Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XTI

Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0005751	cellular_component	mitochondrial respiratory chain complex IV
0	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
1	0005743	cellular_component	mitochondrial inner membrane
1	0005751	cellular_component	mitochondrial respiratory chain complex IV
1	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
2	0005740	cellular_component	mitochondrial envelope
2	0005751	cellular_component	mitochondrial respiratory chain complex IV
2	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
3	0005743	cellular_component	mitochondrial inner membrane
3	0005751	cellular_component	mitochondrial respiratory chain complex IV
4	0005739	cellular_component	mitochondrion
4	0045277	cellular_component	respiratory chain complex IV
5	0005739	cellular_component	mitochondrion
5	0005743	cellular_component	mitochondrial inner membrane
5	0006119	biological_process	oxidative phosphorylation
5	0045277	cellular_component	respiratory chain complex IV
6	0005746	cellular_component	mitochondrial respirasome
6	0005751	cellular_component	mitochondrial respiratory chain complex IV
6	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
7	0005746	cellular_component	mitochondrial respirasome
7	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
8	0005751	cellular_component	mitochondrial respiratory chain complex IV
8	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
9	0005751	cellular_component	mitochondrial respiratory chain complex IV
9	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A	0005829	cellular_component	cytosol
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0009060	biological_process	aerobic respiration
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0045271	cellular_component	respiratory chain complex I
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
AA	0005739	cellular_component	mitochondrion
AA	0005743	cellular_component	mitochondrial inner membrane
AA	0005750	cellular_component	mitochondrial respiratory chain complex III
AA	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AA	0021539	biological_process	subthalamus development
AA	0021548	biological_process	pons development
AA	0021680	biological_process	cerebellar Purkinje cell layer development
AA	0021766	biological_process	hippocampus development
AA	0021794	biological_process	thalamus development
AA	0021854	biological_process	hypothalamus development
AA	0021860	biological_process	pyramidal neuron development
AA	0030901	biological_process	midbrain development
AA	0045333	biological_process	cellular respiration
AA	0070469	cellular_component	respirasome
AB	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AC	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AC	0016020	cellular_component	membrane
AC	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AD	0005515	molecular_function	protein binding
AD	0005739	cellular_component	mitochondrion
AD	0005743	cellular_component	mitochondrial inner membrane
AD	0005750	cellular_component	mitochondrial respiratory chain complex III
AD	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AD	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AD	0045333	biological_process	cellular respiration
AD	0070469	cellular_component	respirasome
AD	1902600	biological_process	proton transmembrane transport
AE	0005750	cellular_component	mitochondrial respiratory chain complex III
AE	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AF	0005515	molecular_function	protein binding
AF	0005739	cellular_component	mitochondrion
AF	0005743	cellular_component	mitochondrial inner membrane
AF	0005746	cellular_component	mitochondrial respirasome
AF	0005750	cellular_component	mitochondrial respiratory chain complex III
AF	0006119	biological_process	oxidative phosphorylation
AF	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AF	0009060	biological_process	aerobic respiration
AF	0045333	biological_process	cellular respiration
AF	0070469	cellular_component	respirasome
AG	0005739	cellular_component	mitochondrion
AG	0005743	cellular_component	mitochondrial inner membrane
AG	0005750	cellular_component	mitochondrial respiratory chain complex III
AG	0006091	biological_process	generation of precursor metabolites and energy
AG	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AG	0009055	molecular_function	electron transfer activity
AG	0045333	biological_process	cellular respiration
AG	0070469	cellular_component	respirasome
AH	0009055	molecular_function	electron transfer activity
AH	0020037	molecular_function	heme binding
AJ	0001666	biological_process	response to hypoxia
AJ	0005739	cellular_component	mitochondrion
AJ	0005743	cellular_component	mitochondrial inner membrane
AJ	0005750	cellular_component	mitochondrial respiratory chain complex III
AJ	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AJ	0007584	biological_process	response to nutrient
AJ	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AJ	0009055	molecular_function	electron transfer activity
AJ	0009410	biological_process	response to xenobiotic stimulus
AJ	0009636	biological_process	response to toxic substance
AJ	0009725	biological_process	response to hormone
AJ	0010243	biological_process	response to organonitrogen compound
AJ	0014070	biological_process	response to organic cyclic compound
AJ	0015990	biological_process	electron transport coupled proton transport
AJ	0016020	cellular_component	membrane
AJ	0016491	molecular_function	oxidoreductase activity
AJ	0022904	biological_process	respiratory electron transport chain
AJ	0031100	biological_process	animal organ regeneration
AJ	0032991	cellular_component	protein-containing complex
AJ	0033590	biological_process	response to cobalamin
AJ	0033762	biological_process	response to glucagon
AJ	0044877	molecular_function	protein-containing complex binding
AJ	0045275	cellular_component	respiratory chain complex III
AJ	0045333	biological_process	cellular respiration
AJ	0045471	biological_process	response to ethanol
AJ	0046686	biological_process	response to cadmium ion
AJ	0046688	biological_process	response to copper ion
AJ	0046689	biological_process	response to mercury ion
AJ	0046872	molecular_function	metal ion binding
AJ	0051592	biological_process	response to calcium ion
AJ	0055093	biological_process	response to hyperoxia
AJ	0070469	cellular_component	respirasome
AK	0004222	molecular_function	metalloendopeptidase activity
AK	0005515	molecular_function	protein binding
AK	0005654	cellular_component	nucleoplasm
AK	0005739	cellular_component	mitochondrion
AK	0005743	cellular_component	mitochondrial inner membrane
AK	0005750	cellular_component	mitochondrial respiratory chain complex III
AK	0006119	biological_process	oxidative phosphorylation
AK	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AK	0006508	biological_process	proteolysis
AK	0009060	biological_process	aerobic respiration
AK	0045275	cellular_component	respiratory chain complex III
AK	0045333	biological_process	cellular respiration
AK	0046872	molecular_function	metal ion binding
AK	0070469	cellular_component	respirasome
AL	0005515	molecular_function	protein binding
AL	0005739	cellular_component	mitochondrion
AL	0005743	cellular_component	mitochondrial inner membrane
AL	0005746	cellular_component	mitochondrial respirasome
AL	0005750	cellular_component	mitochondrial respiratory chain complex III
AL	0006119	biological_process	oxidative phosphorylation
AL	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AL	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AL	0009060	biological_process	aerobic respiration
AL	0014823	biological_process	response to activity
AL	0031625	molecular_function	ubiquitin protein ligase binding
AL	0043279	biological_process	response to alkaloid
AL	0044877	molecular_function	protein-containing complex binding
AL	0045333	biological_process	cellular respiration
AL	0046872	molecular_function	metal ion binding
AL	0070469	cellular_component	respirasome
AL	1902600	biological_process	proton transmembrane transport
AN	0005739	cellular_component	mitochondrion
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0005750	cellular_component	mitochondrial respiratory chain complex III
AN	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AN	0021539	biological_process	subthalamus development
AN	0021548	biological_process	pons development
AN	0021680	biological_process	cerebellar Purkinje cell layer development
AN	0021766	biological_process	hippocampus development
AN	0021794	biological_process	thalamus development
AN	0021854	biological_process	hypothalamus development
AN	0021860	biological_process	pyramidal neuron development
AN	0030901	biological_process	midbrain development
AN	0045333	biological_process	cellular respiration
AN	0070469	cellular_component	respirasome
AO	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AP	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AP	0016020	cellular_component	membrane
AP	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AQ	0005515	molecular_function	protein binding
AQ	0005739	cellular_component	mitochondrion
AQ	0005743	cellular_component	mitochondrial inner membrane
AQ	0005750	cellular_component	mitochondrial respiratory chain complex III
AQ	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AQ	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AQ	0045333	biological_process	cellular respiration
AQ	0070469	cellular_component	respirasome
AQ	1902600	biological_process	proton transmembrane transport
AR	0005750	cellular_component	mitochondrial respiratory chain complex III
AR	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AS	0005515	molecular_function	protein binding
AS	0005739	cellular_component	mitochondrion
AS	0005743	cellular_component	mitochondrial inner membrane
AS	0005746	cellular_component	mitochondrial respirasome
AS	0005750	cellular_component	mitochondrial respiratory chain complex III
AS	0006119	biological_process	oxidative phosphorylation
AS	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AS	0009060	biological_process	aerobic respiration
AS	0045333	biological_process	cellular respiration
AS	0070469	cellular_component	respirasome
AT	0005739	cellular_component	mitochondrion
AT	0005743	cellular_component	mitochondrial inner membrane
AT	0005750	cellular_component	mitochondrial respiratory chain complex III
AT	0006091	biological_process	generation of precursor metabolites and energy
AT	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AT	0009055	molecular_function	electron transfer activity
AT	0045333	biological_process	cellular respiration
AT	0070469	cellular_component	respirasome
AU	0009055	molecular_function	electron transfer activity
AU	0020037	molecular_function	heme binding
AV	0001666	biological_process	response to hypoxia
AV	0005739	cellular_component	mitochondrion
AV	0005743	cellular_component	mitochondrial inner membrane
AV	0005750	cellular_component	mitochondrial respiratory chain complex III
AV	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AV	0007584	biological_process	response to nutrient
AV	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AV	0009055	molecular_function	electron transfer activity
AV	0009410	biological_process	response to xenobiotic stimulus
AV	0009636	biological_process	response to toxic substance
AV	0009725	biological_process	response to hormone
AV	0010243	biological_process	response to organonitrogen compound
AV	0014070	biological_process	response to organic cyclic compound
AV	0015990	biological_process	electron transport coupled proton transport
AV	0016020	cellular_component	membrane
AV	0016491	molecular_function	oxidoreductase activity
AV	0022904	biological_process	respiratory electron transport chain
AV	0031100	biological_process	animal organ regeneration
AV	0032991	cellular_component	protein-containing complex
AV	0033590	biological_process	response to cobalamin
AV	0033762	biological_process	response to glucagon
AV	0044877	molecular_function	protein-containing complex binding
AV	0045275	cellular_component	respiratory chain complex III
AV	0045333	biological_process	cellular respiration
AV	0045471	biological_process	response to ethanol
AV	0046686	biological_process	response to cadmium ion
AV	0046688	biological_process	response to copper ion
AV	0046689	biological_process	response to mercury ion
AV	0046872	molecular_function	metal ion binding
AV	0051592	biological_process	response to calcium ion
AV	0055093	biological_process	response to hyperoxia
AV	0070469	cellular_component	respirasome
AW	0004222	molecular_function	metalloendopeptidase activity
AW	0005515	molecular_function	protein binding
AW	0005654	cellular_component	nucleoplasm
AW	0005739	cellular_component	mitochondrion
AW	0005743	cellular_component	mitochondrial inner membrane
AW	0005750	cellular_component	mitochondrial respiratory chain complex III
AW	0006119	biological_process	oxidative phosphorylation
AW	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AW	0006508	biological_process	proteolysis
AW	0009060	biological_process	aerobic respiration
AW	0045275	cellular_component	respiratory chain complex III
AW	0045333	biological_process	cellular respiration
