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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XSY

Structure of the Nav1.4-beta1 complex from electric eel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
B	0001518	cellular_component	voltage-gated sodium channel complex
B	0006814	biological_process	sodium ion transport
B	0017080	molecular_function	sodium channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	876
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-ARG117
A	ASP1265-THR1320
A	ARG1377-PHE1380
A	ARG1438-ASN1453
A	GLU1568-VAL1820
A	PHE172-HIS176
A	PRO225-ASP243
A	MET403-LYS557
A	ASP621-TYR625
A	PRO672-ASN690
A	SER791-THR1004
A	LYS1059-ALA1065
A	GLU1113-ASN1131

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat I

Chain	Residue	Details
A	VAL118-PHE138

site_id	SWS_FT_FI3
Number of Residues	313
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	MET139-LYS149
A	GLY1087-LEU1091
A	GLY1153-ALA1199
A	ALA1222-TYR1243
A	GLU1342-ASP1352
A	GLY1399-PHE1416
A	TYR1475-THR1490
A	THR1514-GLY1543
A	THR198-LEU203
A	GLY265-ASN346
A	ARG372-TYR378
A	ASN579-SER599
A	GLU644-MET650
A	LYS712-ASP734
A	ASP756-CYS766
A	ARG1026-ALA1037

site_id	SWS_FT_FI4
Number of Residues	21
Details	TRANSMEM: Helical; Name=S2 of repeat I

Chain	Residue	Details
A	ILE150-GLY171

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=S3 of repeat I

Chain	Residue	Details
A	PHE177-ILE197

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat I

Chain	Residue	Details
A	ARG204-PHE224

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat I

Chain	Residue	Details
A	VAL244-MET264

site_id	SWS_FT_FI8
Number of Residues	87
Details	INTRAMEM: Pore-forming => ECO:0000250\|UniProtKB:D0E0C2

Chain	Residue	Details
A	PHE347-LEU371
A	PHE735-TRP755
A	GLY1200-ALA1221
A	PHE1491-PRO1513

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=S6 of repeat I

Chain	Residue	Details
A	MET379-ALA402

site_id	SWS_FT_FI10
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat II

Chain	Residue	Details
A	TRP558-LEU578

site_id	SWS_FT_FI11
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat II

Chain	Residue	Details
A	ALA600-LEU620

site_id	SWS_FT_FI12
Number of Residues	17
Details	TRANSMEM: Helical; Name=S3 of repeat II

Chain	Residue	Details
A	PHE626-LEU643

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat II

Chain	Residue	Details
A	GLN651-TRP671

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat II

Chain	Residue	Details
A	LEU691-GLY711

site_id	SWS_FT_FI15
Number of Residues	23
Details	TRANSMEM: Helical; Name=S6 of repeat II

Chain	Residue	Details
A	LEU767-LEU790

site_id	SWS_FT_FI16
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat III

Chain	Residue	Details
A	PHE1005-TRP1025

site_id	SWS_FT_FI17
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat III

Chain	Residue	Details
A	ASP1038-PHE1058

site_id	SWS_FT_FI18
Number of Residues	20
Details	TRANSMEM: Helical; Name=S3 of repeat III

Chain	Residue	Details
A	TRP1066-LEU1086

site_id	SWS_FT_FI19
Number of Residues	20
Details	TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat III

Chain	Residue	Details
A	GLY1092-PHE1112

site_id	SWS_FT_FI20
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat III

Chain	Residue	Details
A	VAL1132-ALA1152

site_id	SWS_FT_FI21
Number of Residues	20
Details	TRANSMEM: Helical; Name=S6 of repeat III

Chain	Residue	Details
A	PHE1244-ILE1264

site_id	SWS_FT_FI22
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat IV

Chain	Residue	Details
A	GLN1321-VAL1341

site_id	SWS_FT_FI23
Number of Residues	23
Details	TRANSMEM: Helical; Name=S2 of repeat IV

Chain	Residue	Details
A	ILE1353-LEU1376

site_id	SWS_FT_FI24
Number of Residues	17
Details	TRANSMEM: Helical; Name=S3 of repeat IV

Chain	Residue	Details
A	PHE1381-ILE1398

site_id	SWS_FT_FI25
Number of Residues	20
Details	TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat IV

Chain	Residue	Details
A	ARG1417-ILE1437

site_id	SWS_FT_FI26
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat IV

Chain	Residue	Details
A	ILE1454-ALA1474

site_id	SWS_FT_FI27
Number of Residues	23
Details	TRANSMEM: Helical; Name=S6 of repeat IV

Chain	Residue	Details
A	ILE1544-LEU1567

site_id	SWS_FT_FI28
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN278
A	ASN288
A	ASN317
A	ASN591
A	ASN1160
A	ASN1174

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PDB entries from 2024-07-10

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