5Y6D

VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-fluorophenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 11)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046872	molecular_function	metal ion binding
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046872	molecular_function	metal ion binding
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046872	molecular_function	metal ion binding
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 301

Chain	Residue
A	ASP118
A	ARG119
A	CYS198
A	HIS240
A	ZN302
A	8PL304

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 302

Chain	Residue
A	ZN301
A	8PL304
A	HIS114
A	HIS116
A	HIS179

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 303

Chain	Residue
A	ASP78
A	HOH421
A	HOH445
A	HOH481

---

site_id	AC4
Number of Residues	14
Details	binding site for residue 8PL A 304

Chain	Residue
A	TYR67
A	TRP87
A	HIS116
A	ASP118
A	HIS179
A	ARG205
A	ASN210
A	HIS240
A	ZN301
A	ZN302
A	HOH420
A	HOH441
B	ASP63
B	GLY64

---

site_id	AC5
Number of Residues	6
Details	binding site for residue FMT A 305

Chain	Residue
A	GLU32
A	ARG127
A	THR152
A	HOH410
A	HOH433
A	HOH485

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS114
B	HIS116
B	HIS179
B	8PL303

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN B 302

Chain	Residue
B	ASP118
B	ARG119
B	CYS198
B	HIS240
B	8PL303

---

site_id	AC8
Number of Residues	14
Details	binding site for residue 8PL B 303

Chain	Residue
A	ASP63
A	GLY64
A	ALA65
B	TYR67
B	TRP87
B	ASP118
B	HIS179
B	ARG205
B	ASN210
B	HIS240
B	ZN301
B	ZN302
B	HOH429
B	HOH438

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS114
C	HIS116
C	HIS179
C	8PL303

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
C	ASP118
C	CYS198
C	HIS240
C	8PL303

---

site_id	AD2
Number of Residues	15
Details	binding site for residue 8PL C 303

Chain	Residue
C	PHE62
C	TYR67
C	TRP87
C	HIS116
C	ASP118
C	HIS179
C	ARG205
C	ASN210
C	HIS240
C	ZN301
C	ZN302
C	HOH423
C	HOH437
D	ASP63
D	GLY64

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	HIS114
D	HIS116
D	HIS179
D	8PL303

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN D 302

Chain	Residue
D	ASP118
D	ARG119
D	CYS198
D	HIS240
D	8PL303

---

site_id	AD5
Number of Residues	16
Details	binding site for residue 8PL D 303

Chain	Residue
D	ARG205
D	ASN210
D	HIS240
D	ZN301
D	ZN302
D	HOH421
D	HOH428
C	ASP63
C	GLY64
D	TYR67
D	TRP87
D	HIS114
D	HIS116
D	ASP118
D	HIS179
D	CYS198

---