5Y88

Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000243	cellular_component	commitment complex
a	0000245	biological_process	spliceosomal complex assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000395	biological_process	mRNA 5'-splice site recognition
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003674	molecular_function	molecular_function
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005737	cellular_component	cytoplasm
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0032991	cellular_component	protein-containing complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0043229	cellular_component	intracellular organelle
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0070990	molecular_function	snRNP binding
a	0071001	cellular_component	U4/U6 snRNP
a	0071004	cellular_component	U2-type prespliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	1903241	biological_process	U2-type prespliceosome assembly
a	1990904	cellular_component	ribonucleoprotein complex
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
b	0000243	cellular_component	commitment complex
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000395	biological_process	mRNA 5'-splice site recognition
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0032991	cellular_component	protein-containing complex
b	0034715	cellular_component	pICln-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0043229	cellular_component	intracellular organelle
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071001	cellular_component	U4/U6 snRNP
b	0071004	cellular_component	U2-type prespliceosome
b	0071011	cellular_component	precatalytic spliceosome
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990935	molecular_function	splicing factor binding
c	0000243	cellular_component	commitment complex
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000395	biological_process	mRNA 5'-splice site recognition
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005737	cellular_component	cytoplasm
c	0006397	biological_process	mRNA processing
c	0008266	molecular_function	poly(U) RNA binding
c	0008380	biological_process	RNA splicing
c	0034715	cellular_component	pICln-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0071001	cellular_component	U4/U6 snRNP
c	0071013	cellular_component	catalytic step 2 spliceosome
c	0120114	cellular_component	Sm-like protein family complex
c	1903241	biological_process	U2-type prespliceosome assembly
c	1990935	molecular_function	splicing factor binding
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0000243	cellular_component	commitment complex
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000395	biological_process	mRNA 5'-splice site recognition
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003674	molecular_function	molecular_function
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005737	cellular_component	cytoplasm
d	0006397	biological_process	mRNA processing
d	0008150	biological_process	biological_process
d	0008380	biological_process	RNA splicing
d	0032991	cellular_component	protein-containing complex
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071001	cellular_component	U4/U6 snRNP
d	0071004	cellular_component	U2-type prespliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
e	0000243	cellular_component	commitment complex
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000395	biological_process	mRNA 5'-splice site recognition
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0003729	molecular_function	mRNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006396	biological_process	RNA processing
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0034715	cellular_component	pICln-Sm protein complex
e	0034719	cellular_component	SMN-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071001	cellular_component	U4/U6 snRNP
e	0071004	cellular_component	U2-type prespliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	0071013	cellular_component	catalytic step 2 spliceosome
e	0097525	cellular_component	spliceosomal snRNP complex
e	0097526	cellular_component	spliceosomal tri-snRNP complex
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
f	0000243	cellular_component	commitment complex
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000395	biological_process	mRNA 5'-splice site recognition
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0003729	molecular_function	mRNA binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006396	biological_process	RNA processing
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034715	cellular_component	pICln-Sm protein complex
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071001	cellular_component	U4/U6 snRNP
f	0071004	cellular_component	U2-type prespliceosome
f	0071011	cellular_component	precatalytic spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0097525	cellular_component	spliceosomal snRNP complex
f	0097526	cellular_component	spliceosomal tri-snRNP complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
g	0000243	cellular_component	commitment complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000395	biological_process	mRNA 5'-splice site recognition
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003674	molecular_function	molecular_function
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0008150	biological_process	biological_process
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0032991	cellular_component	protein-containing complex
g	0034715	cellular_component	pICln-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071001	cellular_component	U4/U6 snRNP
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
G	0000384	molecular_function	first spliceosomal transesterification activity
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0000974	cellular_component	Prp19 complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0071006	cellular_component	U2-type catalytic step 1 spliceosome
h	0000243	cellular_component	commitment complex
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000395	biological_process	mRNA 5'-splice site recognition