AW	0046872	molecular_function	metal ion binding
AW	0070469	cellular_component	respirasome
AY	0005515	molecular_function	protein binding
AY	0005739	cellular_component	mitochondrion
AY	0005743	cellular_component	mitochondrial inner membrane
AY	0005746	cellular_component	mitochondrial respirasome
AY	0005750	cellular_component	mitochondrial respiratory chain complex III
AY	0006119	biological_process	oxidative phosphorylation
AY	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AY	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AY	0009060	biological_process	aerobic respiration
AY	0014823	biological_process	response to activity
AY	0031625	molecular_function	ubiquitin protein ligase binding
AY	0043279	biological_process	response to alkaloid
AY	0044877	molecular_function	protein-containing complex binding
AY	0045333	biological_process	cellular respiration
AY	0046872	molecular_function	metal ion binding
AY	0070469	cellular_component	respirasome
AY	1902600	biological_process	proton transmembrane transport
b	0005515	molecular_function	protein binding
b	0005654	cellular_component	nucleoplasm
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
b	0009060	biological_process	aerobic respiration
b	0031966	cellular_component	mitochondrial membrane
b	0032981	biological_process	mitochondrial respiratory chain complex I assembly
b	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
b	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
b	0045271	cellular_component	respiratory chain complex I
b	0070469	cellular_component	respirasome
b	1902600	biological_process	proton transmembrane transport
B	0016020	cellular_component	membrane
B	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B0	0005751	cellular_component	mitochondrial respiratory chain complex IV
B0	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B1	0005743	cellular_component	mitochondrial inner membrane
B1	0005751	cellular_component	mitochondrial respiratory chain complex IV
B1	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B2	0005740	cellular_component	mitochondrial envelope
B2	0005751	cellular_component	mitochondrial respiratory chain complex IV
B2	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B3	0005743	cellular_component	mitochondrial inner membrane
B3	0005751	cellular_component	mitochondrial respiratory chain complex IV
B4	0005739	cellular_component	mitochondrion
B4	0045277	cellular_component	respiratory chain complex IV
B5	0005739	cellular_component	mitochondrion
B5	0005743	cellular_component	mitochondrial inner membrane
B5	0006119	biological_process	oxidative phosphorylation
B5	0045277	cellular_component	respiratory chain complex IV
B6	0005746	cellular_component	mitochondrial respirasome
B6	0005751	cellular_component	mitochondrial respiratory chain complex IV
B6	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B7	0005746	cellular_component	mitochondrial respirasome
B7	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B8	0005751	cellular_component	mitochondrial respiratory chain complex IV
B8	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B9	0005751	cellular_component	mitochondrial respiratory chain complex IV
B9	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
BA	0005515	molecular_function	protein binding
BA	0005739	cellular_component	mitochondrion
BA	0005743	cellular_component	mitochondrial inner membrane
BA	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BA	0005829	cellular_component	cytosol
BA	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BA	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BA	0009060	biological_process	aerobic respiration
BA	0010181	molecular_function	FMN binding
BA	0016491	molecular_function	oxidoreductase activity
BA	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
BA	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BA	0045271	cellular_component	respiratory chain complex I
BA	0046872	molecular_function	metal ion binding
BA	0051287	molecular_function	NAD binding
BA	0051539	molecular_function	4 iron, 4 sulfur cluster binding
BA	0070469	cellular_component	respirasome
BA	1902600	biological_process	proton transmembrane transport
Bb	0005515	molecular_function	protein binding
Bb	0005654	cellular_component	nucleoplasm
Bb	0005739	cellular_component	mitochondrion
Bb	0005743	cellular_component	mitochondrial inner membrane
Bb	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bb	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bb	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bb	0009060	biological_process	aerobic respiration
Bb	0031966	cellular_component	mitochondrial membrane
Bb	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bb	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Bb	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bb	0045271	cellular_component	respiratory chain complex I
Bb	0070469	cellular_component	respirasome
Bb	1902600	biological_process	proton transmembrane transport
BB	0016020	cellular_component	membrane
BB	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
BB	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Bc	0005739	cellular_component	mitochondrion
Bc	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bc	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BC	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BC	0048038	molecular_function	quinone binding
BC	0051536	molecular_function	iron-sulfur cluster binding
BC	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Bd	0005515	molecular_function	protein binding
Bd	0005739	cellular_component	mitochondrion
Bd	0005743	cellular_component	mitochondrial inner membrane
Bd	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bd	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bd	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bd	0009060	biological_process	aerobic respiration
Bd	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bd	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bd	0045271	cellular_component	respiratory chain complex I
Bd	0070469	cellular_component	respirasome
Bd	1902600	biological_process	proton transmembrane transport
BE	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bf	0005739	cellular_component	mitochondrion
Bf	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bg	0005515	molecular_function	protein binding
Bg	0005737	cellular_component	cytoplasm
Bg	0005739	cellular_component	mitochondrion
Bg	0005743	cellular_component	mitochondrial inner membrane
Bg	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bg	0005886	cellular_component	plasma membrane
Bg	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bg	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bg	0009060	biological_process	aerobic respiration
Bg	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bg	0035577	cellular_component	azurophil granule membrane
Bg	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bg	0045271	cellular_component	respiratory chain complex I
Bg	0070469	cellular_component	respirasome
Bg	1902600	biological_process	proton transmembrane transport
BG	0006633	biological_process	fatty acid biosynthetic process
Bh	0005515	molecular_function	protein binding
Bh	0005739	cellular_component	mitochondrion
Bh	0005743	cellular_component	mitochondrial inner membrane
Bh	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bh	0005758	cellular_component	mitochondrial intermembrane space
Bh	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bh	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bh	0009060	biological_process	aerobic respiration
Bh	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bh	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bh	0045271	cellular_component	respiratory chain complex I
Bh	0070469	cellular_component	respirasome
Bh	1902600	biological_process	proton transmembrane transport
BH	0005515	molecular_function	protein binding
BH	0005739	cellular_component	mitochondrion
BH	0005743	cellular_component	mitochondrial inner membrane
BH	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BH	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BH	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BH	0009060	biological_process	aerobic respiration
BH	0022904	biological_process	respiratory electron transport chain
BH	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BH	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BH	0045271	cellular_component	respiratory chain complex I
BH	0070469	cellular_component	respirasome
BH	1902600	biological_process	proton transmembrane transport
Bi	0001666	biological_process	response to hypoxia
Bi	0005515	molecular_function	protein binding
Bi	0005739	cellular_component	mitochondrion
Bi	0005743	cellular_component	mitochondrial inner membrane
Bi	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bi	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bi	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bi	0009060	biological_process	aerobic respiration
Bi	0019901	molecular_function	protein kinase binding
Bi	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bi	0035255	molecular_function	ionotropic glutamate receptor binding
Bi	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bi	0045271	cellular_component	respiratory chain complex I
Bi	0070469	cellular_component	respirasome
Bi	0072593	biological_process	reactive oxygen species metabolic process
Bi	1902600	biological_process	proton transmembrane transport
BI	0005515	molecular_function	protein binding
BI	0005739	cellular_component	mitochondrion
BI	0005743	cellular_component	mitochondrial inner membrane
BI	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BI	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BI	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BI	0009060	biological_process	aerobic respiration
BI	0042773	biological_process	ATP synthesis coupled electron transport
BI	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BI	0045271	cellular_component	respiratory chain complex I
BI	0070469	cellular_component	respirasome
BI	1902600	biological_process	proton transmembrane transport
Bj	0005739	cellular_component	mitochondrion
Bj	0005743	cellular_component	mitochondrial inner membrane
Bj	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bj	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bj	0016020	cellular_component	membrane
Bj	0070469	cellular_component	respirasome
Bj	1902600	biological_process	proton transmembrane transport
Bk	0005739	cellular_component	mitochondrion
Bk	0005743	cellular_component	mitochondrial inner membrane
Bk	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bk	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bk	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Bk	0042773	biological_process	ATP synthesis coupled electron transport
Bk	0070469	cellular_component	respirasome
Bk	1902600	biological_process	proton transmembrane transport
BK	0005739	cellular_component	mitochondrion
BK	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bl	0001666	biological_process	response to hypoxia
Bl	0003954	molecular_function	NADH dehydrogenase activity
Bl	0005739	cellular_component	mitochondrion
Bl	0005743	cellular_component	mitochondrial inner membrane
Bl	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bl	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bl	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bl	0009060	biological_process	aerobic respiration
Bl	0010243	biological_process	response to organonitrogen compound
Bl	0015990	biological_process	electron transport coupled proton transport
Bl	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bl	0042542	biological_process	response to hydrogen peroxide
Bl	0042773	biological_process	ATP synthesis coupled electron transport
Bl	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bl	0045271	cellular_component	respiratory chain complex I
Bl	0070469	cellular_component	respirasome
BL	0022900	biological_process	electron transport chain
Bm	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BM	0005515	molecular_function	protein binding
BM	0005739	cellular_component	mitochondrion
BM	0005743	cellular_component	mitochondrial inner membrane
BM	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BM	0005758	cellular_component	mitochondrial intermembrane space
BM	0005759	cellular_component	mitochondrial matrix
BM	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BM	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BM	0009055	molecular_function	electron transfer activity
BM	0009060	biological_process	aerobic respiration
BM	0016020	cellular_component	membrane
BM	0016491	molecular_function	oxidoreductase activity
BM	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
BM	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BM	0042773	biological_process	ATP synthesis coupled electron transport
BM	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BM	0045271	cellular_component	respiratory chain complex I
BM	0045333	biological_process	cellular respiration
BM	0046872	molecular_function	metal ion binding
BM	0051536	molecular_function	iron-sulfur cluster binding
BM	0051537	molecular_function	2 iron, 2 sulfur cluster binding
BM	0051539	molecular_function	4 iron, 4 sulfur cluster binding
