Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XXV

GDP-microtubule complexed with KIF5C in AMPPNP state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0030182	biological_process	neuron differentiation
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0030182	biological_process	neuron differentiation
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0001764	biological_process	neuron migration
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0030182	biological_process	neuron differentiation
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0001764	biological_process	neuron migration
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0030182	biological_process	neuron differentiation
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0001764	biological_process	neuron migration
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0030182	biological_process	neuron differentiation
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0001764	biological_process	neuron migration
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0030182	biological_process	neuron differentiation
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0001764	biological_process	neuron migration
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0030182	biological_process	neuron differentiation
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0001764	biological_process	neuron migration
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0007017	biological_process	microtubule-based process
O	0030182	biological_process	neuron differentiation
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0001764	biological_process	neuron migration
P	0003924	molecular_function	GTPase activity
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0030182	biological_process	neuron differentiation
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0001764	biological_process	neuron migration
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 501

Chain	Residue
A	HOH601
A	HOH602
A	HOH603
B	GTP501
B	HOH601

site_id	AC2
Number of Residues	16
Details	binding site for residue GTP B 501

Chain	Residue
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	ASN206
A	TYR224
A	ASN228
A	MG501
A	HOH601
B	LEU248
B	ASN249
B	LYS254
A	GLN11
A	ALA99
A	ASN101
A	SER140

site_id	AC3
Number of Residues	15
Details	binding site for residue GDP B 502

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	ASN101
B	GLY143
B	GLY144
B	THR145
B	GLY146
B	ASP179
B	GLU183
B	ASN206
B	TYR224
B	ASN228
I	LEU248

site_id	AC4
Number of Residues	5
Details	binding site for residue MG C 501

Chain	Residue
C	HOH601
C	HOH602
C	HOH603
D	GTP501
D	HOH601

site_id	AC5
Number of Residues	16
Details	binding site for residue GTP D 501

Chain	Residue
C	GLN11
C	ALA99
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	ASN206
C	TYR224
C	ASN228
C	MG501
C	HOH601
D	LEU248
D	ASN249
D	LYS254

site_id	AC6
Number of Residues	15
Details	binding site for residue GDP D 502

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	ASN101
D	GLY143
D	GLY144
D	THR145
D	GLY146
D	ASP179
D	GLU183
D	ASN206
D	TYR224
D	ASN228
G	LEU248

site_id	AC7
Number of Residues	5
Details	binding site for residue MG E 501

Chain	Residue
E	HOH601
E	HOH602
E	HOH603
F	GTP501
F	HOH601

site_id	AC8
Number of Residues	16
Details	binding site for residue GTP F 501

Chain	Residue
E	GLN11
E	ALA99
E	ASN101
E	SER140
E	GLY143
E	GLY144
E	THR145
E	GLY146
E	ASN206
E	TYR224
E	ASN228
E	MG501
E	HOH601
F	LEU248
F	ASN249
F	LYS254

site_id	AC9
Number of Residues	15
Details	binding site for residue GDP F 502

Chain	Residue
F	GLY144
F	THR145
F	GLY146
F	ASP179
F	GLU183
F	ASN206
F	TYR224
F	ASN228
K	LEU248
F	GLY10
F	GLN11
F	CYS12
F	GLN15
F	ASN101
F	GLY143

site_id	AD1
Number of Residues	5
Details	binding site for residue MG G 501

Chain	Residue
G	HOH601
G	HOH602
G	HOH603
H	GTP501
H	HOH601

site_id	AD2
Number of Residues	14
Details	binding site for residue GDP H 502

Chain	Residue
H	GLY10
H	GLN11
H	CYS12
H	GLN15
H	ASN101
H	GLY143
H	GLY144
H	THR145
H	GLY146
H	ASP179
H	GLU183
H	ASN206
H	TYR224
H	ASN228