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003674	molecular_function	molecular_function
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005737	cellular_component	cytoplasm
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0032991	cellular_component	protein-containing complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0043229	cellular_component	intracellular organelle
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0070990	molecular_function	snRNP binding
h	0071001	cellular_component	U4/U6 snRNP
h	0071004	cellular_component	U2-type prespliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
H	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
H	0000384	molecular_function	first spliceosomal transesterification activity
H	0000386	molecular_function	second spliceosomal transesterification activity
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0000974	cellular_component	Prp19 complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005681	cellular_component	spliceosomal complex
H	0005829	cellular_component	cytosol
H	0006396	biological_process	RNA processing
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0071004	cellular_component	U2-type prespliceosome
H	0071006	cellular_component	U2-type catalytic step 1 spliceosome
H	0071007	cellular_component	U2-type catalytic step 2 spliceosome
H	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
H	0071014	cellular_component	post-mRNA release spliceosomal complex
i	0000243	cellular_component	commitment complex
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000395	biological_process	mRNA 5'-splice site recognition
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005737	cellular_component	cytoplasm
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0032991	cellular_component	protein-containing complex
i	0034715	cellular_component	pICln-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0043229	cellular_component	intracellular organelle
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0071001	cellular_component	U4/U6 snRNP
i	0071004	cellular_component	U2-type prespliceosome
i	0071011	cellular_component	precatalytic spliceosome
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990935	molecular_function	splicing factor binding
I	0000245	biological_process	spliceosomal complex assembly
I	0000354	biological_process	cis assembly of pre-catalytic spliceosome
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000785	cellular_component	chromatin
I	0000974	cellular_component	Prp19 complex
I	0003682	molecular_function	chromatin binding
I	0003688	molecular_function	DNA replication origin binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005681	cellular_component	spliceosomal complex
I	0006270	biological_process	DNA replication initiation
I	0006396	biological_process	RNA processing
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0071004	cellular_component	U2-type prespliceosome
I	0071006	cellular_component	U2-type catalytic step 1 spliceosome
I	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
I	0071014	cellular_component	post-mRNA release spliceosomal complex
j	0000243	cellular_component	commitment complex
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000395	biological_process	mRNA 5'-splice site recognition
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005737	cellular_component	cytoplasm
j	0006397	biological_process	mRNA processing
j	0008266	molecular_function	poly(U) RNA binding
j	0008380	biological_process	RNA splicing
j	0034715	cellular_component	pICln-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071001	cellular_component	U4/U6 snRNP
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0120114	cellular_component	Sm-like protein family complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990935	molecular_function	splicing factor binding
J	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
J	0000386	molecular_function	second spliceosomal transesterification activity
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0000974	cellular_component	Prp19 complex
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0005737	cellular_component	cytoplasm
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0071006	cellular_component	U2-type catalytic step 1 spliceosome
k	0000243	cellular_component	commitment complex
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000395	biological_process	mRNA 5'-splice site recognition
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003674	molecular_function	molecular_function
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005737	cellular_component	cytoplasm
k	0006397	biological_process	mRNA processing
k	0008150	biological_process	biological_process
k	0008380	biological_process	RNA splicing
k	0032991	cellular_component	protein-containing complex
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0071001	cellular_component	U4/U6 snRNP
k	0071004	cellular_component	U2-type prespliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
K	0000384	molecular_function	first spliceosomal transesterification activity
K	0000386	molecular_function	second spliceosomal transesterification activity
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000974	cellular_component	Prp19 complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0005829	cellular_component	cytosol
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071004	cellular_component	U2-type prespliceosome
K	0071006	cellular_component	U2-type catalytic step 1 spliceosome
K	0071007	cellular_component	U2-type catalytic step 2 spliceosome
K	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
l	0000243	cellular_component	commitment complex
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000395	biological_process	mRNA 5'-splice site recognition
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0003729	molecular_function	mRNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006396	biological_process	RNA processing
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0071001	cellular_component	U4/U6 snRNP
