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5Y1U

Crystal structure of RBBP4 bound to AEBP2 RRK motif

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006260biological_processDNA replication
A0006325biological_processchromatin organization
A0006334biological_processnucleosome assembly
A0006335biological_processDNA replication-dependent chromatin assembly
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0007420biological_processbrain development
A0008094molecular_functionATP-dependent activity, acting on DNA
A0008285biological_processnegative regulation of cell population proliferation
A0016581cellular_componentNuRD complex
A0016589cellular_componentNURF complex
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031492molecular_functionnucleosomal DNA binding
A0032991cellular_componentprotein-containing complex
A0033186cellular_componentCAF-1 complex
A0035098cellular_componentESC/E(Z) complex
A0042393molecular_functionhistone binding
A0042659biological_processregulation of cell fate specification
A0042826molecular_functionhistone deacetylase binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0070822cellular_componentSin3-type complex
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A1904949cellular_componentATPase complex
A2000736biological_processregulation of stem cell differentiation
B0000118cellular_componenthistone deacetylase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006260biological_processDNA replication
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0006335biological_processDNA replication-dependent chromatin assembly
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0007420biological_processbrain development
B0008094molecular_functionATP-dependent activity, acting on DNA
B0008285biological_processnegative regulation of cell population proliferation
B0016581cellular_componentNuRD complex
B0016589cellular_componentNURF complex
B0030336biological_processnegative regulation of cell migration
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031492molecular_functionnucleosomal DNA binding
B0032991cellular_componentprotein-containing complex
B0033186cellular_componentCAF-1 complex
B0035098cellular_componentESC/E(Z) complex
B0042393molecular_functionhistone binding
B0042659biological_processregulation of cell fate specification
B0042826molecular_functionhistone deacetylase binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0070822cellular_componentSin3-type complex
B1902455biological_processnegative regulation of stem cell population maintenance
B1902459biological_processpositive regulation of stem cell population maintenance
B1904949cellular_componentATPase complex
B2000736biological_processregulation of stem cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue SO4 B 501
ChainResidue
BGLU350
BPHE352
BTHR369
BLYS407
BHOH660
BHOH750
CARG292
CARG293

site_idAC2
Number of Residues6
Detailsbinding site for residue SO4 D 101
ChainResidue
APHE352
ATHR369
ALYS407
DARG82
DARG83
AGLU350

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
ALEU224-ILE238
ALEU320-LEU334
ALEU364-LEU378

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
CSER302
DSER92

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS35
BLYS35

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER141
BSER141

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60972
ChainResidueDetails
BLYS191
ALYS191

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER386
BSER386

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS35
BLYS35

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS191
BLYS191

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PDB entries from 2024-06-12

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