site_id	AD3
Number of Residues	5
Details	binding site for residue MG I 501

Chain	Residue
I	HOH601
I	HOH602
I	HOH603
J	GTP501
J	HOH601

site_id	AD4
Number of Residues	14
Details	binding site for residue GDP J 502

Chain	Residue
J	GLY10
J	GLN11
J	CYS12
J	GLN15
J	ASN101
J	GLY143
J	GLY144
J	THR145
J	GLY146
J	ASP179
J	GLU183
J	ASN206
J	TYR224
J	ASN228

site_id	AD5
Number of Residues	5
Details	binding site for residue MG K 501

Chain	Residue
K	HOH601
K	HOH602
K	HOH603
L	GTP501
L	HOH601

site_id	AD6
Number of Residues	14
Details	binding site for residue GDP L 502

Chain	Residue
L	GLY10
L	GLN11
L	CYS12
L	GLN15
L	ASN101
L	GLY143
L	GLY144
L	THR145
L	GLY146
L	ASP179
L	GLU183
L	ASN206
L	TYR224
L	ASN228

site_id	AD7
Number of Residues	5
Details	binding site for residue MG M 501

Chain	Residue
M	HOH601
M	HOH602
M	HOH603
N	GTP501
N	HOH601

site_id	AD8
Number of Residues	15
Details	binding site for residue GDP N 502

Chain	Residue
C	LEU248
N	GLY10
N	GLN11
N	CYS12
N	GLN15
N	ASN101
N	GLY143
N	GLY144
N	THR145
N	GLY146
N	ASP179
N	GLU183
N	ASN206
N	TYR224
N	ASN228

site_id	AD9
Number of Residues	5
Details	binding site for residue MG O 501

Chain	Residue
O	HOH601
O	HOH602
O	HOH603
P	GTP501
P	HOH601

site_id	AE1
Number of Residues	15
Details	binding site for residue GDP P 502

Chain	Residue
A	LEU248
P	GLY10
P	GLN11
P	CYS12
P	GLN15
P	ASN101
P	GLY143
P	GLY144
P	THR145
P	GLY146
P	ASP179
P	GLU183
P	ASN206
P	TYR224
P	ASN228

site_id	AE2
Number of Residues	5
Details	binding site for residue MG Q 501

Chain	Residue
Q	HOH601
Q	HOH602
Q	HOH603
R	GTP501
R	HOH601

site_id	AE3
Number of Residues	15
Details	binding site for residue GDP R 502

Chain	Residue
E	LEU248
R	GLY10
R	GLN11
R	CYS12
R	GLN15
R	ASN101
R	GLY143
R	GLY144
R	THR145
R	GLY146
R	ASP179
R	GLU183
R	ASN206
R	TYR224
R	ASN228

site_id	AE4
Number of Residues	8
Details	binding site for Ligand GLN I 133 bound to SER B 97

Chain	Residue
B	GLN96
B	SER97
I	ARG2
I	GLU3
I	GLY131
I	LEU132
I	GLY134
I	SER165

site_id	AE5
Number of Residues	8
Details	binding site for Ligand GLN G 133 bound to SER D 97

Chain	Residue
D	GLN96
D	SER97
G	ARG2
G	GLU3
G	GLY131
G	LEU132
G	GLY134
G	SER165

site_id	AE6
Number of Residues	8
Details	binding site for Ligand GLN K 133 bound to SER F 97

Chain	Residue
F	GLN96
F	SER97
K	ARG2
K	GLU3
K	GLY131
K	LEU132
K	GLY134
K	SER165

site_id	AE7
Number of Residues	6
Details	binding site for Ligand THR H 353 bound to THR G 179

Chain	Residue
G	THR179
H	LEU248
H	ASN249
H	ALA317
H	LYS352
H	ALA354

site_id	AE8
Number of Residues	6
Details	binding site for Ligand THR J 353 bound to THR I 179

Chain	Residue
I	THR179
J	LEU248
J	ASN249
J	ALA317
J	LYS352
J	ALA354

site_id	AE9
Number of Residues	6
Details	binding site for Ligand THR L 353 bound to THR K 179

