function	nuclear estrogen receptor binding
X	0030337	molecular_function	DNA polymerase processivity factor activity
X	0030855	biological_process	epithelial cell differentiation
X	0030894	cellular_component	replisome
X	0030971	molecular_function	receptor tyrosine kinase binding
X	0031297	biological_process	replication fork processing
X	0032139	molecular_function	dinucleotide insertion or deletion binding
X	0032355	biological_process	response to estradiol
X	0032405	molecular_function	MutLalpha complex binding
X	0033993	biological_process	response to lipid
X	0034644	biological_process	cellular response to UV
X	0035035	molecular_function	histone acetyltransferase binding
X	0042802	molecular_function	identical protein binding
X	0043596	cellular_component	nuclear replication fork
X	0043626	cellular_component	PCNA complex
X	0044849	biological_process	estrous cycle
X	0044877	molecular_function	protein-containing complex binding
X	0045739	biological_process	positive regulation of DNA repair
X	0045740	biological_process	positive regulation of DNA replication
X	0046686	biological_process	response to cadmium ion
X	0070062	cellular_component	extracellular exosome
X	0070182	molecular_function	DNA polymerase binding
X	0070301	biological_process	cellular response to hydrogen peroxide
X	0070557	cellular_component	PCNA-p21 complex
X	0071548	biological_process	response to dexamethasone
X	0097421	biological_process	liver regeneration
X	1902065	biological_process	response to L-glutamate
X	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
Y	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
Y	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
Y	0000781	cellular_component	chromosome, telomeric region
Y	0000785	cellular_component	chromatin
Y	0003677	molecular_function	DNA binding
Y	0003682	molecular_function	chromatin binding
Y	0003684	molecular_function	damaged DNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005652	cellular_component	nuclear lamina
Y	0005654	cellular_component	nucleoplasm
Y	0005657	cellular_component	replication fork
Y	0005813	cellular_component	centrosome
Y	0006260	biological_process	DNA replication
Y	0006272	biological_process	leading strand elongation
Y	0006275	biological_process	regulation of DNA replication
Y	0006281	biological_process	DNA repair
Y	0006298	biological_process	mismatch repair
Y	0006325	biological_process	chromatin organization
Y	0006974	biological_process	DNA damage response
Y	0006979	biological_process	response to oxidative stress
Y	0007507	biological_process	heart development
Y	0019899	molecular_function	enzyme binding
Y	0019985	biological_process	translesion synthesis
Y	0030331	molecular_function	nuclear estrogen receptor binding
Y	0030337	molecular_function	DNA polymerase processivity factor activity
Y	0030855	biological_process	epithelial cell differentiation
Y	0030894	cellular_component	replisome
Y	0030971	molecular_function	receptor tyrosine kinase binding
Y	0031297	biological_process	replication fork processing
Y	0032139	molecular_function	dinucleotide insertion or deletion binding
Y	0032355	biological_process	response to estradiol
Y	0032405	molecular_function	MutLalpha complex binding
Y	0033993	biological_process	response to lipid
Y	0034644	biological_process	cellular response to UV
Y	0035035	molecular_function	histone acetyltransferase binding
Y	0042802	molecular_function	identical protein binding
Y	0043596	cellular_component	nuclear replication fork
Y	0043626	cellular_component	PCNA complex
Y	0044849	biological_process	estrous cycle
Y	0044877	molecular_function	protein-containing complex binding
Y	0045739	biological_process	positive regulation of DNA repair
Y	0045740	biological_process	positive regulation of DNA replication
Y	0046686	biological_process	response to cadmium ion
Y	0070062	cellular_component	extracellular exosome
Y	0070182	molecular_function	DNA polymerase binding
Y	0070301	biological_process	cellular response to hydrogen peroxide
Y	0070557	cellular_component	PCNA-p21 complex
Y	0071548	biological_process	response to dexamethasone
Y	0097421	biological_process	liver regeneration
Y	1902065	biological_process	response to L-glutamate
Y	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
Z	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
Z	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
Z	0000781	cellular_component	chromosome, telomeric region
Z	0000785	cellular_component	chromatin
Z	0003677	molecular_function	DNA binding
Z	0003682	molecular_function	chromatin binding
Z	0003684	molecular_function	damaged DNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005652	cellular_component	nuclear lamina
Z	0005654	cellular_component	nucleoplasm
Z	0005657	cellular_component	replication fork
Z	0005813	cellular_component	centrosome
Z	0006260	biological_process	DNA replication
Z	0006272	biological_process	leading strand elongation
Z	0006275	biological_process	regulation of DNA replication
Z	0006281	biological_process	DNA repair
Z	0006298	biological_process	mismatch repair
Z	0006325	biological_process	chromatin organization
Z	0006974	biological_process	DNA damage response
Z	0006979	biological_process	response to oxidative stress
Z	0007507	biological_process	heart development
Z	0019899	molecular_function	enzyme binding
Z	0019985	biological_process	translesion synthesis
Z	0030331	molecular_function	nuclear estrogen receptor binding
Z	0030337	molecular_function	DNA polymerase processivity factor activity
Z	0030855	biological_process	epithelial cell differentiation
Z	0030894	cellular_component	replisome
Z	0030971	molecular_function	receptor tyrosine kinase binding
Z	0031297	biological_process	replication fork processing
Z	0032139	molecular_function	dinucleotide insertion or deletion binding
Z	0032355	biological_process	response to estradiol
Z	0032405	molecular_function	MutLalpha complex binding
Z	0033993	biological_process	response to lipid
Z	0034644	biological_process	cellular response to UV
Z	0035035	molecular_function	histone acetyltransferase binding
Z	0042802	molecular_function	identical protein binding
Z	0043596	cellular_component	nuclear replication fork
Z	0043626	cellular_component	PCNA complex
Z	0044849	biological_process	estrous cycle
Z	0044877	molecular_function	protein-containing complex binding
Z	0045739	biological_process	positive regulation of DNA repair
Z	0045740	biological_process	positive regulation of DNA replication
Z	0046686	biological_process	response to cadmium ion
Z	0070062	cellular_component	extracellular exosome
Z	0070182	molecular_function	DNA polymerase binding
Z	0070301	biological_process	cellular response to hydrogen peroxide
Z	0070557	cellular_component	PCNA-p21 complex
Z	0071548	biological_process	response to dexamethasone
Z	0097421	biological_process	liver regeneration
Z	1902065	biological_process	response to L-glutamate
Z	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
Y	ARG61-LEU79

---

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
Y	GLY34-PHE57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"17115032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38459011","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17108083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17130289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	186
Details	Region: {"description":"Interaction with NUDT15","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Motif: {"description":"APIM motif"}

Chain

Residue

Details

---