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5XUQ

Crystal structure of VDR-LBD complexed with an antagonist, 2-methylidene-19,26,27-trinor-22-(S)-butyl-1-hydroxy-25-oxo-25-(1H-pyrrol-2-yl)- vitamin D3

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 8FF A 501
ChainResidue
ATYR143
ACYS284
AHIS301
ALEU309
AHIS393
APHE418
ALEU223
AVAL230
ASER233
AMET268
AARG270
ASER271
ASER274
ATRP282

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsRegion: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RK3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 2"}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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