Chain	Residue
K	THR179
L	LEU248
L	ASN249
L	ALA317
L	LYS352
L	ALA354

site_id	AF1
Number of Residues	6
Details	binding site for Ligand THR N 353 bound to THR M 179

Chain	Residue
M	THR179
N	LEU248
N	ASN249
N	ALA317
N	LYS352
N	ALA354

site_id	AF2
Number of Residues	8
Details	binding site for Ligand GLN C 133 bound to SER N 97

Chain	Residue
C	ARG2
C	GLU3
C	GLY131
C	LEU132
C	GLY134
C	SER165
N	GLN96
N	SER97

site_id	AF3
Number of Residues	6
Details	binding site for Ligand THR P 353 bound to THR O 179

Chain	Residue
O	THR179
P	LEU248
P	ASN249
P	ALA317
P	LYS352
P	ALA354

site_id	AF4
Number of Residues	8
Details	binding site for Ligand GLN A 133 bound to SER P 97

Chain	Residue
A	ARG2
A	GLU3
A	GLY131
A	LEU132
A	GLY134
A	SER165
P	GLN96
P	SER97

site_id	AF5
Number of Residues	6
Details	binding site for Ligand THR R 353 bound to THR Q 179

Chain	Residue
Q	THR179
R	LEU248
R	ASN249
R	ALA317
R	LYS352
R	ALA354

site_id	AF6
Number of Residues	8
Details	binding site for Ligand GLN E 133 bound to SER R 97

Chain	Residue
E	ARG2
E	GLU3
E	GLY131
E	LEU132
E	GLY134
E	SER165
R	GLN96
R	SER97

site_id	AF7
Number of Residues	32
Details	binding site for Di-peptide TYR C 224 and MET D 325

Chain	Residue
C	ASN206
C	TYR210
C	PRO222
C	THR223
C	THR225
C	ASN226
C	LEU227
C	ASN228
C	VAL323
C	VAL324
C	LYS326
C	ASP327
C	VAL328
C	ASN329
D	TYR210
D	THR223
D	GLY225
D	ASP226
D	LEU227
D	ASN228
D	GLN247
D	MET323
D	SER324
D	LYS326
D	GLU327
D	VAL328
D	ASP329
D	GTP501
D	GDP502
G	PRO325
N	TYR210
N	TYR224

site_id	AF8
Number of Residues	32
Details	binding site for Di-peptide TYR E 224 and MET F 325

Chain	Residue
E	ASN206
E	TYR210
E	PRO222
E	THR223
E	THR225
E	ASN226
E	LEU227
E	ASN228
E	VAL323
E	VAL324
E	LYS326
E	ASP327
E	VAL328
E	ASN329
F	TYR210
F	THR223
F	GLY225
F	ASP226
F	LEU227
F	ASN228
F	GLN247
F	MET323
F	SER324
F	LYS326
F	GLU327
F	VAL328
F	ASP329
F	GTP501
F	GDP502
K	PRO325
R	TYR210
R	TYR224

site_id	AF9
Number of Residues	26
Details	binding site for Di-peptide GLN G 176 and LEU H 333

Chain	Residue
D	LYS176
G	ALA174
G	PRO175
G	VAL177
G	GLU207
G	ASN329
G	ALA330
G	ALA331
G	ILE332
G	THR334
G	ILE335
G	LYS336
G	THR337
H	SER174
H	PRO175
H	VAL177
H	SER178
H	GLU207
H	ASP329
H	GLU330
H	GLN331
H	MET332
H	ASN334
H	VAL335
H	GLN336
H	ASN337

site_id	AG1
Number of Residues	31
Details	binding site for Di-peptide TYR G 224 and MET H 325