BM	0070469	cellular_component	respirasome
BM	1902600	biological_process	proton transmembrane transport
Bn	0005739	cellular_component	mitochondrion
Bn	0005743	cellular_component	mitochondrial inner membrane
Bn	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bn	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bn	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bn	0009060	biological_process	aerobic respiration
Bn	0016607	cellular_component	nuclear speck
Bn	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bn	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bn	0045271	cellular_component	respiratory chain complex I
Bn	0070469	cellular_component	respirasome
Bn	1902600	biological_process	proton transmembrane transport
BN	0005515	molecular_function	protein binding
BN	0005739	cellular_component	mitochondrion
BN	0005743	cellular_component	mitochondrial inner membrane
BN	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BN	0005829	cellular_component	cytosol
BN	0006979	biological_process	response to oxidative stress
BN	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BN	0009060	biological_process	aerobic respiration
BN	0016020	cellular_component	membrane
BN	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BN	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
BN	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BN	0045271	cellular_component	respiratory chain complex I
BN	0070469	cellular_component	respirasome
BN	1902600	biological_process	proton transmembrane transport
Bo	0005654	cellular_component	nucleoplasm
Bo	0005739	cellular_component	mitochondrion
Bo	0005743	cellular_component	mitochondrial inner membrane
Bo	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bo	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bo	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bo	0009060	biological_process	aerobic respiration
Bo	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bo	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bo	0045271	cellular_component	respiratory chain complex I
Bo	0070469	cellular_component	respirasome
Bo	1902600	biological_process	proton transmembrane transport
BO	0016491	molecular_function	oxidoreductase activity
Bp	0005515	molecular_function	protein binding
Bp	0005739	cellular_component	mitochondrion
Bp	0005743	cellular_component	mitochondrial inner membrane
Bp	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bp	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bp	0007605	biological_process	sensory perception of sound
Bp	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bp	0009060	biological_process	aerobic respiration
Bp	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bp	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bp	0045271	cellular_component	respiratory chain complex I
Bp	0070469	cellular_component	respirasome
Bp	1902600	biological_process	proton transmembrane transport
BP	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BP	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
BQ	0003954	molecular_function	NADH dehydrogenase activity
BQ	0005515	molecular_function	protein binding
BQ	0005654	cellular_component	nucleoplasm
BQ	0005739	cellular_component	mitochondrion
BQ	0005743	cellular_component	mitochondrial inner membrane
BQ	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BQ	0005759	cellular_component	mitochondrial matrix
BQ	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BQ	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BQ	0009055	molecular_function	electron transfer activity
BQ	0009060	biological_process	aerobic respiration
BQ	0016491	molecular_function	oxidoreductase activity
BQ	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
BQ	0019826	molecular_function	oxygen sensor activity
BQ	0022008	biological_process	neurogenesis
BQ	0031625	molecular_function	ubiquitin protein ligase binding
BQ	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BQ	0042063	biological_process	gliogenesis
BQ	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
BQ	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BQ	0045271	cellular_component	respiratory chain complex I
BQ	0046872	molecular_function	metal ion binding
BQ	0048038	molecular_function	quinone binding
BQ	0051287	molecular_function	NAD binding
BQ	0051539	molecular_function	4 iron, 4 sulfur cluster binding
BQ	0061351	biological_process	neural precursor cell proliferation
BQ	0070469	cellular_component	respirasome
BQ	0071453	biological_process	cellular response to oxygen levels
BQ	1902600	biological_process	proton transmembrane transport
Br	0001666	biological_process	response to hypoxia
Br	0001701	biological_process	in utero embryonic development
Br	0003954	molecular_function	NADH dehydrogenase activity
Br	0005739	cellular_component	mitochondrion
Br	0005743	cellular_component	mitochondrial inner membrane
Br	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Br	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Br	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Br	0009060	biological_process	aerobic respiration
Br	0015990	biological_process	electron transport coupled proton transport
Br	0021549	biological_process	cerebellum development
Br	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Br	0035094	biological_process	response to nicotine
Br	0042773	biological_process	ATP synthesis coupled electron transport
Br	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Br	0045271	cellular_component	respiratory chain complex I
Br	0045471	biological_process	response to ethanol
Br	0048039	molecular_function	ubiquinone binding
Br	0070469	cellular_component	respirasome
Bs	0005739	cellular_component	mitochondrion
Bs	0005743	cellular_component	mitochondrial inner membrane
Bs	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bs	0016020	cellular_component	membrane
Bs	0070469	cellular_component	respirasome
Bs	1902600	biological_process	proton transmembrane transport
BS	0005739	cellular_component	mitochondrion
BS	0005743	cellular_component	mitochondrial inner membrane
BS	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BS	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BS	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BS	0009060	biological_process	aerobic respiration
BS	0031966	cellular_component	mitochondrial membrane
BS	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BS	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BS	0045271	cellular_component	respiratory chain complex I
BS	0070469	cellular_component	respirasome
BS	1902600	biological_process	proton transmembrane transport
BT	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BT	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bu	0005515	molecular_function	protein binding
Bu	0005739	cellular_component	mitochondrion
Bu	0005743	cellular_component	mitochondrial inner membrane
Bu	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bu	0005758	cellular_component	mitochondrial intermembrane space
Bu	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bu	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bu	0009060	biological_process	aerobic respiration
Bu	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bu	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bu	0044877	molecular_function	protein-containing complex binding
Bu	0045271	cellular_component	respiratory chain complex I
Bu	0070469	cellular_component	respirasome
Bu	1902600	biological_process	proton transmembrane transport
BU	0005515	molecular_function	protein binding
BU	0005739	cellular_component	mitochondrion
BU	0005743	cellular_component	mitochondrial inner membrane
BU	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BU	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BU	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
BU	0009060	biological_process	aerobic respiration
BU	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BU	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BU	0045271	cellular_component	respiratory chain complex I
BU	0070469	cellular_component	respirasome
BU	1902600	biological_process	proton transmembrane transport
Bv	0005739	cellular_component	mitochondrion
BV	0005515	molecular_function	protein binding
BV	0005739	cellular_component	mitochondrion
BV	0005743	cellular_component	mitochondrial inner membrane
BV	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BV	0009060	biological_process	aerobic respiration
BV	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BV	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BV	0045271	cellular_component	respiratory chain complex I
BV	0070469	cellular_component	respirasome
Bw	0005737	cellular_component	cytoplasm
Bw	0005739	cellular_component	mitochondrion
Bw	0005743	cellular_component	mitochondrial inner membrane
Bw	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bw	0005759	cellular_component	mitochondrial matrix
Bw	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Bw	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Bw	0009060	biological_process	aerobic respiration
Bw	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Bw	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Bw	0045271	cellular_component	respiratory chain complex I
Bw	0070469	cellular_component	respirasome
Bw	1902600	biological_process	proton transmembrane transport
BW	0005515	molecular_function	protein binding
BW	0005524	molecular_function	ATP binding
BW	0005634	cellular_component	nucleus
BW	0005654	cellular_component	nucleoplasm
BW	0005737	cellular_component	cytoplasm
BW	0005739	cellular_component	mitochondrion
BW	0005743	cellular_component	mitochondrial inner membrane
BW	0005746	cellular_component	mitochondrial respirasome
BW	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
BW	0006915	biological_process	apoptotic process
BW	0009060	biological_process	aerobic respiration
BW	0031966	cellular_component	mitochondrial membrane
BW	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BW	0035458	biological_process	cellular response to interferon-beta
BW	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
BW	0045039	biological_process	protein insertion into mitochondrial inner membrane
BW	0045271	cellular_component	respiratory chain complex I
BW	0045732	biological_process	positive regulation of protein catabolic process
BW	0045892	biological_process	negative regulation of DNA-templated transcription
BW	0061133	molecular_function	endopeptidase activator activity
BW	0070469	cellular_component	respirasome
BW	0071300	biological_process	cellular response to retinoic acid
BW	0097191	biological_process	extrinsic apoptotic signaling pathway
BW	1900119	biological_process	positive regulation of execution phase of apoptosis
Bx	0004129	molecular_function	cytochrome-c oxidase activity
Bx	0005739	cellular_component	mitochondrion
Bx	0005743	cellular_component	mitochondrial inner membrane
Bx	0005751	cellular_component	mitochondrial respiratory chain complex IV
Bx	0006119	biological_process	oxidative phosphorylation
Bx	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Bx	0009060	biological_process	aerobic respiration
Bx	0015990	biological_process	electron transport coupled proton transport
Bx	0016020	cellular_component	membrane
Bx	0020037	molecular_function	heme binding
Bx	0045277	cellular_component	respiratory chain complex IV
Bx	0046872	molecular_function	metal ion binding
Bx	0070469	cellular_component	respirasome
BX	0006633	biological_process	fatty acid biosynthetic process
By	0004129	molecular_function	cytochrome-c oxidase activity
By	0005507	molecular_function	copper ion binding
By	0005739	cellular_component	mitochondrion
By	0005743	cellular_component	mitochondrial inner membrane
By	0016020	cellular_component	membrane
By	0016491	molecular_function	oxidoreductase activity
By	0022900	biological_process	electron transport chain
By	0042773	biological_process	ATP synthesis coupled electron transport
By	0045277	cellular_component	respiratory chain complex IV
By	0046872	molecular_function	metal ion binding
By	0070469	cellular_component	respirasome
By	1902600	biological_process	proton transmembrane transport
BY	0005743	cellular_component	mitochondrial inner membrane
BY	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Bz	0004129	molecular_function	cytochrome-c oxidase activity
Bz	0005739	cellular_component	mitochondrion
Bz	0005743	cellular_component	mitochondrial inner membrane
Bz	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Bz	0008535	biological_process	respiratory chain complex IV assembly
Bz	0009055	molecular_function	electron transfer activity
Bz	0016020	cellular_component	membrane
Bz	0019646	biological_process	aerobic electron transport chain
Bz	0022904	biological_process	respiratory electron transport chain
Bz	0045277	cellular_component	respiratory chain complex IV
Bz	1902600	biological_process	proton transmembrane transport
BZ	0005739	cellular_component	mitochondrion
BZ	0022900	biological_process	electron transport chain
c	0005739	cellular_component	mitochondrion
c	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0048038	molecular_function	quinone binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
d	0005515	molecular_function	protein binding
