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5XUJ

Crystal structure of PDE10A in complex with 7-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN A 801
ChainResidue
AHIS529
AHIS563
AASP564
AASP674
AHOH908
AHOH931

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 802
ChainResidue
AHOH908
AHOH925
AASP564
AHOH905
AHOH906

site_idAC3
Number of Residues4
Detailsbinding site for residue 8G6 A 803
ChainResidue
ATYR524
ALEU635
AGLN726
APHE729

site_idAC4
Number of Residues7
Detailsbinding site for residue ZN B 801
ChainResidue
BHIS529
BHIS563
BASP564
BASP674
BMG802
BHOH906
BHOH941

site_idAC5
Number of Residues7
Detailsbinding site for residue MG B 802
ChainResidue
BASP564
BZN801
BHOH901
BHOH906
BHOH927
BHOH933
BHOH934

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS563-TYR574

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
AGLY640
AGLN659
BCYS562
BGLU606
BGLY640
BGLN659
ACYS562
AGLU606

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PDB entries from 2024-06-12

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