5Y38

Crystal structure of C7orf59-HBXIP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0008361	biological_process	regulation of cell size
A	0009615	biological_process	response to virus
A	0010628	biological_process	positive regulation of gene expression
A	0019079	biological_process	viral genome replication
A	0031902	cellular_component	late endosome membrane
A	0032008	biological_process	positive regulation of TOR signaling
A	0032757	biological_process	positive regulation of interleukin-8 production
A	0032991	cellular_component	protein-containing complex
A	0038202	biological_process	TORC1 signaling
A	0043066	biological_process	negative regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060090	molecular_function	molecular adaptor activity
A	0061462	biological_process	protein localization to lysosome
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071986	cellular_component	Ragulator complex
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
A	1990877	cellular_component	FNIP-folliculin RagC/D GAP
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0008361	biological_process	regulation of cell size
B	0031902	cellular_component	late endosome membrane
B	0032008	biological_process	positive regulation of TOR signaling
B	0038202	biological_process	TORC1 signaling
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0060090	molecular_function	molecular adaptor activity
B	0061462	biological_process	protein localization to lysosome
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071986	cellular_component	Ragulator complex
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 201

Chain	Residue
A	SER108
A	GLN132
A	LYS160
A	GLY163

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site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 202

Chain	Residue
A	LEU111
A	ARG116
A	MET95
A	LYS96
A	ASN97
A	PRO98
A	ILE100

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site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 B 201

Chain	Residue
A	ALA135
A	THR138
A	SER139
A	ASP140
B	GLY81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
B	THR2

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31314152

Chain	Residue	Details
B	SER67

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