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
d	0009060	biological_process	aerobic respiration
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	0070469	cellular_component	respirasome
d	1902600	biological_process	proton transmembrane transport
E	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
f	0005739	cellular_component	mitochondrion
f	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
g	0005886	cellular_component	plasma membrane
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
g	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
g	0009060	biological_process	aerobic respiration
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0035577	cellular_component	azurophil granule membrane
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
g	0070469	cellular_component	respirasome
g	1902600	biological_process	proton transmembrane transport
G	0006633	biological_process	fatty acid biosynthetic process
h	0005515	molecular_function	protein binding
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
h	0005758	cellular_component	mitochondrial intermembrane space
h	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
h	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
h	0009060	biological_process	aerobic respiration
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
h	0070469	cellular_component	respirasome
h	1902600	biological_process	proton transmembrane transport
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0022904	biological_process	respiratory electron transport chain
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
H	0045271	cellular_component	respiratory chain complex I
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
i	0001666	biological_process	response to hypoxia
i	0005515	molecular_function	protein binding
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0009060	biological_process	aerobic respiration
i	0019901	molecular_function	protein kinase binding
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0035255	molecular_function	ionotropic glutamate receptor binding
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
i	0070469	cellular_component	respirasome
i	0072593	biological_process	reactive oxygen species metabolic process
i	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0009060	biological_process	aerobic respiration
I	0042773	biological_process	ATP synthesis coupled electron transport
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045271	cellular_component	respiratory chain complex I
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0016020	cellular_component	membrane
j	0070469	cellular_component	respirasome
j	1902600	biological_process	proton transmembrane transport
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
k	0042773	biological_process	ATP synthesis coupled electron transport
k	0070469	cellular_component	respirasome
k	1902600	biological_process	proton transmembrane transport
K	0005739	cellular_component	mitochondrion
K	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
l	0001666	biological_process	response to hypoxia
l	0003954	molecular_function	NADH dehydrogenase activity
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0009060	biological_process	aerobic respiration
l	0010243	biological_process	response to organonitrogen compound
l	0015990	biological_process	electron transport coupled proton transport
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042542	biological_process	response to hydrogen peroxide
l	0042773	biological_process	ATP synthesis coupled electron transport
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
l	0070469	cellular_component	respirasome
L	0022900	biological_process	electron transport chain
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009055	molecular_function	electron transfer activity
M	0009060	biological_process	aerobic respiration
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
M	0070469	cellular_component	respirasome
M	1902600	biological_process	proton transmembrane transport
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
n	0009060	biological_process	aerobic respiration
n	0016607	cellular_component	nuclear speck
n	0032981	biological_process	mitochondrial respiratory chain complex I assembly
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
n	0070469	cellular_component	respirasome
n	1902600	biological_process	proton transmembrane transport
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
N	0005829	cellular_component	cytosol
N	0006979	biological_process	response to oxidative stress
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	0070469	cellular_component	respirasome
N	1902600	biological_process	proton transmembrane transport
o	0005654	cellular_component	nucleoplasm
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	0070469	cellular_component	respirasome
o	1902600	biological_process	proton transmembrane transport
O	0016491	molecular_function	oxidoreductase activity
p	0005515	molecular_function	protein binding
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0007605	biological_process	sensory perception of sound
p	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
p	0009060	biological_process	aerobic respiration
p	0032981	biological_process	mitochondrial respiratory chain complex I assembly
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I
p	0070469	cellular_component	respirasome
p	1902600	biological_process	proton transmembrane transport
P	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
P	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0003954	molecular_function	NADH dehydrogenase activity
Q	0005515	molecular_function	protein binding
Q	0005654	cellular_component	nucleoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Q	0005759	cellular_component	mitochondrial matrix
Q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009055	molecular_function	electron transfer activity
Q	0009060	biological_process	aerobic respiration
Q	0016491	molecular_function	oxidoreductase activity
Q	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0019826	molecular_function	oxygen sensor activity
Q	0022008	biological_process	neurogenesis
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0042063	biological_process	gliogenesis
Q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Q	0045271	cellular_component	respiratory chain complex I
Q	0046872	molecular_function	metal ion binding
Q	0048038	molecular_function	quinone binding
Q	0051287	molecular_function	NAD binding
Q	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Q	0061351	biological_process	neural precursor cell proliferation
Q	0070469	cellular_component	respirasome
Q	0071453	biological_process	cellular response to oxygen levels
Q	1902600	biological_process	proton transmembrane transport
r	0001666	biological_process	response to hypoxia
r	0001701	biological_process	in utero embryonic development
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0015990	biological_process	electron transport coupled proton transport
r	0021549	biological_process	cerebellum development
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0035094	biological_process	response to nicotine
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
r	0045271	cellular_component	respiratory chain complex I
r	0045471	biological_process	response to ethanol
r	0048039	molecular_function	ubiquinone binding
r	0070469	cellular_component	respirasome
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0016020	cellular_component	membrane
s	0070469	cellular_component	respirasome
s	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
S	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0031966	cellular_component	mitochondrial membrane
S	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045271	cellular_component	respiratory chain complex I
S	0070469	cellular_component	respirasome
S	1902600	biological_process	proton transmembrane transport
T	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
T	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0005515	molecular_function	protein binding
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
u	0005758	cellular_component	mitochondrial intermembrane space
u	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
u	0009060	biological_process	aerobic respiration
u	0032981	biological_process	mitochondrial respiratory chain complex I assembly
u	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
u	0044877	molecular_function	protein-containing complex binding
u	0045271	cellular_component	respiratory chain complex I
u	0070469	cellular_component	respirasome
u	1902600	biological_process	proton transmembrane transport
U	0005515	molecular_function	protein binding
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0009060	biological_process	aerobic respiration
U	0032981	biological_process	mitochondrial respiratory chain complex I assembly
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0045271	cellular_component	respiratory chain complex I
U	0070469	cellular_component	respirasome
U	1902600	biological_process	proton transmembrane transport
v	0005739	cellular_component	mitochondrion
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
V	0009060	biological_process	aerobic respiration
V	0032981	biological_process	mitochondrial respiratory chain complex I assembly
V	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
V	0045271	cellular_component	respiratory chain complex I
V	0070469	cellular_component	respirasome
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
w	0005759	cellular_component	mitochondrial matrix
w	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
w	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
w	0009060	biological_process	aerobic respiration
w	0032981	biological_process	mitochondrial respiratory chain complex I assembly
w	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
w	0045271	cellular_component	respiratory chain complex I
w	0070469	cellular_component	respirasome
w	1902600	biological_process	proton transmembrane transport
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005746	cellular_component	mitochondrial respirasome
W	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
W	0006915	biological_process	apoptotic process
W	0009060	biological_process	aerobic respiration
W	0031966	cellular_component	mitochondrial membrane
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0035458	biological_process	cellular response to interferon-beta
W	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
W	0045039	biological_process	protein insertion into mitochondrial inner membrane
W	0045271	cellular_component	respiratory chain complex I
W	0045732	biological_process	positive regulation of protein catabolic process
W	0045892	biological_process	negative regulation of DNA-templated transcription
W	0061133	molecular_function	endopeptidase activator activity
W	0070469	cellular_component	respirasome
W	0071300	biological_process	cellular response to retinoic acid
W	0097191	biological_process	extrinsic apoptotic signaling pathway
W	1900119	biological_process	positive regulation of execution phase of apoptosis
x	0004129	molecular_function	cytochrome-c oxidase activity
x	0005739	cellular_component	mitochondrion
x	0005743	cellular_component	mitochondrial inner membrane
x	0005751	cellular_component	mitochondrial respiratory chain complex IV
x	0006119	biological_process	oxidative phosphorylation
x	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
x	0009060	biological_process	aerobic respiration
x	0015990	biological_process	electron transport coupled proton transport
x	0016020	cellular_component	membrane
x	0020037	molecular_function	heme binding
x	0045277	cellular_component	respiratory chain complex IV
x	0046872	molecular_function	metal ion binding
x	0070469	cellular_component	respirasome
X	0006633	biological_process	fatty acid biosynthetic process
y	0004129	molecular_function	cytochrome-c oxidase activity
y	0005507	molecular_function	copper ion binding
y	0005739	cellular_component	mitochondrion
y	0005743	cellular_component	mitochondrial inner membrane
y	0016020	cellular_component	membrane
y	0016491	molecular_function	oxidoreductase activity
y	0022900	biological_process	electron transport chain
y	0042773	biological_process	ATP synthesis coupled electron transport
y	0045277	cellular_component	respiratory chain complex IV
y	0046872	molecular_function	metal ion binding
y	0070469	cellular_component	respirasome
y	1902600	biological_process	proton transmembrane transport
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
z	0004129	molecular_function	cytochrome-c oxidase activity
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
z	0008535	biological_process	respiratory chain complex IV assembly
z	0009055	molecular_function	electron transfer activity
z	0016020	cellular_component	membrane
z	0019646	biological_process	aerobic electron transport chain
z	0022904	biological_process	respiratory electron transport chain
z	0045277	cellular_component	respiratory chain complex IV
z	1902600	biological_process	proton transmembrane transport
Z	0005739	cellular_component	mitochondrion
Z	0022900	biological_process	electron transport chain