l	0071004	cellular_component	U2-type prespliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0097525	cellular_component	spliceosomal snRNP complex
l	0097526	cellular_component	spliceosomal tri-snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
L	0000282	biological_process	cellular bud site selection
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0005686	cellular_component	U2 snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
m	0000243	cellular_component	commitment complex
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000395	biological_process	mRNA 5'-splice site recognition
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0003729	molecular_function	mRNA binding
m	0005634	cellular_component	nucleus
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006396	biological_process	RNA processing
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034715	cellular_component	pICln-Sm protein complex
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0071001	cellular_component	U4/U6 snRNP
m	0071004	cellular_component	U2-type prespliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0097525	cellular_component	spliceosomal snRNP complex
m	0097526	cellular_component	spliceosomal tri-snRNP complex
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0003723	molecular_function	RNA binding
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0017070	molecular_function	U6 snRNA binding
M	0036002	molecular_function	pre-mRNA binding
M	0071006	cellular_component	U2-type catalytic step 1 spliceosome
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0000243	cellular_component	commitment complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000395	biological_process	mRNA 5'-splice site recognition
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003674	molecular_function	molecular_function
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008150	biological_process	biological_process
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0032991	cellular_component	protein-containing complex
n	0034715	cellular_component	pICln-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071001	cellular_component	U4/U6 snRNP
n	0071004	cellular_component	U2-type prespliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex
N	0000387	biological_process	spliceosomal snRNP assembly
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0000974	cellular_component	Prp19 complex
N	0003676	molecular_function	nucleic acid binding
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008270	molecular_function	zinc ion binding
N	0008380	biological_process	RNA splicing
N	0017070	molecular_function	U6 snRNA binding
N	0033120	biological_process	positive regulation of RNA splicing
N	0036002	molecular_function	pre-mRNA binding
N	0045292	biological_process	mRNA cis splicing, via spliceosome
N	0045787	biological_process	positive regulation of cell cycle
N	0046872	molecular_function	metal ion binding
N	0071006	cellular_component	U2-type catalytic step 1 spliceosome
N	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003674	molecular_function	molecular_function
o	0005634	cellular_component	nucleus
o	0005681	cellular_component	spliceosomal complex
o	0005686	cellular_component	U2 snRNP
o	0005737	cellular_component	cytoplasm
o	0006397	biological_process	mRNA processing
o	0008380	biological_process	RNA splicing
o	0030620	molecular_function	U2 snRNA binding
o	0071004	cellular_component	U2-type prespliceosome
o	1903241	biological_process	U2-type prespliceosome assembly
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0003674	molecular_function	molecular_function
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0071013	cellular_component	catalytic step 2 spliceosome
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0005634	cellular_component	nucleus
p	0005681	cellular_component	spliceosomal complex
p	0005686	cellular_component	U2 snRNP
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0030620	molecular_function	U2 snRNA binding
p	0071004	cellular_component	U2-type prespliceosome
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990904	cellular_component	ribonucleoprotein complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003674	molecular_function	molecular_function
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0005684	cellular_component	U2-type spliceosomal complex
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
q	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000974	cellular_component	Prp19 complex
q	0004842	molecular_function	ubiquitin-protein transferase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005681	cellular_component	spliceosomal complex
q	0005737	cellular_component	cytoplasm
q	0005739	cellular_component	mitochondrion
q	0005829	cellular_component	cytosol
q	0006281	biological_process	DNA repair
q	0006397	biological_process	mRNA processing
q	0008380	biological_process	RNA splicing
q	0016567	biological_process	protein ubiquitination
q	0016740	molecular_function	transferase activity
q	0042802	molecular_function	identical protein binding
q	0061630	molecular_function	ubiquitin protein ligase activity
q	0070534	biological_process	protein K63-linked ubiquitination
q	0071006	cellular_component	U2-type catalytic step 1 spliceosome
Q	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
Q	0000384	molecular_function	first spliceosomal transesterification activity
Q	0000386	molecular_function	second spliceosomal transesterification activity
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005681	cellular_component	spliceosomal complex
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0071006	cellular_component	U2-type catalytic step 1 spliceosome
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	0071014	cellular_component	post-mRNA release spliceosomal complex
r	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0000974	cellular_component	Prp19 complex
r	0004842	molecular_function	ubiquitin-protein transferase activity
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005681	cellular_component	spliceosomal complex
r	0005737	cellular_component	cytoplasm
r	0005739	cellular_component	mitochondrion
