5YA1
crystal structure of LsrK-HPr complex with ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0009372 | biological_process | quorum sensing |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0044010 | biological_process | single-species biofilm formation |
| A | 0071518 | molecular_function | autoinducer-2 kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0009372 | biological_process | quorum sensing |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0044010 | biological_process | single-species biofilm formation |
| B | 0071518 | molecular_function | autoinducer-2 kinase activity |
| C | 0004857 | molecular_function | enzyme inhibitor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008047 | molecular_function | enzyme activator activity |
| C | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| C | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| C | 0030234 | molecular_function | enzyme regulator activity |
| C | 0043609 | biological_process | regulation of carbon utilization |
| C | 0045152 | molecular_function | antisigma factor binding |
| C | 0045819 | biological_process | positive regulation of glycogen catabolic process |
| D | 0004857 | molecular_function | enzyme inhibitor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008047 | molecular_function | enzyme activator activity |
| D | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| D | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| D | 0030234 | molecular_function | enzyme regulator activity |
| D | 0043609 | biological_process | regulation of carbon utilization |
| D | 0045152 | molecular_function | antisigma factor binding |
| D | 0045819 | biological_process | positive regulation of glycogen catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue ATP A 701 |
| Chain | Residue |
| A | GLY273 |
| A | HOH810 |
| A | GLY315 |
| A | MET318 |
| A | ARG319 |
| A | ARG322 |
| A | TYR341 |
| A | GLY428 |
| A | GLY432 |
| A | HOH805 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue HEZ A 702 |
| Chain | Residue |
| A | HIS127 |
| A | GLU134 |
| A | MET210 |
| A | PO4705 |
| C | ALA20 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue HEZ A 703 |
| Chain | Residue |
| A | MET92 |
| A | LEU261 |
| A | GLN278 |
| A | LYS453 |
| A | GLU454 |
| A | ALA455 |
| A | THR456 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 704 |
| Chain | Residue |
| A | LYS204 |
| A | PRO205 |
| A | HOH808 |
| B | LYS204 |
| B | PRO205 |
| B | HOH710 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 705 |
| Chain | Residue |
| A | HIS127 |
| A | HEZ702 |
| C | LYS24 |
| C | LYS27 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 706 |
| Chain | Residue |
| A | ASP197 |
| A | LYS204 |
| B | ASP197 |
| B | LYS204 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 707 |
| Chain | Residue |
| A | ARG265 |
| A | SER473 |
| A | ALA475 |
| A | GLU476 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue ATP B 601 |
| Chain | Residue |
| B | GLY273 |
| B | GLY315 |
| B | MET318 |
| B | ARG319 |
| B | ARG322 |
| B | TYR341 |
| B | GLY428 |
| B | LYS431 |
| B | GLY432 |
| B | HOH702 |
| B | HOH706 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue HEZ B 602 |
| Chain | Residue |
| B | HIS127 |
| B | GLU134 |
| B | ALA206 |
| B | MET210 |
| B | PO4604 |
| D | ALA20 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue HEZ B 603 |
| Chain | Residue |
| B | GLU454 |
| B | ALA455 |
| B | THR456 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 604 |
| Chain | Residue |
| B | HIS127 |
| B | HEZ602 |
| D | LYS24 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 605 |
| Chain | Residue |
| B | ARG265 |
| B | ALA475 |
| B | GLU476 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 C 101 |
| Chain | Residue |
| C | ASN38 |
| C | LYS40 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 D 101 |
| Chain | Residue |
| D | ASN38 |
| D | LYS40 |
| D | HOH201 |
Functional Information from PROSITE/UniProt
| site_id | PS00369 |
| Number of Residues | 8 |
| Details | PTS_HPR_HIS PTS HPR domain histidine phosphorylation site signature. GLHTRPAA |
| Chain | Residue | Details |
| C | GLY13-ALA20 |
| site_id | PS00589 |
| Number of Residues | 16 |
| Details | PTS_HPR_SER PTS HPR domain serine phosphorylation site signature. GKsASaKSLFKLQtLG |
| Chain | Residue | Details |
| C | GLY39-GLY54 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000255|PROSITE-ProRule:PRU00681, ECO:0000269|PubMed:2261470 |
| Chain | Residue | Details |
| C | HIS15 | |
| D | HIS15 |