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SF4 A 501

Chain	Residue
A	ILE205
A	CYS425
A	PRO223
A	SER378
A	CYS379
A	GLN381
A	CYS382
A	CYS385
A	THR423
A	ILE424

site_id	AC2
Number of Residues	11
Details	binding site for residue FMN A 502

Chain	Residue
A	GLY87
A	ARG88
A	GLY89
A	ASN116
A	GLU119
A	GLY207
A	GLU208
A	GLU209
A	ALA243
A	ASN244
A	ALA426

site_id	AC3
Number of Residues	8
Details	binding site for residue SF4 B 301

Chain	Residue
B	CYS111
B	ALA113
B	CYS114
B	LYS115
B	CYS117
B	CYS160
B	ALA164
B	ILE165

site_id	AC4
Number of Residues	11
Details	binding site for residue SF4 B 302

Chain	Residue
B	HIS99
B	CYS121
B	PRO122
B	CYS150
B	ILE151
B	TYR152
B	CYS153
B	GLY154
B	PHE155
B	CYS156
B	GLU167

site_id	AC5
Number of Residues	11
Details	binding site for residue PLX B 303

Chain	Residue
B	THR58
B	TRP61
Q	ARG266
Q	ASN270
s	MET183
s	MET184
s	ILE273
s	TYR277
s	PHE280
s	LEU288
s	ASN292

site_id	AC6
Number of Residues	9
Details	binding site for residue SF4 C 301

Chain	Residue
C	ALA87
C	CYS88
C	CYS89
C	GLY151
C	SER152
C	CYS153
C	CYS183
C	PRO184
Q	HIS223

site_id	AC7
Number of Residues	9
Details	binding site for residue 8Q1 E 201

Chain	Residue
E	MET25
E	TRP39
E	MET66
E	PHE67
E	ASN70
E	VAL79
E	LEU82
E	VAL83
G	SER112

site_id	AC8
Number of Residues	18
Details	binding site for residue NDP J 401

Chain	Residue
J	GLY60
J	THR62
J	GLY63
J	PHE64
J	LEU65
J	ALA110
J	LEU129
J	ILE130
J	GLY131
J	ARG132
J	PHE145
J	SER168
J	HIS169
J	TYR180
J	LYS184
J	PRO203
J	ILE206
J	ARG212

site_id	AC9
Number of Residues	9
Details	binding site for residue SF4 M 801

Chain	Residue
M	HIS124
M	ASP127
M	CYS128
M	CYS131
M	GLY134
M	CYS137
M	GLN140
M	VAL228
M	GLY229

site_id	AD1
Number of Residues	9
Details	binding site for residue SF4 M 802

Chain	Residue
M	CYS182
M	CYS226
M	PRO227
M	VAL228
M	ALA230
M	LEU231
M	CYS176
M	ILE177
M	CYS179

site_id	AD2
Number of Residues	9
Details	binding site for residue FES M 803

Chain	Residue
M	ARG62
M	CYS64
M	TYR65
M	ALA72
M	ASN74
M	CYS75
M	MET77
M	CYS78
M	CYS92

site_id	AD3
Number of Residues	9
Details	binding site for residue FES O 301

Chain	Residue
O	CYS135
O	THR137
O	PRO139
O	CYS140
O	CYS176
O	LEU177
O	GLY178
O	ALA179
O	CYS180

site_id	AD4
Number of Residues	8
Details	binding site for residue PLX U 101

Chain	Residue
U	ALA12
U	GLU16
U	PHE23
U	GLY26
j	TRP106
j	LEU107
j	ASP112
s	PRO295

site_id	AD5
Number of Residues	11
Details	binding site for residue CDL V 201

Chain	Residue
V	THR35
V	TYR39
V	ARG40
V	ASN44
V	TYR59
V	THR62
i	PRO110
i	HIS112
i	LEU160
l	ILE576
l	THR577

site_id	AD6
Number of Residues	5
Details	binding site for residue PEE V 202

Chain	Residue
V	TRP133
i	LEU276
i	ILE277
i	THR284
l	PEE701

site_id	AD7
Number of Residues	12
Details	binding site for residue PEE W 201

Chain	Residue
S	HIS40
W	PHE140
W	MET141
W	TYR143
W	THR144
j	LEU7
m	VAL37
m	LEU44
m	PHE56
s	LEU77
s	LEU98
s	PHE104

site_id	AD8
Number of Residues	9
Details	binding site for residue PLX b 201

Chain	Residue
a	THR87
a	ASN90
a	GLN95
b	TYR84
b	TYR88
b	GLU92
d	ARG43
e	TYR108
r	PLX502

site_id	AD9
Number of Residues	10
Details	binding site for residue PLX g 201

Chain	Residue
g	PRO9
g	LEU10
g	PHE12
g	ARG77
h	PRO2
h	PHE3
i	THR132
i	TRP133
i	TYR143
i	ILE346

site_id	AE1
Number of Residues	4
Details	binding site for residue PLX g 202

Chain	Residue
f	HIS62
g	LEU25
g	PHE35
g	PHE68

site_id	AE2
Number of Residues	10
Details	binding site for residue PLX g 203

Chain	Residue
f	LYS43
f	THR47
g	ARG48
g	ARG50
g	ARG59
g	LEU62
g	TYR63
g	PHE67
i	PRO324
i	PHE325

site_id	AE3
Number of Residues	9
Details	binding site for residue CDL i 401

Chain	Residue
g	LEU46
i	THR238
i	TRP239
i	THR241
i	PRO242
i	LEU243
r	TRP16
r	SER90
r	LYS93

site_id	AE4
Number of Residues	11
Details	binding site for residue PEE l 701

Chain	Residue
Q	GLN46
Q	TYR53
V	PEE202
i	ILE285
i	LEU288
i	TYR291
i	ARG295
l	SER567
l	GLN570
l	ILE571
r	VAL155

site_id	AE5
Number of Residues	11
Details	binding site for residue PEE l 702

Chain	Residue
c	ARG116
l	THR166
l	GLN170
l	LEU173
l	TYR174
l	MET533
l	HIS534
l	ILE537
l	PRO538
l	GLY541
l	THR544

site_id	AE6
Number of Residues	13
Details	binding site for residue CDL l 703

Chain	Residue
a	LEU68
a	LEU71
a	ARG72
l	THR22
l	LEU23
l	PRO26
l	LYS28
l	GLN116
l	LYS119
l	TYR120
r	LEU354
r	PHE357
r	LEU360

site_id	AE7
Number of Residues	6
Details	binding site for residue CDL l 704

Chain	Residue
c	ASP148
l	SER209
l	THR211
l	LEU214
l	LEU272
r	ASN390

site_id	AE8
Number of Residues	11
Details	binding site for residue CDL n 101

Chain	Residue
g	THR26
g	LEU31
g	TYR32
i	PRO338
n	TYR26
n	LYS30
n	ARG34
r	THR55
r	PHE121
u	PHE169
u	TRP170

site_id	AE9
Number of Residues	15
Details	binding site for residue 8Q1 p 201

Chain	Residue
X	ASP111
X	SER112
X	LEU113
p	GLN13
p	ALA23
p	HIS26
p	LEU27
p	MET44
p	ARG47
p	PHE48
p	HIS51
p	LYS52
p	GLU54
p	ALA60
p	ARG74

site_id	AF1
Number of Residues	7
Details	binding site for residue PLX r 501

Chain	Residue
o	TYR102
r	ASN188
r	TRP190
r	ASN193
r	HIS256
r	MET257
r	PRO260

site_id	AF2
Number of Residues	8
Details	binding site for residue PLX r 502

Chain	Residue
b	PLX201
e	ALA107
e	TYR108
l	ILE16
r	LEU68
r	TRP71
r	LEU447
r	ASN450

