5XWM
human ERp44 zinc-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003756 | molecular_function | protein disulfide isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| A | 0006457 | biological_process | protein folding |
| A | 0006986 | biological_process | response to unfolded protein |
| A | 0009100 | biological_process | glycoprotein metabolic process |
| A | 0009986 | cellular_component | cell surface |
| A | 0034976 | biological_process | response to endoplasmic reticulum stress |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003756 | molecular_function | protein disulfide isomerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| B | 0006457 | biological_process | protein folding |
| B | 0006986 | biological_process | response to unfolded protein |
| B | 0009100 | biological_process | glycoprotein metabolic process |
| B | 0009986 | cellular_component | cell surface |
| B | 0034976 | biological_process | response to endoplasmic reticulum stress |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0003756 | molecular_function | protein disulfide isomerase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| C | 0006457 | biological_process | protein folding |
| C | 0006986 | biological_process | response to unfolded protein |
| C | 0009100 | biological_process | glycoprotein metabolic process |
| C | 0009986 | cellular_component | cell surface |
| C | 0034976 | biological_process | response to endoplasmic reticulum stress |
| C | 0035580 | cellular_component | specific granule lumen |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0003756 | molecular_function | protein disulfide isomerase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005788 | cellular_component | endoplasmic reticulum lumen |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| D | 0006457 | biological_process | protein folding |
| D | 0006986 | biological_process | response to unfolded protein |
| D | 0009100 | biological_process | glycoprotein metabolic process |
| D | 0009986 | cellular_component | cell surface |
| D | 0034976 | biological_process | response to endoplasmic reticulum stress |
| D | 0035580 | cellular_component | specific granule lumen |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS29 |
| A | TYR78 |
| A | CL404 |
| C | HIS333 |
| C | CL403 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | HIS277 |
| A | HIS281 |
| C | HIS277 |
| C | HIS281 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 403 |
| Chain | Residue |
| A | HIS299 |
| A | HIS328 |
| A | HIS332 |
| A | HOH533 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | TYR78 |
| A | ZN401 |
| C | CL403 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | ARG329 |
| C | TRP28 |
| C | ZN402 |
| C | CL404 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | HIS277 |
| B | HIS281 |
| D | HIS277 |
| D | HIS281 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | HIS299 |
| B | HIS328 |
| B | HIS332 |
| B | HOH618 |
| B | HOH621 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| B | CYS29 |
| B | TYR78 |
| B | CL405 |
| D | HIS333 |
| D | CL404 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 404 |
| Chain | Residue |
| B | ARG329 |
| D | ZN401 |
| D | CL403 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | TYR78 |
| B | ZN403 |
| D | CL404 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 401 |
| Chain | Residue |
| C | HIS299 |
| C | HIS328 |
| C | HIS332 |
| C | HOH629 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 402 |
| Chain | Residue |
| A | HIS333 |
| A | CL405 |
| C | CYS29 |
| C | TYR78 |
| C | CL404 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 403 |
| Chain | Residue |
| A | ZN401 |
| A | CL404 |
| C | ARG329 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 404 |
| Chain | Residue |
| A | CL405 |
| C | TRP28 |
| C | TYR78 |
| C | ZN402 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 401 |
| Chain | Residue |
| B | HIS333 |
| B | CL404 |
| D | CYS29 |
| D | TYR78 |
| D | CL403 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 402 |
| Chain | Residue |
| D | HIS299 |
| D | HIS328 |
| D | HIS332 |
| D | HOH639 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 403 |
| Chain | Residue |
| B | CL404 |
| D | ZN401 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 404 |
| Chain | Residue |
| B | ZN403 |
| B | CL405 |
| D | ARG329 |
| D | HIS333 |
Functional Information from PROSITE/UniProt
| site_id | PS00014 |
| Number of Residues | 4 |
| Details | ER_TARGET Endoplasmic reticulum targeting sequence. RDEL |
| Chain | Residue | Details |
| A | ARG374-LEU377 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 324 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 196 |
| Details | Region: {"description":"Interaction with ITPR1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Prevents secretion from ER","evidences":[{"source":"PROSITE-ProRule","id":"PRU10138","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