r	0005829	cellular_component	cytosol
r	0006281	biological_process	DNA repair
r	0006397	biological_process	mRNA processing
r	0008380	biological_process	RNA splicing
r	0016567	biological_process	protein ubiquitination
r	0016740	molecular_function	transferase activity
r	0042802	molecular_function	identical protein binding
r	0061630	molecular_function	ubiquitin protein ligase activity
r	0070534	biological_process	protein K63-linked ubiquitination
r	0071006	cellular_component	U2-type catalytic step 1 spliceosome
R	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
R	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
R	0000384	molecular_function	first spliceosomal transesterification activity
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005681	cellular_component	spliceosomal complex
R	0006397	biological_process	mRNA processing
R	0008380	biological_process	RNA splicing
R	0030620	molecular_function	U2 snRNA binding
R	0046872	molecular_function	metal ion binding
R	0071006	cellular_component	U2-type catalytic step 1 spliceosome
R	0071007	cellular_component	U2-type catalytic step 2 spliceosome
s	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000974	cellular_component	Prp19 complex
s	0004842	molecular_function	ubiquitin-protein transferase activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005681	cellular_component	spliceosomal complex
s	0005737	cellular_component	cytoplasm
s	0005739	cellular_component	mitochondrion
s	0005829	cellular_component	cytosol
s	0006281	biological_process	DNA repair
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0016567	biological_process	protein ubiquitination
s	0016740	molecular_function	transferase activity
s	0042802	molecular_function	identical protein binding
s	0061630	molecular_function	ubiquitin protein ligase activity
s	0070534	biological_process	protein K63-linked ubiquitination
s	0071006	cellular_component	U2-type catalytic step 1 spliceosome
S	0000348	biological_process	mRNA branch site recognition
S	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
S	0000386	molecular_function	second spliceosomal transesterification activity
S	0000389	biological_process	mRNA 3'-splice site recognition
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003729	molecular_function	mRNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005681	cellular_component	spliceosomal complex
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0034399	cellular_component	nuclear periphery
S	0071013	cellular_component	catalytic step 2 spliceosome
t	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005681	cellular_component	spliceosomal complex
t	0005737	cellular_component	cytoplasm
t	0005739	cellular_component	mitochondrion
t	0005829	cellular_component	cytosol
t	0006281	biological_process	DNA repair
t	0006397	biological_process	mRNA processing
t	0008380	biological_process	RNA splicing
t	0016567	biological_process	protein ubiquitination
t	0016740	molecular_function	transferase activity
t	0042802	molecular_function	identical protein binding
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070534	biological_process	protein K63-linked ubiquitination
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
T	0000390	biological_process	spliceosomal complex disassembly
T	0003674	molecular_function	molecular_function
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005681	cellular_component	spliceosomal complex
T	0005684	cellular_component	U2-type spliceosomal complex
T	0005737	cellular_component	cytoplasm
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
U	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
U	0000390	biological_process	spliceosomal complex disassembly
U	0000781	cellular_component	chromosome, telomeric region
U	0003676	molecular_function	nucleic acid binding
U	0003724	molecular_function	RNA helicase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005681	cellular_component	spliceosomal complex
U	0005730	cellular_component	nucleolus
U	0005737	cellular_component	cytoplasm
U	0005739	cellular_component	mitochondrion
U	0006397	biological_process	mRNA processing
U	0008380	biological_process	RNA splicing
U	0031333	biological_process	negative regulation of protein-containing complex assembly
U	0032091	biological_process	negative regulation of protein binding
U	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
U	1904876	biological_process	negative regulation of DNA ligase activity
U	2001033	biological_process	negative regulation of double-strand break repair via nonhomologous end joining
V	0000390	biological_process	spliceosomal complex disassembly
V	0003674	molecular_function	molecular_function
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005681	cellular_component	spliceosomal complex
V	0005737	cellular_component	cytoplasm
V	0005783	cellular_component	endoplasmic reticulum
V	0006397	biological_process	mRNA processing
V	0008380	biological_process	RNA splicing
V	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
W	0000390	biological_process	spliceosomal complex disassembly
W	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0003676	molecular_function	nucleic acid binding
W	0003723	molecular_function	RNA binding
W	0003724	molecular_function	RNA helicase activity
W	0003729	molecular_function	mRNA binding
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0005730	cellular_component	nucleolus
W	0005739	cellular_component	mitochondrion
W	0006364	biological_process	rRNA processing
W	0006396	biological_process	RNA processing
W	0006397	biological_process	mRNA processing
W	0008186	molecular_function	ATP-dependent activity, acting on RNA
W	0008380	biological_process	RNA splicing
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0022613	biological_process	ribonucleoprotein complex biogenesis
W	0030490	biological_process	maturation of SSU-rRNA
W	0030686	cellular_component	90S preribosome
W	0032040	cellular_component	small-subunit processome
W	0042273	biological_process	ribosomal large subunit biogenesis
W	0071014	cellular_component	post-mRNA release spliceosomal complex
W	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue IHP A 3000