site_id	AF3
Number of Residues	3
Details	binding site for residue CU x 601

Chain	Residue
x	HIS240
x	HIS290
x	HIS291

site_id	AF4
Number of Residues	3
Details	binding site for residue MG x 602

Chain	Residue
x	HIS368
x	ASP369
y	GLU198

site_id	AF5
Number of Residues	23
Details	binding site for residue HEA x 603

Chain	Residue
x	GLY27
x	MET28
x	SER34
x	ILE37
x	ARG38
x	TYR54
x	VAL58
x	HIS61
x	ALA62
x	MET65
x	ILE66
x	VAL70
x	GLY125
x	TRP126
x	TYR371
x	PHE377
x	HIS378
x	SER382
x	PHE425
x	GLN428
x	ARG438
x	ARG439
x	MET468

site_id	AF6
Number of Residues	22
Details	binding site for residue HEA x 604

Chain	Residue
x	TRP126
x	TRP236
x	VAL243
x	TYR244
x	HIS290
x	HIS291
x	THR309
x	ALA313
x	THR316
x	GLY317
x	GLY352
x	LEU353
x	GLY355
x	ILE356
x	LEU358
x	ALA359
x	ASP364
x	HIS368
x	HIS376
x	PHE377
x	VAL380
x	ARG438

site_id	AF7
Number of Residues	5
Details	binding site for residue CU y 301

Chain	Residue
y	HIS161
y	CYS196
y	CYS200
y	MET207
y	CU302

site_id	AF8
Number of Residues	5
Details	binding site for residue CU y 302

Chain	Residue
y	CYS196
y	GLU198
y	CYS200
y	HIS204
y	CU301

site_id	AF9
Number of Residues	4
Details	binding site for residue ZN 2 101

Chain	Residue
2	CYS60
2	CYS62
2	CYS82
2	CYS85

site_id	AG1
Number of Residues	8
Details	binding site for residue CDL AA 101

Chain	Residue
AA	ARG41
AA	ILE42
AA	SER45
AF	HIS73
AH	CDL403
AJ	ALA29
AJ	PHE33
AJ	PEE403

site_id	AG2
Number of Residues	6
Details	binding site for residue FES AC 301

Chain	Residue
AC	CYS217
AC	HIS219
AC	LEU220
AC	CYS236
AC	HIS239
AC	SER241

site_id	AG3
Number of Residues	8
Details	binding site for residue CDL AG 101

Chain	Residue
AC	VAL137
AC	SER141
AG	ASP37
AG	TRP38
AG	ARG39
AV	TYR155
AV	ILE156
AV	TRP163

site_id	AG4
Number of Residues	10
Details	binding site for residue PEE AH 401

Chain	Residue
AC	ASN131
AC	ALA132
AC	PHE136
AD	ASP37
AH	HIS284
AH	MET288
AH	LYS291
AJ	LEU236
AJ	MET240
AL	PLX501

site_id	AG5
Number of Residues	17
Details	binding site for residue HEC AH 402

Chain	Residue
AH	VAL120
AH	CYS121
AH	CYS124
AH	HIS125
AH	ASN189
AH	LEU197
AH	ILE200
AH	ARG204
AH	TYR210
AH	LEU214
AH	PHE237
AH	ILE242
AH	ALA243
AH	MET244
AH	PRO247
AH	VAL270
AP	HIS239

site_id	AG6
Number of Residues	14
Details	binding site for residue CDL AH 403

Chain	Residue
AA	ASN37
AA	ARG41
AA	CDL101
AF	LYS72
AF	HIS73
AH	TYR304
AH	LYS307
AH	ARG308
AH	LYS315
AJ	ASN32
AJ	LYS227
AJ	LEU230
AJ	LEU234
AJ	SER238

site_id	AG7
Number of Residues	15
Details	binding site for residue HEM AJ 401

Chain	Residue
AJ	LEU41
AJ	GLN44
AJ	ILE45
AJ	GLY48
AJ	LEU51
AJ	ALA52
AJ	ARG80
AJ	HIS83
AJ	GLY130
AJ	LEU133
AJ	PRO134
AJ	HIS182
AJ	PHE183
AJ	PRO186
AJ	TYR273

site_id	AG8
Number of Residues	16
Details	binding site for residue HEM AJ 402

Chain	Residue
AJ	TRP31
AJ	GLY34
AJ	SER35
AJ	LEU37
AJ	HIS97
AJ	ILE98
AJ	ARG100
AJ	SER106
AJ	TYR109
AJ	TRP113
AJ	GLY116
AJ	LEU119
AJ	HIS196
AJ	LEU200
AJ	SER205
AJ	ASN206

site_id	AG9
Number of Residues	15
Details	binding site for residue PEE AJ 403

Chain	Residue
AA	GLU44
AA	VAL49
AA	CDL101
AJ	TRP30
AJ	ILE92
AJ	PHE95
AJ	LEU96
AJ	GLY99
AJ	ARG100
AJ	TYR103
AJ	TYR104
AJ	MET316
AJ	TYR325
AJ	TRP326
AJ	LEU332

site_id	AH1
Number of Residues	10
Details	binding site for residue CDL AJ 404

Chain	Residue
AJ	THR194
AJ	LEU195
AJ	LEU197
AJ	LEU198
AJ	HIS201
AV	LEU13
AV	SER17
AV	THR194
AV	LEU198
AV	HIS201

site_id	AH2
Number of Residues	8
Details	binding site for residue CDL AJ 405

Chain	Residue
AJ	ASP159
AJ	LEU160
AJ	TRP163
AP	THR134
AP	VAL137
AP	SER138
AT	THR36
AY	PEE502

site_id	AH3
Number of Residues	10
Details	binding site for residue PLX AL 501

Chain	Residue
AC	TYR115
AC	THR118
AD	PHE15
AD	THR18
AD	PHE21
AD	ALA22
AH	PEE401
AJ	ALA229
AL	PHE476
AL	PEE503

site_id	AH4
Number of Residues	10
Details	binding site for residue CDL AL 502

Chain	Residue
AJ	ARG5
AJ	PHE18
AJ	ILE19
AJ	HIS221
AL	PHE370
AL	ARG470
AL	TRP477
AL	LEU478
AL	ARG479
AL	PEE503

site_id	AH5
Number of Residues	5
Details	binding site for residue PEE AL 503

Chain	Residue
AJ	HIS221
AL	SER473
AL	PHE476
AL	PLX501
AL	CDL502

site_id	AH6
Number of Residues	8
Details	binding site for residue PLX AN 101

Chain	Residue
AN	ARG43
V	TYR108
V	GLY109
V	ALA112
l	LEU553
o	PRO82
o	ALA91
o	PHE95

site_id	AH7
Number of Residues	7
Details	binding site for residue CDL AN 102

Chain	Residue
AN	ARG41
AN	SER45
AS	HIS73
AU	CDL403
AV	ALA29
AV	PHE33
AV	PEE403

site_id	AH8
Number of Residues	8
Details	binding site for residue FES AP 301

Chain	Residue
AP	CYS217
AP	HIS219
AP	LEU220
AP	CYS222
AP	CYS236
AP	CYS238
AP	HIS239
AP	SER241

site_id	AH9
Number of Residues	12
Details	binding site for residue PLX AQ 101

Chain	Residue
AP	TYR115
AP	THR118
AP	THR122
AP	VAL125
AQ	PHE15
AQ	ARG16
AQ	THR18
AQ	PHE21
AQ	ALA22
AY	PHE476
AY	CDL501
AY	PEE502

site_id	AI1
Number of Residues	3
Details	binding site for residue PLX AT 101

Chain	Residue
AT	ARG9
AT	LEU13
AY	TRP477

site_id	AI2
Number of Residues	9
Details	binding site for residue PEE AU 401

Chain	Residue
AP	TYR127
AP	ALA128
AP	ASN131
AU	MET288
AU	LYS291
AU	MET295
AU	MET296
AV	LEU236
AV	MET240

site_id	AI3
Number of Residues	15
Details	binding site for residue HEC AU 402

Chain	Residue
AC	HIS239
AU	VAL120
AU	CYS121
AU	CYS124
AU	HIS125
AU	ILE200
AU	ARG204
AU	TYR210
AU	LEU214
AU	LEU215
AU	PHE237
AU	ILE242
AU	MET244
AU	PRO247
AU	VAL270

site_id	AI4
Number of Residues	11
Details	binding site for residue CDL AU 403

Chain	Residue
AN	VAL30
AN	CDL102
AU	PRO301
AU	TYR304
AU	LYS307
AU	ARG308
AU	LYS315
AV	LEU36
AV	LYS227
AV	LEU230
AV	LEU234

site_id	AI5
Number of Residues	14
Details	binding site for residue HEM AV 401

Chain	Residue
AV	LEU41
AV	GLN44
AV	ILE45
AV	GLY48
AV	LEU49
AV	ARG80
AV	HIS83
AV	ALA87
AV	PHE90
AV	GLY130
AV	HIS182
AV	PHE183
AV	PRO186
AV	TYR273

site_id	AI6
Number of Residues	17
Details	binding site for residue HEM AV 402

Chain	Residue
AV	TRP31
AV	GLY34
AV	SER35
AV	LEU37
AV	GLY38
AV	LEU94
AV	HIS97
AV	ILE98
AV	SER106
AV	TYR109
AV	GLY116
AV	LEU119
AV	HIS196
AV	LEU197
AV	LEU200
AV	SER205
AV	ASN206

site_id	AI7
Number of Residues	13
Details	binding site for residue PEE AV 403

Chain	Residue
AN	VAL49
AN	PHE53
AN	CDL102
AV	TRP30
AV	PHE95
AV	LEU96
AV	TYR103
AV	TYR104
AV	MET316
AV	TYR325
AV	TRP326
AV	LEU332
AV	LEU333

