5Y8P
Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + 3-Hydroxy propionate (3-HP)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006574 | biological_process | valine catabolic process |
A | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
A | 0009083 | biological_process | branched-chain amino acid catabolic process |
A | 0016054 | biological_process | organic acid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0006574 | biological_process | valine catabolic process |
B | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
B | 0009083 | biological_process | branched-chain amino acid catabolic process |
B | 0016054 | biological_process | organic acid catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue GOL A 301 |
Chain | Residue |
A | HIS25 |
A | VAL26 |
A | VAL27 |
A | GLY44 |
A | THR76 |
A | LEU79 |
A | ALA80 |
A | HOH409 |
A | HOH504 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue 9ON A 302 |
Chain | Residue |
A | ARG145 |
A | GLU149 |
A | ALA152 |
A | GLY153 |
A | ILE155 |
A | HOH402 |
A | HOH473 |
A | HOH477 |
B | ALA253 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue 3OH B 301 |
Chain | Residue |
A | ALA274 |
A | ASP275 |
B | PHE236 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue GOL B 302 |
Chain | Residue |
B | PHE30 |
B | PRO32 |
B | LEU65 |
B | VAL70 |
B | HOH548 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue GOL B 303 |
Chain | Residue |
B | GLY10 |
B | ASN11 |
B | MET12 |
B | GLY13 |
B | MET64 |
B | HOH440 |
B | HOH524 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue AKR B 304 |
Chain | Residue |
B | ALA58 |
B | ARG83 |
B | PRO84 |
B | THR86 |
B | ARG143 |
site_id | AC7 |
Number of Residues | 10 |
Details | binding site for residue 9ON B 305 |
Chain | Residue |
B | ALA128 |
B | GLU149 |
B | ALA152 |
B | GLY153 |
B | LYS154 |
B | ILE155 |
B | HOH401 |
B | HOH474 |
B | HOH487 |
B | HOH558 |
Functional Information from PROSITE/UniProt
site_id | PS00895 |
Number of Residues | 14 |
Details | 3_HYDROXYISOBUT_DH 3-hydroxyisobutyrate dehydrogenase signature. FLGLGnMGapMSaN |
Chain | Residue | Details |
A | PHE6-ASN19 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000250 |
Chain | Residue | Details |
A | LYS168 | |
B | LYS168 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | THR3 | |
A | THR93 | |
A | LYS243 | |
B | THR3 | |
B | THR93 | |
B | LYS243 |