5Y0V

Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with berberine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000272	biological_process	polysaccharide catabolic process
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004563	molecular_function	beta-N-acetylhexosaminidase activity
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006032	biological_process	chitin catabolic process
A	0006689	biological_process	ganglioside catabolic process
A	0008152	biological_process	metabolic process
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030203	biological_process	glycosaminoglycan metabolic process
A	0102148	molecular_function	N-acetyl-beta-D-galactosaminidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:21106526

Chain	Residue	Details
A	ASP249
A	HIS303
A	GLU368

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Important determinant of glycosidic bond specificity => ECO:0000269|PubMed:23300622

Chain	Residue	Details
A	VAL327

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Essential for chitooligosaccharide substrate binding => ECO:0000269|PubMed:23300622

Chain	Residue	Details
A	GLU328
A	TRP490

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:25155420, ECO:0000269|PubMed:30135205, ECO:0007744|PDB:3WMB, ECO:0007744|PDB:3WMC, ECO:0007744|PDB:5Y0V, ECO:0007744|PDB:5Y1B

Chain	Residue	Details
A	ASN164
A	ASN375

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