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5YAM

Solution structure of mice Met-CCL5/RANTES

Functional Information from GO Data
ChainGOidnamespacecontents
A0002230biological_processpositive regulation of defense response to virus by host
A0004435molecular_functionphosphatidylinositol phospholipase C activity
A0004672molecular_functionprotein kinase activity
A0005125molecular_functioncytokine activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006887biological_processexocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007159biological_processleukocyte cell-cell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0008201molecular_functionheparin binding
A0009636biological_processresponse to toxic substance
A0010628biological_processpositive regulation of gene expression
A0010759biological_processpositive regulation of macrophage chemotaxis
A0010820biological_processpositive regulation of T cell chemotaxis
A0014911biological_processpositive regulation of smooth muscle cell migration
A0016004molecular_functionphospholipase activator activity
A0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
A0030335biological_processpositive regulation of cell migration
A0031269biological_processpseudopodium assembly
A0031328biological_processpositive regulation of cellular biosynthetic process
A0031584biological_processactivation of phospholipase D activity
A0031622biological_processpositive regulation of fever generation
A0031726molecular_functionCCR1 chemokine receptor binding
A0031730molecular_functionCCR5 chemokine receptor binding
A0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
A0034097biological_processresponse to cytokine
A0034112biological_processpositive regulation of homotypic cell-cell adhesion
A0034341biological_processresponse to type II interferon
A0034612biological_processresponse to tumor necrosis factor
A0035688biological_processT-helper 1 cell diapedesis
A0042056molecular_functionchemoattractant activity
A0042102biological_processpositive regulation of T cell proliferation
A0042119biological_processneutrophil activation
A0042327biological_processpositive regulation of phosphorylation
A0042379molecular_functionchemokine receptor binding
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043067biological_processregulation of programmed cell death
A0043621molecular_functionobsolete protein self-association
A0043922biological_processnegative regulation by host of viral transcription
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045071biological_processnegative regulation of viral genome replication
A0045666biological_processpositive regulation of neuron differentiation
A0045672biological_processpositive regulation of osteoclast differentiation
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0045766biological_processpositive regulation of angiogenesis
A0045785biological_processpositive regulation of cell adhesion
A0046817molecular_functionchemokine receptor antagonist activity
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0048247biological_processlymphocyte chemotaxis
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0050796biological_processregulation of insulin secretion
A0050863biological_processregulation of T cell activation
A0050918biological_processpositive chemotaxis
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051928biological_processpositive regulation of calcium ion transport
A0060326biological_processcell chemotaxis
A0060754biological_processpositive regulation of mast cell chemotaxis
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070100biological_processnegative regulation of chemokine-mediated signaling pathway
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0090026biological_processpositive regulation of monocyte chemotaxis
A0098586biological_processcellular response to virus
A2000110biological_processnegative regulation of macrophage apoptotic process
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
A2000406biological_processpositive regulation of T cell migration
A2000503biological_processpositive regulation of natural killer cell chemotaxis
B0002230biological_processpositive regulation of defense response to virus by host
B0004435molecular_functionphosphatidylinositol phospholipase C activity
B0004672molecular_functionprotein kinase activity
B0005125molecular_functioncytokine activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006887biological_processexocytosis
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007159biological_processleukocyte cell-cell adhesion
B0007186biological_processG protein-coupled receptor signaling pathway
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0008201molecular_functionheparin binding
B0009636biological_processresponse to toxic substance
B0010628biological_processpositive regulation of gene expression
B0010759biological_processpositive regulation of macrophage chemotaxis
B0010820biological_processpositive regulation of T cell chemotaxis
B0014911biological_processpositive regulation of smooth muscle cell migration
B0016004molecular_functionphospholipase activator activity
B0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
B0030335biological_processpositive regulation of cell migration
B0031269biological_processpseudopodium assembly
B0031328biological_processpositive regulation of cellular biosynthetic process
B0031584biological_processactivation of phospholipase D activity
B0031622biological_processpositive regulation of fever generation
B0031726molecular_functionCCR1 chemokine receptor binding
B0031730molecular_functionCCR5 chemokine receptor binding
B0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
B0034097biological_processresponse to cytokine
B0034112biological_processpositive regulation of homotypic cell-cell adhesion
B0034341biological_processresponse to type II interferon
B0034612biological_processresponse to tumor necrosis factor
B0035688biological_processT-helper 1 cell diapedesis
B0042056molecular_functionchemoattractant activity
B0042102biological_processpositive regulation of T cell proliferation
B0042119biological_processneutrophil activation
B0042327biological_processpositive regulation of phosphorylation
B0042379molecular_functionchemokine receptor binding
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043067biological_processregulation of programmed cell death
B0043621molecular_functionobsolete protein self-association
B0043922biological_processnegative regulation by host of viral transcription
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0045071biological_processnegative regulation of viral genome replication
B0045666biological_processpositive regulation of neuron differentiation
B0045672biological_processpositive regulation of osteoclast differentiation
B0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
B0045766biological_processpositive regulation of angiogenesis
B0045785biological_processpositive regulation of cell adhesion
B0046817molecular_functionchemokine receptor antagonist activity
B0048020molecular_functionCCR chemokine receptor binding
B0048245biological_processeosinophil chemotaxis
B0048247biological_processlymphocyte chemotaxis
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050673biological_processepithelial cell proliferation
B0050679biological_processpositive regulation of epithelial cell proliferation
B0050796biological_processregulation of insulin secretion
B0050863biological_processregulation of T cell activation
B0050918biological_processpositive chemotaxis
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051928biological_processpositive regulation of calcium ion transport
B0060326biological_processcell chemotaxis
B0060754biological_processpositive regulation of mast cell chemotaxis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
B0070100biological_processnegative regulation of chemokine-mediated signaling pathway
B0070233biological_processnegative regulation of T cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0090026biological_processpositive regulation of monocyte chemotaxis
B0098586biological_processcellular response to virus
B2000110biological_processnegative regulation of macrophage apoptotic process
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B2000406biological_processpositive regulation of T cell migration
B2000503biological_processpositive regulation of natural killer cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFaylsla..LprahVkeYfytssk..Csnl.AVVFvtrrnrqv.CA
ChainResidueDetails
ACYS11-ALA52

219140

PDB entries from 2024-05-01

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