Chain	Residue
A	ARG236
A	TYR1620
A	LYS517
A	HIS659
A	LYS681
A	LYS684
A	HIS685
A	TYR688
A	LYS697
A	GLY698

---

site_id	AC2
Number of Residues	16
Details	binding site for residue GTP C 1500

Chain	Residue
C	LEU142
C	HIS143
C	GLY145
C	LYS146
C	THR147
C	SER148
C	ARG176
C	SER190
C	GLY217
C	ASN268
C	LYS269
C	ASP271
C	SER315
C	THR316
C	LYS317
C	MG1501

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG C 1501

Chain	Residue
C	THR147
C	SER190
C	GTP1500

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG D 200

Chain	Residue
D	G78
D	U80

---

site_id	AC5
Number of Residues	3
Details	binding site for residue MG D 201

Chain	Residue
D	A59
D	A79
D	U80

---

site_id	AC6
Number of Residues	1
Details	binding site for residue MG D 202

Chain	Residue
D	G81

---

site_id	AC7
Number of Residues	1
Details	binding site for residue MG D 203

Chain	Residue
D	G81

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG D 204

Chain	Residue
D	C61
D	G77

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN L 1000

Chain	Residue
L	CYS104
L	CYS105
L	CYS108
L	CYS148

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN L 1001

Chain	Residue
L	CYS104
L	CYS122
L	CYS150
L	CYS153

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN L 1002

Chain	Residue
L	CYS108
L	CYS120
L	CYS122
L	CYS145

---

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN M 400

Chain	Residue
M	CYS13
M	CYS16
M	CYS71
M	CYS73
M	CYS74

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN M 401

Chain	Residue
M	CYS34
M	CYS37
M	CYS61
M	CYS64

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN N 400

Chain	Residue
N	CYS73
N	CYS81
N	CYS87
N	HIS91

---

Functional Information from PROSITE/UniProt

site_id	PS00636
Number of Residues	20
Details	DNAJ_1 Nt-dnaJ domain signature. FHlLStaTNiLtNadvRPHY

Chain	Residue	Details
T	PHE64-TYR83

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ILSGgnDhTIKIWDF

Chain	Residue	Details
S	ILE178-PHE192
O	ILE239-MET253
O	VAL281-VAL295

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScIILDEAHE

Chain	Residue	Details
W	SER210-GLU219

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqknEtNngstCiCRVP

Chain	Residue	Details
L	LEU103-PRO125

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CvHCGCRGCA

Chain	Residue	Details
L	CYS145-ALA154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
W	GLY116
R	CYS54
R	CYS88
R	CYS91

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
W	SER8
W	SER9

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
V	SER197

---