Chain	Residue
D	TYR210
D	TYR224
G	ASN206
G	TYR210
G	PRO222
G	THR223
G	THR225
G	ASN226
G	LEU227
G	ASN228
G	VAL323
G	VAL324
G	LYS326
G	ASP327
G	VAL328
G	ASN329
H	TYR210
H	THR223
H	GLY225
H	ASP226
H	LEU227
H	ASN228
H	GLN247
H	MET323
H	SER324
H	LYS326
H	GLU327
H	VAL328
H	ASP329
H	GTP501
H	GDP502

site_id	AG2
Number of Residues	23
Details	binding site for Di-peptide GTP H 501 and LYS H 254

Chain	Residue
G	GLN11
G	ALA99
G	ALA100
G	ASN101
G	SER140
G	GLY143
G	GLY144
G	THR145
G	GLY146
G	ASN206
G	TYR224
G	ASN228
G	MG501
G	HOH601
H	LEU248
H	ASN249
H	ASP251
H	LEU252
H	ARG253
H	LEU255
H	ALA256
H	VAL257
H	ASN258

site_id	AG3
Number of Residues	26
Details	binding site for Di-peptide GLN I 176 and LEU J 333

Chain	Residue
B	LYS176
I	ALA174
I	PRO175
I	VAL177
I	GLU207
I	ASN329
I	ALA330
I	ALA331
I	ILE332
I	THR334
I	ILE335
I	LYS336
I	THR337
J	SER174
J	PRO175
J	VAL177
J	SER178
J	GLU207
J	ASP329
J	GLU330
J	GLN331
J	MET332
J	ASN334
J	VAL335
J	GLN336
J	ASN337

site_id	AG4
Number of Residues	31
Details	binding site for Di-peptide TYR I 224 and MET J 325

Chain	Residue
B	TYR210
B	TYR224
I	ASN206
I	TYR210
I	PRO222
I	THR223
I	THR225
I	ASN226
I	LEU227
I	ASN228
I	VAL323
I	VAL324
I	LYS326
I	ASP327
I	VAL328
I	ASN329
J	TYR210
J	THR223
J	GLY225
J	ASP226
J	LEU227
J	ASN228
J	GLN247
J	MET323
J	SER324
J	LYS326
J	GLU327
J	VAL328
J	ASP329
J	GTP501
J	GDP502

site_id	AG5
Number of Residues	23
Details	binding site for Di-peptide ARG J 48 and ASP I 76

Chain	Residue
I	PRO72
I	THR73
I	VAL74
I	ILE75
I	GLU77
I	VAL78
I	ARG79
I	THR80
J	LEU42
J	LEU44
J	GLU47
J	ILE49
J	ASN50
J	VAL51
J	PRO72
J	GLY73
J	THR74
J	MET75
J	SER77
J	VAL78
J	ARG79
J	SER80
J	ARG243

site_id	AG6
Number of Residues	23
Details	binding site for Di-peptide GTP J 501 and LYS J 254

Chain	Residue
I	GLN11
I	ALA99
I	ALA100
I	ASN101
I	SER140
I	GLY143
I	GLY144
I	THR145
I	GLY146
I	ASN206
I	TYR224
I	ASN228
I	MG501
I	HOH601
J	LEU248
J	ASN249
J	ASP251
J	LEU252
J	ARG253
J	LEU255
J	ALA256
J	VAL257
J	ASN258

site_id	AG7
Number of Residues	26
Details	binding site for Di-peptide GLN K 11 and GLN L 247

Chain	Residue
F	GLN11
F	GLN15
K	GLY10
K	ALA12
K	GLY13
K	VAL14
K	GLN15
K	VAL74
K	TYR224
K	GLY246
K	LEU248
K	ILE355
K	TYR357
K	HOH601
L	GLY10
L	CYS12
L	GLY13
L	ASN14
L	GLN15
L	GLY246
L	LEU248
L	ASN249
L	VAL355
L	ASP357
L	GTP501
L	GDP502

site_id	AG8
Number of Residues	31
Details	binding site for Di-peptide TYR K 224 and MET L 325

