5XTL

Crystal Structure of Transketolase in complex with aminopyrimidine and cysteine sulfonic acid adduct from Pichia Stipitis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004802	molecular_function	transketolase activity
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006098	biological_process	pentose-phosphate shunt

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue P23 A 701

Chain	Residue
A	ALA30
A	ILE187
A	SER188
A	ILE248
A	HIS261
A	CA702
A	HOH957
A	HOH1017
A	ASN64
A	HIS66
A	LEU116
A	GLY154
A	ASP155
A	GLY156
A	OCS157
A	ASN185

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 702

Chain	Residue
A	ASP155
A	ASN185
A	ILE187
A	P23701
A	HOH957

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PEG A 703

Chain	Residue
A	ALA134
A	ASN138
A	HOH1033

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PEG A 704

Chain	Residue
A	ASN310
A	HOH1387

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PEG A 705

Chain	Residue
A	THR198
A	LYS206
A	SER207
A	HOH892
A	HOH937

---

site_id	AC6
Number of Residues	8
Details	binding site for residue 8GF A 706

Chain	Residue
A	GLY114
A	PRO115
A	LEU116
A	GLU160
A	GLU415
A	PHE442
A	TYR445
A	HIS478

---

Functional Information from PROSITE/UniProt

site_id	PS00801
Number of Residues	21
Details	TRANSKETOLASE_1 Transketolase signature 1. RllaVDavaaanSGHPGapLG

Chain	Residue	Details
A	ARG13-GLY33

---

site_id	PS00802
Number of Residues	17
Details	TRANSKETOLASE_2 Transketolase signature 2. GEDGPTHqPIEtlAhfR

Chain	Residue	Details
A	GLY472-ARG488

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5I5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XQK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29243887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HYV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XPS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XRV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XU2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29243887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HYV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XPS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XS6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XPS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29243887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HYV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XPS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XRV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XU2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XPS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29243887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30155962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XRV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XS6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HYV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XPS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XQA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I51","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"27578891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---