site_id	AI8
Number of Residues	9
Details	binding site for residue CDL AY 501

Chain	Residue
AQ	PLX101
AT	TRP24
AV	ARG5
AV	HIS221
AY	PHE370
AY	TRP477
AY	LEU478
AY	ARG479
AY	PEE502

site_id	AI9
Number of Residues	10
Details	binding site for residue PEE AY 502

Chain	Residue
AJ	CDL405
AP	ALA126
AQ	PLX101
AT	ALA35
AV	LEU10
AV	ILE14
AV	HIS221
AY	SER473
AY	PHE476
AY	CDL501

site_id	AJ1
Number of Residues	10
Details	binding site for residue SF4 BA 501

Chain	Residue
BA	ILE205
BA	PRO223
BA	SER378
BA	CYS379
BA	GLN381
BA	CYS382
BA	CYS385
BA	THR423
BA	ILE424
BA	CYS425

site_id	AJ2
Number of Residues	11
Details	binding site for residue FMN BA 502

Chain	Residue
BA	GLY87
BA	ARG88
BA	GLY89
BA	ASN116
BA	GLU119
BA	GLY207
BA	GLU208
BA	GLU209
BA	ALA243
BA	ASN244
BA	ALA426

site_id	AJ3
Number of Residues	8
Details	binding site for residue SF4 BB 301

Chain	Residue
BB	CYS111
BB	ALA113
BB	CYS114
BB	LYS115
BB	CYS117
BB	CYS160
BB	ALA164
BB	ILE165

site_id	AJ4
Number of Residues	11
Details	binding site for residue SF4 BB 302

Chain	Residue
BB	HIS99
BB	CYS121
BB	PRO122
BB	CYS150
BB	ILE151
BB	TYR152
BB	CYS153
BB	GLY154
BB	PHE155
BB	CYS156
BB	GLU167

site_id	AJ5
Number of Residues	11
Details	binding site for residue PLX BB 303

Chain	Residue
BB	THR58
BB	TRP61
BQ	ARG266
BQ	ASN270
Bs	MET183
Bs	MET184
Bs	ILE273
Bs	TYR277
Bs	PHE280
Bs	LEU288
Bs	ASN292

site_id	AJ6
Number of Residues	9
Details	binding site for residue SF4 BC 301

Chain	Residue
BC	ALA87
BC	CYS88
BC	CYS89
BC	GLY151
BC	SER152
BC	CYS153
BC	CYS183
BC	PRO184
BQ	HIS223

site_id	AJ7
Number of Residues	9
Details	binding site for residue 8Q1 BE 201

Chain	Residue
BE	MET25
BE	TRP39
BE	MET66
BE	PHE67
BE	ASN70
BE	VAL79
BE	LEU82
BE	VAL83
BG	SER112

site_id	AJ8
Number of Residues	18
Details	binding site for residue NDP BJ 401

Chain	Residue
BJ	GLY60
BJ	THR62
BJ	GLY63
BJ	PHE64
BJ	LEU65
BJ	ALA110
BJ	LEU129
BJ	ILE130
BJ	GLY131
BJ	ARG132
BJ	PHE145
BJ	SER168
BJ	HIS169
BJ	TYR180
BJ	LYS184
BJ	PRO203
BJ	ILE206
BJ	ARG212

site_id	AJ9
Number of Residues	9
Details	binding site for residue SF4 BM 801

Chain	Residue
BM	HIS124
BM	ASP127
BM	CYS128
BM	CYS131
BM	GLY134
BM	CYS137
BM	GLN140
BM	VAL228
BM	GLY229

site_id	AK1
Number of Residues	9
Details	binding site for residue FES BM 803

Chain	Residue
BM	ARG62
BM	CYS64
BM	TYR65
BM	ALA72
BM	ASN74
BM	CYS75
BM	MET77
BM	CYS78
BM	CYS92

site_id	AK2
Number of Residues	9
Details	binding site for residue FES BO 301

Chain	Residue
BO	CYS135
BO	THR137
BO	PRO139
BO	CYS140
BO	CYS176
BO	LEU177
BO	GLY178
BO	ALA179
BO	CYS180

site_id	AK3
Number of Residues	8
Details	binding site for residue PLX BU 101

Chain	Residue
BU	ALA12
BU	GLU16
BU	PHE23
BU	GLY26
Bj	TRP106
Bj	LEU107
Bj	ASP112
Bs	PRO295

site_id	AK4
Number of Residues	11
Details	binding site for residue CDL BV 201

Chain	Residue
BV	THR35
BV	TYR39
BV	ARG40
BV	ASN44
BV	TYR59
BV	THR62
Bi	PRO110
Bi	HIS112
Bi	LEU160
Bl	ILE576
Bl	THR577

site_id	AK5
Number of Residues	5
Details	binding site for residue PEE BV 202

Chain	Residue
BV	TRP133
Bi	LEU276
Bi	ILE277
Bi	THR284
Bl	PEE701

site_id	AK6
Number of Residues	7
Details	binding site for residue PLX BV 203

Chain	Residue
BV	TYR108
BV	GLY109
BV	ALA112
Bl	LEU553
Bo	PRO82
Bo	ALA91
Bo	PHE95

site_id	AK7
Number of Residues	12
Details	binding site for residue PEE BW 201

Chain	Residue
BS	HIS40
BW	PHE140
BW	MET141
BW	TYR143
BW	THR144
Bj	LEU7
Bm	VAL37
Bm	LEU44
Bm	PHE56
Bs	LEU77
Bs	LEU98
Bs	PHE104

site_id	AK8
Number of Residues	9
Details	binding site for residue PLX Bb 201

Chain	Residue
Ba	THR87
Ba	ASN90
Ba	GLN95
Bb	TYR84
Bb	TYR88
Bb	GLU92
Bd	ARG43
Be	TYR108
Br	PLX502

site_id	AK9
Number of Residues	10
Details	binding site for residue PLX Bg 201

Chain	Residue
Bg	PRO9
Bg	LEU10
Bg	PHE12
Bg	ARG77
Bh	PRO2
Bh	PHE3
Bi	THR132
Bi	TRP133
Bi	TYR143
Bi	ILE346

site_id	AL1
Number of Residues	4
Details	binding site for residue PLX Bg 202

Chain	Residue
Bf	HIS62
Bg	LEU25
Bg	PHE35
Bg	PHE68

site_id	AL2
Number of Residues	10
Details	binding site for residue PLX Bg 203

Chain	Residue
Bf	LYS43
Bf	THR47
Bg	ARG48
Bg	ARG50
Bg	ARG59
Bg	LEU62
Bg	TYR63
Bg	PHE67
Bi	PRO324
Bi	PHE325

site_id	AL3
Number of Residues	9
Details	binding site for residue CDL Bi 401

Chain	Residue
Bg	LEU46
Bi	THR238
Bi	TRP239
Bi	THR241
Bi	PRO242
Bi	LEU243
Br	TRP16
Br	SER90
Br	LYS93

site_id	AL4
Number of Residues	11
Details	binding site for residue PEE Bl 701

Chain	Residue
BQ	GLN46
BQ	TYR53
BV	PEE202
Bi	ILE285
Bi	LEU288
Bi	TYR291
Bi	ARG295
Bl	SER567
Bl	GLN570
Bl	ILE571
Br	VAL155

site_id	AL5
Number of Residues	11
Details	binding site for residue PEE Bl 702

Chain	Residue
Bc	ARG116
Bl	THR166
Bl	GLN170
Bl	LEU173
Bl	TYR174
Bl	MET533
Bl	HIS534
Bl	ILE537
Bl	PRO538
Bl	GLY541
Bl	THR544

site_id	AL6
Number of Residues	13
Details	binding site for residue CDL Bl 703

Chain	Residue
Ba	LEU68
Ba	LEU71
Ba	ARG72
Bl	THR22
Bl	LEU23
Bl	PRO26
Bl	LYS28
Bl	GLN116
Bl	LYS119
Bl	TYR120
Br	LEU354
Br	PHE357
Br	LEU360

site_id	AL7
Number of Residues	6
Details	binding site for residue CDL Bl 704

Chain	Residue
Bc	ASP148
Bl	SER209
Bl	THR211
Bl	LEU214
Bl	LEU272
Br	ASN390

site_id	AL8
Number of Residues	11
Details	binding site for residue CDL Bn 101

Chain	Residue
Bg	THR26
Bg	LEU31
Bg	TYR32
Bi	PRO338
Bn	TYR26
Bn	LYS30
Bn	ARG34
Br	THR55
Br	PHE121
Bu	PHE169
Bu	TRP170

site_id	AL9
Number of Residues	15
Details	binding site for residue 8Q1 Bp 201

Chain	Residue
BX	ASP111
BX	SER112
BX	LEU113
Bp	GLN13
Bp	ALA23
Bp	HIS26
Bp	LEU27
Bp	MET44
Bp	ARG47
Bp	PHE48
Bp	HIS51
Bp	LYS52
Bp	GLU54
Bp	ALA60
Bp	ARG74

site_id	AM1
Number of Residues	7
Details	binding site for residue PLX Br 501

Chain	Residue
Bo	TYR102
Br	ASN188
Br	TRP190
Br	ASN193
Br	HIS256
Br	MET257
Br	PRO260

site_id	AM2
Number of Residues	8
Details	binding site for residue PLX Br 502

Chain	Residue
Bb	PLX201
Be	ALA107
Be	TYR108
Bl	ILE16
Br	LEU68
Br	TRP71
Br	LEU447
Br	ASN450