Chain	Residue
F	TYR210
F	TYR224
K	ASN206
K	TYR210
K	PRO222
K	THR223
K	THR225
K	ASN226
K	LEU227
K	ASN228
K	VAL323
K	VAL324
K	LYS326
K	ASP327
K	VAL328
K	ASN329
L	TYR210
L	THR223
L	GLY225
L	ASP226
L	LEU227
L	ASN228
L	GLN247
L	MET323
L	SER324
L	LYS326
L	GLU327
L	VAL328
L	ASP329
L	GTP501
L	GDP502

site_id	AG9
Number of Residues	23
Details	binding site for Di-peptide GTP L 501 and LYS L 254

Chain	Residue
K	GLN11
K	ALA99
K	ALA100
K	ASN101
K	SER140
K	GLY143
K	GLY144
K	THR145
K	GLY146
K	ASN206
K	TYR224
K	ASN228
K	MG501
K	HOH601
L	LEU248
L	ASN249
L	ASP251
L	LEU252
L	ARG253
L	LEU255
L	ALA256
L	VAL257
L	ASN258

site_id	AH1
Number of Residues	32
Details	binding site for Di-peptide VAL M 181 and LYS N 352

Chain	Residue
C	CYS347
C	PRO348
C	GLY350
M	SER178
M	THR179
M	ALA180
M	VAL182
M	GLU183
M	VAL250
M	GLU254
M	ASN258
M	CYS315
M	CYS316
M	LEU317
M	GLY350
M	PHE351
M	VAL353
M	MET398
M	PHE404
N	THR180
N	VAL182
N	GLU183
N	ASN258
N	VAL315
N	ALA316
N	ALA317
N	ILE347
N	ASN349
N	VAL351
N	THR353
N	MET398
N	PHE404

site_id	AH2
Number of Residues	30
Details	binding site for Di-peptide TYR M 224 and MET N 325

Chain	Residue
C	PRO325
M	ASN206
M	TYR210
M	PRO222
M	THR223
M	THR225
M	ASN226
M	LEU227
M	ASN228
M	VAL323
M	VAL324
M	LYS326
M	ASP327
M	VAL328
M	ASN329
N	TYR210
N	THR223
N	GLY225
N	ASP226
N	LEU227
N	ASN228
N	GLN247
N	MET323
N	SER324
N	LYS326
N	GLU327
N	VAL328
N	ASP329
N	GTP501
N	GDP502

site_id	AH3
Number of Residues	22
Details	binding site for Di-peptide ARG N 2 and GLU M 97

Chain	Residue
C	GLN133
C	THR253
M	GLU3
M	THR51
M	LEU70
M	GLU71
M	LYS96
M	ASP98
M	ILE110
M	GLY131
M	GLN133
N	GLU3
N	VAL51
N	LEU70
N	GLN96
N	GLY98
N	LYS105
N	GLU110
N	CYS131
N	GLN133
N	ASP251
N	ARG253

site_id	AH4
Number of Residues	22
Details	binding site for Di-peptide ARG N 2 and GLU M 97

Chain	Residue
C	GLN133
C	THR253
M	GLU3
M	THR51
M	LEU70
M	GLU71
M	LYS96
M	ASP98
M	ILE110
M	GLY131
M	GLN133
N	GLU3
N	VAL51
N	LEU70
N	GLN96
N	GLY98
N	LYS105
N	GLU110
N	CYS131
N	GLN133
N	ASP251
N	ARG253

site_id	AH5
Number of Residues	24
Details	binding site for Di-peptide ARG N 48 and ASP M 76

Chain	Residue
C	ARG2
M	PRO72
M	THR73
M	VAL74
M	ILE75
M	GLU77
M	VAL78
M	ARG79
M	THR80
N	LEU42
N	LEU44
N	GLU47
N	ILE49
N	ASN50
N	VAL51
N	PRO72
N	GLY73
N	THR74
N	MET75
N	SER77
N	VAL78
N	ARG79
N	SER80
N	ARG243

site_id	AH6
Number of Residues	24
Details	binding site for Di-peptide GTP N 501 and LYS N 254

