5Y8G
Mycobacterium tuberculosis 3-Hydroxyisobutyrate Dehydrogenase (MtHIBADH)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006574 | biological_process | L-valine catabolic process |
| A | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| A | 0009083 | biological_process | branched-chain amino acid catabolic process |
| A | 0016054 | biological_process | organic acid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0006574 | biological_process | L-valine catabolic process |
| B | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| B | 0009083 | biological_process | branched-chain amino acid catabolic process |
| B | 0016054 | biological_process | organic acid catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue AKR A 301 |
| Chain | Residue |
| A | ALA58 |
| A | ASP59 |
| A | ARG83 |
| A | PRO84 |
| A | ALA85 |
| A | THR86 |
| A | ARG143 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | VAL27 |
| A | GLY44 |
| A | THR76 |
| A | LEU79 |
| A | ALA80 |
| A | HOH485 |
| A | HOH527 |
| A | HIS25 |
| A | VAL26 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 9ON A 303 |
| Chain | Residue |
| A | ARG145 |
| A | GLU149 |
| A | ALA152 |
| A | GLY153 |
| A | LYS154 |
| A | ILE155 |
| A | HOH403 |
| A | HOH619 |
| B | ALA254 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue AKR B 301 |
| Chain | Residue |
| A | ALA274 |
| A | ASP275 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | GLY8 |
| B | PHE30 |
| B | PRO32 |
| B | LEU65 |
| B | CYS74 |
| B | HOH410 |
| B | HOH424 |
| B | HOH508 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | ALA58 |
| B | ASP59 |
| B | ARG83 |
| B | PRO84 |
| B | THR86 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue 9ON B 304 |
| Chain | Residue |
| B | ALA128 |
| B | GLU149 |
| B | ALA152 |
| B | GLY153 |
| B | LYS154 |
| B | HOH440 |
| B | HOH487 |
| B | HOH625 |
Functional Information from PROSITE/UniProt
| site_id | PS00895 |
| Number of Residues | 14 |
| Details | 3_HYDROXYISOBUT_DH 3-hydroxyisobutyrate dehydrogenase signature. FLGLGnMGapMSaN |
| Chain | Residue | Details |
| A | PHE6-ASN19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