site_id	AM3
Number of Residues	3
Details	binding site for residue CU Bx 601

Chain	Residue
Bx	HIS240
Bx	HIS290
Bx	HIS291

site_id	AM4
Number of Residues	3
Details	binding site for residue MG Bx 602

Chain	Residue
Bx	HIS368
Bx	ASP369
By	GLU198

site_id	AM5
Number of Residues	23
Details	binding site for residue HEA Bx 603

Chain	Residue
Bx	GLY27
Bx	MET28
Bx	SER34
Bx	ILE37
Bx	ARG38
Bx	TYR54
Bx	VAL58
Bx	HIS61
Bx	ALA62
Bx	MET65
Bx	ILE66
Bx	VAL70
Bx	GLY125
Bx	TRP126
Bx	TYR371
Bx	PHE377
Bx	HIS378
Bx	SER382
Bx	PHE425
Bx	GLN428
Bx	ARG438
Bx	ARG439
Bx	MET468

site_id	AM6
Number of Residues	22
Details	binding site for residue HEA Bx 604

Chain	Residue
Bx	TRP126
Bx	TRP236
Bx	VAL243
Bx	TYR244
Bx	HIS290
Bx	HIS291
Bx	THR309
Bx	ALA313
Bx	THR316
Bx	GLY317
Bx	GLY352
Bx	LEU353
Bx	GLY355
Bx	ILE356
Bx	LEU358
Bx	ALA359
Bx	ASP364
Bx	HIS368
Bx	HIS376
Bx	PHE377
Bx	VAL380
Bx	ARG438

site_id	AM7
Number of Residues	5
Details	binding site for residue CU By 301

Chain	Residue
By	HIS161
By	CYS196
By	CYS200
By	MET207
By	CU302

site_id	AM8
Number of Residues	5
Details	binding site for residue CU By 302

Chain	Residue
By	CYS196
By	GLU198
By	CYS200
By	HIS204
By	CU301

site_id	AM9
Number of Residues	4
Details	binding site for residue ZN B2 101

Chain	Residue
B2	CYS60
B2	CYS62
B2	CYS82
B2	CYS85

site_id	AN1
Number of Residues	11
Details	binding site for Di-peptide SF4 BM 802 and CYS BM 176

Chain	Residue
BM	THR174
BM	ARG175
BM	ILE177
BM	GLN178
BM	CYS179
BM	CYS182
BM	CYS226
BM	PRO227
BM	VAL228
BM	ALA230
BM	LEU231

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
G	ASP107-MET122

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
G	ASP132-ILE144

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
x	TRP236-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
y	VAL159-MET207

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedfsnlGtTHLLRLTsSlTT

Chain	Residue	Details
AW	GLY68-THR91

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
B	CYS111-PRO122
B	CYS150-PRO161

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
Q	LEU116-LYS127

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
P	GLU167-LEU188

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
M	PRO61-CYS78

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
M	CYS128-GLN140

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
M	ARG175-PHE185

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
A	GLY200-SER215

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
A	GLU377-GLY388

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpFaDAMKLFtKE

Chain	Residue	Details
s	GLY44-GLU59

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEGEseLVs.G

Chain	Residue	Details
s	PRO197-GLY210

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
B2	VAL69-LEU91

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
O	ASP166-PRO184

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYiPgCPP

Chain	Residue	Details
C	GLY169-PRO185

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
B3	ILE55-ASN72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	442
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
r	MET22-PHE42
r	LEU351-PRO371
r	ILE391-PHE411
Br	MET22-PHE42
Br	PRO60-SER80
Br	LEU102-PHE122
Br	ALA145-ILE165
Br	TRP196-LEU216
Br	PRO224-MET244
Br	MET257-LEU277
Br	SER284-ILE303
r	PRO60-SER80
Br	SER308-ALA330
Br	LEU351-PRO371
Br	ILE391-PHE411
Bl	LEU272-ALA292
Bl	ILE301-ASN320
Bl	ALA325-ILE347
Bl	SER370-TYR390
Bl	TRP407-LEU429
Bl	ALA458-PHE478
Bl	ILE482-LEU502
r	LEU102-PHE122
Bl	GLY582-ILE602
r	ALA145-ILE165
r	TRP196-LEU216
r	PRO224-MET244
r	MET257-LEU277
r	SER284-ILE303
r	SER308-ALA330

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9CZ13

Chain	Residue	Details
AL	LYS138
AL	LYS248
AY	LYS138
AY	LYS248
AV	HIS83
AV	HIS97
AV	HIS182
AV	HIS196

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9CZ13

Chain	Residue	Details
AL	LYS163
AY	LYS163
B0	LYS7
B0	LYS38
Bz	PHE35-MET40
Bz	LEU106-GLU128
Bz	ALA184-ASP190
Bz	TYR257-SER261

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q68FY0

Chain	Residue	Details
AL	SER212
AP	SER241
AY	SER212
AU	CYS121
AU	CYS124
AC	SER241
AP	CYS217
AP	HIS219
AP	CYS236
AP	HIS239

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:28844695, ECO:0007744\|PDB:5XTE, ECO:0007744\|PDB:5XTH

Chain	Residue	Details
AH	HIS125
By	CYS200
By	HIS204
By	MET207
AU	HIS125
B0	SER34
B0	SER36
y	HIS204
y	MET207
By	HIS161
By	CYS196
By	GLU198

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:28844695, ECO:0007744\|PDB:5XTH

Chain	Residue	Details
AH	MET244
AU	MET244
x	VAL287-ASP298
Bx	VAL118-GLY140
Bx	ARG213-ASP227
Bx	VAL287-ASP298

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
AH	SER182
AU	SER182

site_id	SWS_FT_FI8
Number of Residues	64
Details	TRANSMEM: Helical; Name=VI => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
z	GLY191-LEU223
Bz	GLY191-LEU223

site_id	SWS_FT_FI9
Number of Residues	46
Details	TRANSMEM: Helical; Name=VII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
z	PHE233-ILE256
Bz	PHE233-ILE256

site_id	SWS_FT_FI10
Number of Residues	32
Details	TRANSMEM: Helical; Name=VII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	TYR270-ILE286
Bx	TYR270-ILE286

site_id	SWS_FT_FI11
Number of Residues	56
Details	TRANSMEM: Helical; Name=VIII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	VAL299-LEU327
Bx	VAL299-LEU327

site_id	SWS_FT_FI12
Number of Residues	14
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	HIS328-SER335
Bx	HIS328-SER335

site_id	SWS_FT_FI13
Number of Residues	42
Details	TRANSMEM: Helical; Name=IX => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	PRO336-VAL357
Bx	PRO336-VAL357

site_id	SWS_FT_FI14
Number of Residues	48
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	LEU358-THR370
x	SER434-ALA446
Bx	LEU358-THR370
Bx	SER434-ALA446

site_id	SWS_FT_FI15
Number of Residues	58
Details	TRANSMEM: Helical; Name=X => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	TYR371-PHE400
Bx	TYR371-PHE400

site_id	SWS_FT_FI16
Number of Residues	52
Details	TRANSMEM: Helical; Name=XI => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	ASP407-LEU433
Bx	ASP407-LEU433

site_id	SWS_FT_FI17
Number of Residues	62
Details	TRANSMEM: Helical; Name=XII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
x	TYR447-SER478
Bx	TYR447-SER478

site_id	SWS_FT_FI18
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:27605664, ECO:0000305\|PubMed:23537388

Chain	Residue	Details
x	GLU40
x	GLY45
x	SER441
Bx	GLU40
Bx	GLY45
Bx	SER441

site_id	SWS_FT_FI19
Number of Residues	6
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:20385840, ECO:0000269\|PubMed:8638158

Chain	Residue	Details
x	HIS61
x	HIS376
x	HIS378
Bx	HIS61
Bx	HIS376
Bx	HIS378

site_id	SWS_FT_FI20
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:20385840, ECO:0000269\|PubMed:8638158

Chain	Residue	Details
x	HIS240
Bx	ASP369
x	HIS290
x	HIS291
x	HIS368
x	ASP369
Bx	HIS240
Bx	HIS290
Bx	HIS291
Bx	HIS368

site_id	SWS_FT_FI21
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
x	TYR244
Bx	TYR244

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:2165784

Chain	Residue	Details
x	MET1
Bx	MET1

site_id	SWS_FT_FI23
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269\|PubMed:10338009

Chain	Residue	Details
x	HIS240
x	TYR244
Bx	HIS240
Bx	TYR244

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
x	HIS61	metal ligand
x	HIS290	metal ligand
x	HIS291	metal ligand, proton acceptor, proton donor
x	THR316	proton acceptor, proton donor, proton relay
x	LYS319	proton acceptor, proton donor, proton relay
x	ARG438	proton acceptor, proton donor, proton relay
x	ASP91	proton acceptor, proton donor, proton relay
x	TRP126	proton acceptor, proton donor, proton relay
x	SER156	proton acceptor, proton donor, proton relay
x	SER157	proton acceptor, proton donor, proton relay
x	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
x	GLU242	proton acceptor, proton donor, proton relay
x	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
x	SER255	proton acceptor, proton donor, proton relay

site_id	MCSA2
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
Bx	HIS61	metal ligand
Bx	HIS290	metal ligand
Bx	HIS291	metal ligand, proton acceptor, proton donor
Bx	THR316	proton acceptor, proton donor, proton relay
Bx	LYS319	proton acceptor, proton donor, proton relay
Bx	ARG438	proton acceptor, proton donor, proton relay
Bx	ASP91	proton acceptor, proton donor, proton relay
Bx	TRP126	proton acceptor, proton donor, proton relay
Bx	SER156	proton acceptor, proton donor, proton relay
Bx	SER157	proton acceptor, proton donor, proton relay
Bx	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
Bx	GLU242	proton acceptor, proton donor, proton relay
Bx	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
Bx	SER255	proton acceptor, proton donor, proton relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)