Chain	Residue
M	GLN11
M	ALA99
M	ALA100
M	ASN101
M	SER140
M	GLY143
M	GLY144
M	THR145
M	GLY146
M	ASN206
M	TYR224
M	ASN228
M	MG501
M	HOH601
N	GLN247
N	LEU248
N	ASN249
N	ASP251
N	LEU252
N	ARG253
N	LEU255
N	ALA256
N	VAL257
N	ASN258

site_id	AH7
Number of Residues	32
Details	binding site for Di-peptide VAL O 181 and LYS P 352

Chain	Residue
A	CYS347
A	PRO348
A	GLY350
O	SER178
O	THR179
O	ALA180
O	VAL182
O	GLU183
O	VAL250
O	GLU254
O	ASN258
O	CYS315
O	CYS316
O	LEU317
O	GLY350
O	PHE351
O	VAL353
O	MET398
O	PHE404
P	THR180
P	VAL182
P	GLU183
P	ASN258
P	VAL315
P	ALA316
P	ALA317
P	ILE347
P	ASN349
P	VAL351
P	THR353
P	MET398
P	PHE404

site_id	AH8
Number of Residues	30
Details	binding site for Di-peptide TYR O 224 and MET P 325

Chain	Residue
A	PRO325
O	ASN206
O	TYR210
O	PRO222
O	THR223
O	THR225
O	ASN226
O	LEU227
O	ASN228
O	VAL323
O	VAL324
O	LYS326
O	ASP327
O	VAL328
O	ASN329
P	TYR210
P	THR223
P	GLY225
P	ASP226
P	LEU227
P	ASN228
P	GLN247
P	MET323
P	SER324
P	LYS326
P	GLU327
P	VAL328
P	ASP329
P	GTP501
P	GDP502

site_id	AH9
Number of Residues	21
Details	binding site for Di-peptide ARG P 2 and GLU O 97

Chain	Residue
A	GLN133
O	GLU3
O	THR51
O	LEU70
O	GLU71
O	LYS96
O	ASP98
O	ILE110
O	GLY131
O	GLN133
P	GLU3
P	VAL51
P	LEU70
P	GLN96
P	GLY98
P	LYS105
P	GLU110
P	CYS131
P	GLN133
P	ASP251
P	ARG253

site_id	AI1
Number of Residues	21
Details	binding site for Di-peptide ARG P 2 and GLU O 97

Chain	Residue
A	GLN133
O	GLU3
O	THR51
O	LEU70
O	GLU71
O	LYS96
O	ASP98
O	ILE110
O	GLY131
O	GLN133
P	GLU3
P	VAL51
P	LEU70
P	GLN96
P	GLY98
P	LYS105
P	GLU110
P	CYS131
P	GLN133
P	ASP251
P	ARG253

site_id	AI2
Number of Residues	24
Details	binding site for Di-peptide ARG P 48 and ASP O 76

Chain	Residue
A	ARG2
O	PRO72
O	THR73
O	VAL74
O	ILE75
O	GLU77
O	VAL78
O	ARG79
O	THR80
P	LEU42
P	LEU44
P	GLU47
P	ILE49
P	ASN50
P	VAL51
P	PRO72
P	GLY73
P	THR74
P	MET75
P	SER77
P	VAL78
P	ARG79
P	SER80
P	ARG243

site_id	AI3
Number of Residues	24
Details	binding site for Di-peptide GTP P 501 and LYS P 254

Chain	Residue
O	GLN11
O	ALA99
O	ALA100
O	ASN101
O	SER140
O	GLY143
O	GLY144
O	THR145
O	GLY146
O	ASN206
O	TYR224
O	ASN228
O	MG501
O	HOH601
P	GLN247
P	LEU248
P	ASN249
P	ASP251
P	LEU252
P	ARG253
P	LEU255
P	ALA256
P	VAL257
P	ASN258

site_id	AI4
Number of Residues	32
Details	binding site for Di-peptide VAL Q 181 and LYS R 352

Chain	Residue
E	CYS347
E	PRO348
E	GLY350
Q	SER178
Q	THR179
Q	ALA180
Q	VAL182
Q	GLU183
Q	VAL250
Q	GLU254
Q	ASN258
Q	CYS315
Q	CYS316
Q	LEU317
Q	GLY350
Q	PHE351
Q	VAL353
Q	MET398
Q	PHE404
R	THR180
R	VAL182
R	GLU183
R	ASN258
R	VAL315
R	ALA316
R	ALA317
R	ILE347
R	ASN349
R	VAL351
R	THR353
R	MET398
R	PHE404

site_id	AI5
Number of Residues	30
Details	binding site for Di-peptide TYR Q 224 and MET R 325

Chain	Residue
R	GLU327
R	VAL328
R	ASP329
R	GTP501
R	GDP502
E	PRO325
Q	ASN206
Q	TYR210
Q	PRO222
Q	THR223
Q	THR225
Q	ASN226
Q	LEU227
Q	ASN228
Q	VAL323
Q	VAL324
Q	LYS326
Q	ASP327
Q	VAL328
Q	ASN329
R	TYR210
R	THR223
R	GLY225
R	ASP226
R	LEU227
R	ASN228
R	GLN247
R	MET323
R	SER324
R	LYS326

site_id	AI6
Number of Residues	22
Details	binding site for Di-peptide ARG R 2 and GLU Q 97

Chain	Residue
E	GLN133
E	THR253
Q	GLU3
Q	THR51
Q	LEU70
Q	GLU71
Q	LYS96
Q	ASP98
Q	ILE110
Q	GLY131
Q	GLN133
R	GLU3
R	VAL51
R	LEU70
R	GLN96
R	GLY98
R	LYS105
R	GLU110
R	CYS131
R	GLN133
R	ASP251
R	ARG253

site_id	AI7
Number of Residues	22
Details	binding site for Di-peptide ARG R 2 and GLU Q 97

Chain	Residue
E	GLN133
E	THR253
Q	GLU3
Q	THR51
Q	LEU70
Q	GLU71
Q	LYS96
Q	ASP98
Q	ILE110
Q	GLY131
Q	GLN133
R	GLU3
R	VAL51
R	LEU70
R	GLN96
R	GLY98
R	LYS105
R	GLU110
R	CYS131
R	GLN133
R	ASP251
R	ARG253

site_id	AI8
Number of Residues	24
Details	binding site for Di-peptide ARG R 48 and ASP Q 76

Chain	Residue
E	ARG2
Q	PRO72
Q	THR73
Q	VAL74
Q	ILE75
Q	GLU77
Q	VAL78
Q	ARG79
Q	THR80
R	LEU42
R	LEU44
R	GLU47
R	ILE49
R	ASN50
R	VAL51
R	PRO72
R	GLY73
R	THR74
R	MET75
R	SER77
R	VAL78
R	ARG79
R	SER80
R	ARG243

site_id	AI9
Number of Residues	23
Details	binding site for Di-peptide GTP R 501 and LYS R 254

Chain	Residue
Q	GLN11
Q	ALA99
Q	ALA100
Q	ASN101
Q	SER140
Q	GLY143
Q	GLY144
Q	THR145
Q	GLY146
Q	ASN206
Q	TYR224
Q	ASN228
Q	MG501
Q	HOH601
R	LEU248
R	ASN249
R	ASP251
R	LEU252
R	ARG253
R	LEU255
R	ALA256
R	VAL257
R	ASN258

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY142-GLY148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	162
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	63
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	9
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	18
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	9
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	18
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)